Results 101 to 110 of about 125,005 (308)

Role of MicroRNA in linking diabetic retinal neurodegeneration and vascular degeneration

Frontiers in Endocrinology
Diabetic retinopathy is the major cause of blindness in diabetic patients, with limited treatment options that do not always restore optimal vision. Retinal nerve degeneration and vascular degeneration are two primary pathological processes of diabetic ...
Haiyan Zhao, Yichen Cai, Junhua Pan, Qiu Chen   +3 more
doaj   +1 more source

Progression of transsynaptic retinal degeneration with spectral-domain optical coherence tomography

American Journal of Ophthalmology Case Reports, 2017
Purpose: To illustrate the progression of retrograde transsynaptic retinal degeneration using spectral-domain optical coherence tomography (SD-OCT). Observations: A 60 year-old man with a stroke was followed over a 17-month period using SD-OCT of the ...
Stephen G. Schwartz, Armando Monroig, Harry W. Flynn, Jr   +2 more
doaj   +1 more source

Gene Therapy for Retinal Degeneration [PDF]

Cell, 2018
Biallelic mutations in the RPE65 gene are associated with inherited retinal degenerations/dystrophies (IRD) and disrupt the visual cycle, leading to loss of vision. A new adenoviral vector-based gene therapy surgically delivered to retinal cells provides normal human RPE65 protein that can restore the visual cycle and some vision. To view this Bench to
openaire   +2 more sources

Overcrowded Alkene Photo‐Redox‐Switches Based on Quinolinium/Carbene Building Blocks

Angewandte Chemie International Edition, EarlyView.
A modular synthesis of a new class of photo‐ and redox‐switches is described based on the combination of quinolinium salts and carbenes. Photochemical switching allows to selectively switch between folded E/Z isomers, while electrochemical switching allows to change between neutral, radical cation and dicationic oxidation states, which are all isolable
Chris Burdenski, Patrick W. Antoni, Marcel E. Baumert, Leonie Ziemann, Samaresh C. Sau, Julian J. Holstein, Maria Castro, Nitin Kumar, Ofer Filiba, Igor Schapiro, Max M. Hansmann   +10 more
wiley   +1 more source

In vivo sectional imaging of the retinal periphery using conventional optical coherence tomography systems

Indian Journal of Ophthalmology, 2012
Optical coherence tomography (OCT) has transformed macular disease practices. This report describes the use of conventional OCT systems for peripheral retinal imaging.
Abhishek Kothari, V Narendran, V R Saravanan   +2 more
doaj   +1 more source

Prevalence of age-related macular degeneration in Nakuru, Kenya: a cross-sectional population-based study. [PDF]

, 2013
BACKGROUND: Diseases of the posterior segment of the eye, including age-related macular degeneration (AMD), have recently been recognised as the leading or second leading cause of blindness in several African countries.
Peto, Tunde; id_orcid, Bastawrous, Andrew, Andrew Bastawrous, Foster, Allen, Kuper Hannah, Allen Foster, Tunde Peto, Hannah Kuper, Tunde Peto (295260), Leung Irene, Irene Leung (336330), Leung, Irene, Wanjiku Mathenge (336328), Bastawrous Andrew, Andrew Bastawrous (336329), Peto Tunde, Hannah Kuper (25751), Wanjiku Mathenge, Allen Foster (94749), Peto, Tunde, Kuper, Hannah, Mathenge Wanjiku, Irene Leung, Mathenge, Wanjiku, Foster Allen   +24 more
core   +1 more source

Quantum Phenomena in Molecular and Biological Systems: A Decoherence‐Based Decision Framework With Falsifiable Predictions and a Failure‐Mode Taxonomy

Advanced Physics Research, EarlyView.
A physics‐grounded framework based on decoherence timescales (τ_dec vs τ_func), Markovian validity, and falsifiability criteria is applied across molecular systems to distinguish where quantum effects are necessary, marginal, or irrelevant. The analysis integrates quantum chemistry, biological quantum mechanisms, and quantum computing under a unified ...
Sarfaraz K. Niazi
wiley   +1 more source

Modulation and function of microglial phenotypes

, 2012
Microglia are the sentinel cells of the retina, where they are involved in surveillance of tissue integrity and clearance of cellular debris. The innate immune functions of microglia are tightly controlled by retinal neurons via the secretion of ...
Karlstetter, Marcus
core   +1 more source

Ceramide Signaling in Retinal Degeneration [PDF]

, 2011
Retinal degenerations (RD) are a complex heterogeneous group of diseases in which retinal photoreceptors and the supporting retinal pigment epithelial cells die irreversibly, causing visual loss for millions of people. Mutations on more than 150 genes have been discovered for RD and there are many forms that possess complex etiology involving more than
Hui, Chen, Julie-Thu A, Tran, Richard S, Brush, Anisse, Saadi, Abul K, Rahman, Man, Yu, Douglas, Yasumura, Michael T, Matthes, Kelly, Ahern, Haidong, Yang, Matthew M, LaVail, Md Nawajes A, Mandal   +11 more
openaire   +2 more sources

Cost–benefit analysis of screening programme for diabetic retinopathy in Bulgaria

British Journal of Clinical Pharmacology, EarlyView.
Aims Late‐diagnosed diabetic retinopathy (DR) is difficult and expensive to treat. Screening programmes can identify the disease early and reduce the costs of its future treatment. This study aims to analyse the cost–benefit of screening programmes for DR.
Iva Nenkova, Yoana Lilova, Alexander Oscar, Alina Levi, Maria Kamusheva, Guenka Petrova   +5 more
wiley   +1 more source