Results 51 to 60 of about 205,905 (259)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

TOXICITY and RETINAL PENETRATION of INFLIXIMAB in PRIMATES [PDF]

, 2012
Purpose: To evaluate the retinal penetration and toxicity of two doses of intravitreal infliximab in primates.Methods: Ten marmosets (Callithrix jacchus) were given intravitreal injection of 100 mu g or 400 mu g of infliximab, and balanced salt solution ...
Coimbra, Rita C. S. G. [UNIFESP], Haapalainen, Edna Freymuller [UNIFESP], Eduardo B Rodrigues, Marcelo M Pinheiro, Milton N Moraes Filho, Gustavo B Melo, Juliana L Dreyfuss, Regatieri, Caio V. [UNIFESP], Moraes Filho, Milton N. [UNIFESP], Rodrigues, Eduardo B. [UNIFESP], Edna F Haapalainen, Pinheiro, Marcelo M. [UNIFESP], Michel E Farah, Farah, Michel E. [UNIFESP], Rita C S G Coimbra, Caio V Regatieri, Dreyfuss, Juliana L. [UNIFESP], Penha, Fernando M. [UNIFESP], Fernando M Penha, Melo, Gustavo B. [UNIFESP]   +19 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Retinal imaging / [PDF]

, 2006
Internationally recognized experts in retina, glaucoma, and imaging techniques provide a complete review of posterior segment imaging. It is brief enough to read as a primer on ophthalmic imaging, yet comprehensive enough to refer to when you encounter ...
Huang, David.
core  

Artificial intelligence and deep learning in retinal image analysis [PDF]

, 2019
Publisher Copyright: © 2019 Elsevier Ltd. All rights reserved.Our goal in this chapter is to describe the recent application of deep learning and artificial intelligence (AI) techniques to retinal image analysis.
Burlina, Philippe, Cohen, Adam, Galdran, Adrian, Costa, Pedro, Campilho, Aurélio   +4 more
core   +1 more source

Amyloidosis in Retinal Neurodegenerative Diseases [PDF]

Frontiers in Neurology, 2016
As a part of the central nervous system, the retina may reflect both physiological processes and abnormalities related to pathologies that affect the brain. Amyloidosis due to the accumulation of amyloid-beta (Aβ) was initially regarded as a specific and exclusive characteristic of neurodegenerative alterations seen in the brain of Alzheimer's disease (
Masuzzo, Ambra, Dinet, Virginie, Cavanagh, Chelsea, Mascarelli, Frederic, Krantic, Slavica   +4 more
openaire   +3 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Gene Therapy for Retinal Disease [PDF]

Translational Research, 2013
Gene therapy strategies for the treatment of inherited retinal diseases have made major advances in recent years. This review focuses on adeno-associated viral (AAV) vector approaches to treat retinal degeneration and, thus, prevent or delay the onset of blindness.
McClements, M, MacLaren, R
openaire   +2 more sources

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source