Results 81 to 90 of about 211,361 (268)

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

Advanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa   +9 more
wiley   +1 more source

The Role of Widefield Optical Coherence Tomography Angiography in Assessing the Severity of Diabetic Retinopathy

Ophthalmology and Therapy
Introduction Physicians need an accurate understanding of diabetic retinopathy (DR) severity to optimally manage patients. The aim of this prospective study is to correlate the severity of macular and peripheral retinal vascular abnormalities seen on ...
Deepika C. Parameswarappa, Amelia Janis Langstang, Sanagavarapu Kavya, Ashik Mohamed, Michael W. Stewart, Padmaja Kumari Rani   +5 more
doaj   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

Perfluorodecalin and Viscoelastic-Assisted Internal Limiting Membrane Flap Technique for High Myopia Macular Hole Retinal Detachment

Clinical Ophthalmology
Junwen He,1 Li Yan,1 Shan Wang2 1Department of Retinal & Vitreous Diseases, Aier Eye Hospital of Wuhan University, Wuhan, People’s Republic of China; 2Department of Ophthalmic Imaging, Aier Eye Hospital of Wuhan University, Wuhan, People’s Republic ...
He J, Yan L, Wang S
doaj  

Risk Factors for Focal Choroidal Excavation Concurrent with Chorioretinal Disease: Evaluated by Spectral-Domain OCT

Ophthalmology Science
Purpose: To investigate the risk factors for patients with focal choroidal excavation (FCE) and their correlation with chorioretinal diseases. Design: Retrospective cross-sectional study.
Yiwen Ou, MD, Minghui Qiu, MD, Mengyuan Li, MD, Yajun Mi, BS, Dezheng Wu, MD, PhD, Shibo Tang, MD, PhD, Weiwei Dai, MD, PhD, Jacey Hongjie Ma, MD, PhD   +7 more
doaj   +1 more source

The critical role of m6A methylation in the pathogenesis of Graves' ophthalmopathy

Eye and Vision, 2020
Purpose To investigate the role of N6-methyladenosine (m6A) RNA modification in the pathogenesis of Graves' ophthalmopathy (GO). Methods Surgically excised extraocular muscles from 7 patients with GO and 5 subjects without GO were used.
Li Zhu, Siyan Li, Shikun He, Qizhe Tong, Lejin Wang, Xiaohua Li, Xi Wu, Qingyu Meng, Enzhong Jin, Chuan Zhang, Tianyuan Li, Ningda Xu, Lvzhen Huang, Yi Wang, Mingwei Zhao   +14 more
doaj   +1 more source

Reversible thermosensitive glue for retinal implants [PDF]

, 2007
WOS: 000249612600020PubMed: 17891020Purpose: To determine in vitro effects of a plasma polymerized N-isopropyl acrylamide (pNIPAM) coating for thermally controllable adhesion to retinal tissue.
Cheng, Xuanhong, Humayun, Mark, Ratner, Buddy D., Meng, Ellis, Tunç, Murat   +4 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Unmasking of molecular players: proteomic profiling of vitreous humor in pathologic myopia

BMC Ophthalmology
Background This study aimed to identify the differentially expressed proteins in the vitreous humor (VH) of eyes with and without pathologic myopia (PM), providing insights into the molecular pathogenesis.
Yue Wen, Chi Ren, Li Zhu, Lvzhen Huang, Huijun Qi, Wenzhen Yu, Kai Wang, Mingwei Zhao, Qiong Xu   +8 more
doaj   +1 more source

Retina and glaucoma: surgical complications

International Journal of Retina and Vitreous, 2018
Background The close structural and microcirculatory co-relation between anterior and posterior segments of eye make them very vulnerable to complications when one of them is affected surgically.
Niroj Kumar Sahoo, Pasyanthi Balijepalli, Sumit Randhir Singh, Mahima Jhingan, Sirisha Senthil, Jay Chhablani   +5 more
doaj   +1 more source