Results 151 to 160 of about 640,739 (357)

Voluntary exercise preserves visual function and reduces inflammatory response in an adult mouse model of autosomal dominant retinitis pigmentosa

Scientific Reports
Whole-body physical exercise has been shown to promote retinal structure and function preservation in animal models of retinal degeneration. It is currently unknown how exercise modulates retinal inflammatory responses.
Katie L. Bales, Austin M. Karesh, Kelleigh Hogan, Alicia S. Chacko, GianMarco L. Douglas, Andrew J. Feola, John M. Nickerson, Alyssa Pybus, Levi Wood, Jeffrey H. Boatright, Machelle T. Pardue   +10 more
doaj   +1 more source

Establishment of Immunodeficient Retinal Degeneration Model Mice and Functional Maturation of Human ESC-Derived Retinal Sheets after Transplantation

Stem Cell Reports, 2018
Summary: Increasing demand for clinical retinal degeneration therapies featuring human ESC/iPSC-derived retinal tissue and cells warrants proof-of-concept studies.
Satoshi Iraha, Hung-Ya Tu, Suguru Yamasaki, Takahiro Kagawa, Motohito Goto, Riichi Takahashi, Takehito Watanabe, Sunao Sugita, Shigenobu Yonemura, Genshiro A. Sunagawa, Take Matsuyama, Momo Fujii, Atsushi Kuwahara, Akiyoshi Kishino, Naoshi Koide, Mototsugu Eiraku, Hidenobu Tanihara, Masayo Takahashi, Michiko Mandai   +18 more
doaj  

A frameshift mutation in prominin (mouse)-like 1 causes human retinal degeneration [PDF]

, 2000
Marion A. Maw, Denis Corbeil, Julian Koch, Andrea Hellwig, Jane C Wilson-Wheeler, Robert J. Bridges, Govindasamy Kumaramanickavel, Simon W. M. John, Derek J. Nancarrow, Katja Röper, Anja Weigmann, Wieland Β. Huttner, M. J. Denton   +12 more
openalex   +1 more source

Hereditary Spastic Paraplegia in Alberta: Lessons from a Well‐Defined Cohort Including the Indigenous Population

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Hereditary spastic paraplegias (HSP) are rare disorders sharing common features of leg spasticity with gait impairment. Simple and complex forms are recognized; over 50% of cases remain unsolved genetically. Little is known about the genetics of HSP among Indigenous Peoples. Objectives To describe clinical, radiological, and genetic
Ekhlas Assaedi, Setareh Ashtiani, Mehrdad A. Estiar, Ziv Gan‐Or, Erica D. McKenzie, Aakash Shetty, Guy Rouleau, Oksana Suchowersky   +7 more
wiley   +1 more source

Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments

Med Research, EarlyView.
ABSTRACT The immune microenvironment includes immune cells, cytokines, extracellular matrix, vesicles, etc. The interactions between these components form a unique local immune microecology. Although immunity serves as the defense against external pathogens, aberrant immune activation often contributes to disease development.
Guoqing Li, Yuxuan Wan, Alan Jiao, Ke Jiang, Gaoyuan Cui, Jinxin Tang, Simin Yu, Zhengang Hu, Songfeng Zhao, Zhenjie Yi, Lifu Long, Yang Yang, Xuehao Cui, Chunrun Qu   +13 more
wiley   +1 more source

Molecular ophthalmology: an update on animal models for retinal degenerations and dystrophies [PDF]

, 2000
Farhad Hafezi
openalex   +1 more source

Recent Advancements in the Treatment of Age‐Related Macular Degeneration

Med Research, EarlyView.
ABSTRACT Age‐related macular degeneration (AMD) is a prevalent cause of visual impairment and blindness among the elderly. AMD can be categorized into two subtypes: “wet” and “dry.” Current treatments for wet AMD mainly involve anti‐vascular endothelial growth factor (VEGF) drugs, and there are three U.S.
Shan Liu, Danyang Lv, Junran Sun, Huixun Jia, Fang Zheng, Felipe Pereira, Siddharth Narendran, Zhenyu Dong, Haiyun Liu, Shunxiang Gao, Peirong Huang   +10 more
wiley   +1 more source

Inherited retinal degeneration and apoptosis in mutant zebrafish [PDF]

, 2000
Frank J. Daly, Julie H. Sandell
openalex   +1 more source

Optic Disc Pallor in Parkinson's Disease: A UK Biobank Study

Movement Disorders, EarlyView.
Abstract Background Recent studies have suggested that retinal changes measured with optical coherence tomography are detectable in early Parkinson's disease (PD), highlighting the potential of ophthalmic biomarkers for diagnosis and monitoring. Objective We set out to investigate the relationship between optic disc pallor measured in fundoscopy images
Samuel Gibbon, David P. Breen, Thomas J. MacGillivray, UK Biobank Eye & Vision Consortium   +3 more
wiley   +1 more source

Selective degeneration of photoreceptors in retinal tissue in vitro: a new experimental model for retinitis pigmentosa [PDF]

, 2000
Rafael Linden, Fabíola G. de Freitas, Mona Lisa Leal‐Ferreira, Luciana B. Chiarini   +3 more
openalex   +1 more source