Results 101 to 110 of about 9,860,660 (392)

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

The Performance of Spot Photoscreener in 6 to 10 Weeks Infants in China: A Cross-Sectional Study

Journal of Ophthalmology
Purpose. To compare the refractive errors measured by the Spot photoscreener (with or without cycloplegia) to cycloplegic retinoscopy in 6- to 10-week-old infants. Materials and Methods.
Yaoling Li, Jing Li, Huiyu Wang, Mingyang Du, Lirong Wei, Teng Su, Gang Ding, Xuehan Qian, Ning Hua   +8 more
doaj   +1 more source

Recent advances of exosomes in immune-mediated eye diseases

Stem Cell Research & Therapy, 2019
Exosomes, nanosized extracellular vesicles of 30–150 nm, are shed by almost all cell types. Bearing proteins, lipids, RNAs, and DNAs, exosomes have emerged as vital biological mediators in cell-to-cell communication, affecting a plethora of physiological
Na Li, Lu Zhao, Yankai Wei, Vicki L. Ea, Hong Nian, Ruihua Wei   +5 more
doaj   +1 more source

Idiopathic multifocal choroiditis (MFC): aggressive and prolonged therapy with multiple immunosuppressive agents is needed to halt the progression of active disease. An offbeat review and a case series

Journal of Ophthalmic Inflammation and Infection, 2022
Background and purpose Idiopathic multifocal choroiditis (MFC) is part of the group of choriocapillaritis entities. The clinical definition of the disease has evolved with time. The aim of this article was to undertake a review on MFC, on its present-day
Ioannis Papasavvas, Piergiorgio Neri, Alessandro Mantovani, Carl P. Herbort   +3 more
doaj   +1 more source

Metabolomics in Retinal Diseases: An Update

Biology, 2021
Simple Summary Visual loss and blindness caused by retinal disease has a significant negative effect on the quality of life of many adults and children, and as a result has become a global public health concern.
Xing Li, Shichang Cai, Zhiming He, J. Reilly, Zhihong Zeng, Niall C. Strang, X. Shu   +6 more
semanticscholar   +1 more source

Impact of obesity with impaired glucose tolerance on retinal degeneration in a rat model of metabolic syndrome. [PDF]

, 2017
PurposeMetabolic syndrome (MetS) is associated with several degenerative diseases, including retinal degeneration. Previously, we reported on progressive retinal degeneration in a spontaneous obese rat (WNIN/Ob) model.
Ayyagari, Radha, Godisela, Kishore Kumar, Jablonski, Monica M, Kumar, Chekkilla Uday, Reddy, Geereddy Bhanuprakash, Reddy, Paduru Yadagiri, Reddy, Singareddy Sreenivasa, Saravanan, Natarajan   +7 more
core  

Normative Data and Minimally Detectable Change for Inner Retinal Layer Thicknesses Using a Semi-automated OCT Image Segmentation Pipeline [PDF]

, 2019
Neurodegenerative and neuroinflammatory diseases regularly cause optic nerve and retinal damage. Evaluating retinal changes using optical coherence tomography (OCT) in diseases like multiple sclerosis has thus become increasingly relevant.
Asseyer, Susanna, Ayadi, Noah, Bereuter, Charlotte, Brandt, Alexander Ulrich, Gawlik, Kay, Kadas, Ella Maria, Mikolajczak, Janine, Motamedi, Seyedamirhosein, Paul, Friedemann, Zimmermann, Hanna G.   +9 more
core   +2 more sources

Retinoids and Retinal Diseases [PDF]

Annual Review of Vision Science, 2016
Recent progress in molecular understanding of the retinoid cycle in mammalian retina stems from painstaking biochemical reconstitution studies supported by natural or engineered animal models with known genetic lesions and studies of humans with specific genetic blinding diseases.
Kiser, Philip, Palczewski, Krzysztof
openaire   +4 more sources

Frontiers in diabetic retinal disease

Journal of Diabetes and its Complications, 2023
Diabetic retinal disease (DRD) remains a leading cause of vision loss and blindness globally. Although treatments can be effective when given at vision-threatening stages of DRD, there is a lack of knowledge about the earliest mechanisms leading to the development of clinically evident DRD.
Wistrup Torm, Marie E., Dorweiler, Tim F., Fickweiler, Ward, Levine, S. Robert, Fort, Patrice E., Sun, Jennifer K., Gardner, Thomas W.   +6 more
openaire   +2 more sources

Lessons Learned: Quality Analysis of Optical Coherence Tomography in Neuromyelitis Optica

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Optical coherence tomography (OCT)‐derived retina measurements are markers for neuroaxonal visual pathway status. High‐quality OCT scans are essential for reliable measurements, but their acquisition is particularly challenging in eyes with severe visual impairment, as often observed in neuromyelitis optica spectrum disorders ...
Hadi Salih, Sara Samadzadeh, Charlotte Bereuter, Seyedamirhosein Motamedi, Claudia Chien, Pablo Villoslada, Hadas Stiebel‐Kalish, Nasrin Asgari, Yang Mao‐Draayer, Marius Ringelstein, Joachim Havla, Marco Aurélio Lana Peixoto, Ho Jin Kim, Jacqueline Palace, Maria Isabel Leite, Srilakshmi M. Sharma, Fereshteh Ashtari, Rahele Kafieh, Lekha Pandit, Orhan Aktas, Philipp Albrecht, Letizia Leocani, Itay Lotan, Sasitorn Siritho, Jérôme de Seze, Romain Marignier, Caroline Froment Tilikete, Denis Bernardi Bichuetti, Ivan Maynart Tavares, Ayse Altintas, Anu Jacob, Saif Huda, Ibis Soto de Castillo, Lawrence J. Cook, Michael R. Yeaman, Axel Petzold, Alexander U. Brandt, Friedemann Paul, Frederike C. Oertel, Hanna G. Zimmermann, with the Guthy Jackson Charitable Foundation—International Clinical Consortium and CROCTINO Collaborators   +40 more
wiley   +1 more source