Results 31 to 40 of about 640,739 (357)

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV

Cell Communication and Signaling, 2019
Background The mechanistic target of rapamycin (mTOR) pathway is a potential target to inhibit pathologic processes in choroidal neovascularization. However, the exact role of mTOR signaling in the development of CNV remains obscure.
Jin Young Yang, Sanjar Batirovich Madrakhimov, Dong Hyuck Ahn, Hun Soo Chang, Sang Joon Jung, Seung Kwan Nah, Ha Yan Park, Tae Kwann Park   +7 more
doaj   +1 more source

Targeting molecular pathways for the treatment of inherited retinal degeneration

Neural Regeneration Research, 2020
Inherited retinal degeneration is a major cause of incurable blindness characterized by loss of retinal photoreceptor cells. Inherited retinal degeneration is characterized by high genetic and phenotypic heterogeneity with several genes mutated in ...
Meltem Kutluer, Li Huang, Valeria Marigo
doaj   +1 more source

The elusive scleral cartilages: Comparative anatomy and development in teleosts and avians

The Anatomical Record, EarlyView., 2023
Abstract The sclera of all vertebrate eyes is comprised of connective tissue, with some organisms developing cartilage within this tissue. A review of the cartilages that have been described in the vertebrate sclera and their anatomical relationships is discussed together with their potential homology.
Tamara A. Franz‐Odendaal
wiley   +1 more source

Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration

eLife, 2019
Age-related macular degeneration (AMD) is a progressive disease of the retinal pigment epithelium (RPE) and the retina leading to loss of central vision.
F. Storti, Katrin Klee, V. Todorova, Regula Steiner, A. Othman, S. D. van der Velde-Visser, M. Samardzija, I. Meneau, M. Barben, D. Karademir, Valda Pauzuolyte, S. Boye, Frank Blaser, C. Ullmer, J. Dunaief, T. Hornemann, L. Rohrer, A. D. den Hollander, A. von Eckardstein, J. Fingerle, C. Maugeais, C. Grimm   +21 more
semanticscholar   +1 more source

Combination of cGMP analogue and drug delivery system provides functional protection in hereditary retinal degeneration

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Development of treatments for hereditary degeneration of the retina (RD) is hampered by the vast genetic heterogeneity of this group of diseases and by the delivery of the drug to an organ protected by the blood–retina barrier.
E. Vighi, D. Trifunović, P. Veiga-Crespo, A. Rentsch, Dorit Hoffmann, A. Sahaboglu, T. Strasser, M. Kulkarni, E. Bertolotti, A. van den Heuvel, T. Peters, A. Reijerkerk, Thomas Euler, M. Ueffing, F. Schwede, H. Genieser, P. Gaillard, V. Marigo, P. Ekström, François Paquet-Durand   +19 more
semanticscholar   +1 more source

Gene Editing for <i>CEP290</i>-Associated Retinal Degeneration. [PDF]

N Engl J Med
BACKGROUND CEP290-associated inherited retinal degeneration causes severe early-onset vision loss due to pathogenic variants in CEP290. EDIT-101 is a clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9 ...
Pierce EA, Aleman TS, Jayasundera KT, Ashimatey BS, Kim K, Rashid A, Jaskolka MC, Myers RL, Lam BL, Bailey ST, Comander JI, Lauer AK, Maguire AM, Pennesi ME.   +13 more
europepmc   +2 more sources

Clinical and Molecular Characterization of PROM1-Related Retinal Degeneration

JAMA Network Open, 2019
Key Points Question What are the clinical and molecular characteristics of PROM1-related retinal degeneration? Findings In this case series of 19 patients with PROM1-related retinal degeneration, recessive variants were associated with early-onset ...
J. Cehajic-Kapetanovic, J. Birtel, M. McClements, M. Shanks, P. Clouston, S. Downes, P. Charbel Issa, R. MacLaren   +7 more
semanticscholar   +1 more source

Drosophila melanogaster White Mutant w1118 Undergo Retinal Degeneration

Frontiers in Neuroscience, 2018
Key scientific discoveries have resulted from genetic studies of Drosophila melanogaster, using a multitude of transgenic fly strains, the majority of which are constructed in a genetic background containing mutations in the white gene.
M. Ferreiro, Coralia Pérez, Mariana Marchesano, Santiago Ruiz, A. Caputi, P. Aguilera, R. Barrio, R. Cantera   +7 more
semanticscholar   +1 more source

A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica, Devin K. Binder, Meinrad Drexel, Chrysanthy Ikonomidou, Shilpa D. Kadam, Guenther Sperk, Christian Steinhäuser   +6 more
wiley   +1 more source

Inhibiting autophagy reduces retinal degeneration caused by protein misfolding

Autophagy, 2018
Mutations in the genes necessary for the structure and function of vertebrate photoreceptor cells are associated with multiple forms of inherited retinal degeneration.
Jingyu Yao, Yaoyan Qiu, Eric D. Frontera, Lin Jia, Naheed W. Khan, D. Klionsky, T. Ferguson, Debra Thompson, D. Zacks   +8 more
semanticscholar   +1 more source