Results 121 to 130 of about 640,739 (357)

Abnormal mTORC1 signaling leads to retinal pigment epithelium degeneration

Theranostics, 2019
Retinal pigment epithelial (RPE) degeneration is potentially involved in the pathogenesis of several retinal degenerative diseases. mTORC1 signaling is shown as a crucial regulator of many biological processes and disease progression.
Jiancheng Huang, Shun Gu, Meng Chen, Shu-jie Zhang, Zhichun Jiang, Xue Chen, Chao Jiang, Guohua Liu, R. Radu, Xiantao Sun, D. Vollrath, Jianhai Du, B. Yan, Chen Zhao   +13 more
semanticscholar   +1 more source

Nanostructured drug delivery systems for posterior segment eye diseases: Strategies to defy ocular barriers

BMEMat, EarlyView.
Efficient drug delivery to the posterior segment of the eye has long been a challenging issue due to the complex ocular barriers. The review focuses on the promise held by nanoplatforms for barrier penetration and the key mechanisms involved, also highlighting their advantages in achieving efficient drug delivery and superior treatment of PSEDs ...
Yifan Shen, Ying Yao, Yan Zhang, Xinyu Shi, Ling Bai, Yang Zhong, Yan Zhang, Kun Zhang   +7 more
wiley   +1 more source

Two Brothers with Infantilism, Showing Some Features of Progeria, Associated with Microcephaly, Retinal Degeneration and Intracranial Calcification [PDF]

, 1948
Catherine A. Neill, M. M. Dingwall, Molly Mackay   +2 more
openalex   +1 more source

Photoreceptor Cells Influence Retinal Vascular Degeneration in Mouse Models of Retinal Degeneration and Diabetes

Investigative Ophthalmology and Visual Science, 2016
Purpose Loss of photoreceptor cells is associated with retinal vascular degeneration in retinitis pigmentosa, whereas the presence of photoreceptor cells is implicated in vascular degeneration in diabetic retinopathy.
Haitao Liu, Jie-long Tang, Yunpeng Du, A. Saadane, Deoye Tonade, I. Samuels, A. Veenstra, K. Palczewski, T. Kern   +8 more
semanticscholar   +1 more source

Energy Landscapes in Chemical Reactions and Transport

ChemPhysChem, Volume 26, Issue 6, March 15, 2025.
Kinetics/dynamics of chemical reactivity and transport of chemical species in a solid are both determined by the energy landscape in which they take place. Discussing common grounds but also distinct differences may help in advancing the understanding in both fields.
Karl‐Michael Weitzel
wiley   +1 more source

Cerebro-retinal degeneration due to carbon dioxide poisoning. [PDF]

, 1967
D Sevel, Arnold S. Freedman
openalex   +1 more source

ERYTHROCYTIC ANOMALIES IN HEREDITARY VITREO-RETINAL DEGENERATION (DEGENERATIO HYALOIDEORETINALIS) [PDF]

, 1963
A Kahán, I.L. Kahán, A Benkö, S. Mindszenti   +3 more
openalex   +1 more source

Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration

EMBO Molecular Medicine, 2015
Retinitis pigmentosa, caused predominantly by mutations in photoreceptor genes, currently lacks comprehensive treatment. We discover that retinal microglia contribute non‐cell autonomously to rod photoreceptor degeneration by primary phagocytosis of ...
Lian Zhao, M. Zabel, Xu Wang, Wenxin Ma, Parth Shah, R. Fariss, H. Qian, Christopher N. Parkhurst, W. Gan, W. Wong   +9 more
semanticscholar   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Syndrome of pigmentary retinal degeneration, cataract, microcephaly, and severe mental retardation. [PDF]

, 1972
Seyed Ali Mirhosseini, Lewis B. Holmes, David S. Walton   +2 more
openalex   +1 more source