Results 111 to 120 of about 68,022 (253)

Neuroprotective effects of VCP modulators in mouse models of glaucoma

Heliyon, 2016
Glaucoma is a major cause of adult blindness due to gradual death of retinal ganglion cells. Currently, no therapeutics are available for the protection of these cells from the cell death. We have recently succeeded in synthesizing novel compounds, KUSs (
Noriko Nakano, Hanako Ohashi Ikeda, Tomoko Hasegawa, Yuki Muraoka, Sachiko Iwai, Tatsuaki Tsuruyama, Masaki Nakano, Tomohiro Fuchigami, Toshiyuki Shudo, Akira Kakizuka, Nagahisa Yoshimura   +10 more
doaj   +1 more source

Structural Change Can Be Detected in Advanced-Glaucoma Eyes. [PDF]

, 2016
PurposeTo compare spectral-domain optical coherence tomography (SD-OCT) standard structural measures and a new three-dimensional (3D) volume optic nerve head (ONH) change detection method for detecting change over time in severely advanced-glaucoma (open-
Belghith, Akram, Bowd, Christopher, Girkin, Christopher A, Liebmann, Jeffrey M, Medeiros, Felipe A, Weinreb, Robert N, Zangwill, Linda M   +6 more
core   +2 more sources

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source

The Effects of Neurosteroids, such as Pregnenolone Sulfate and its receptor, TrpM3 in the Retina. [PDF]

, 2019
Pregnenolone sulfate (PregS) is the precursor to all steroid hormones and is produced in neurons in an activity dependent manner. Studies have shown that PregS production is upregulated during certain critical periods of development, such as in the first
Webster, Corey Michael
core  

Mosaic activation of the zebrafish hsp70l heat shock promoter: Implications for interpreting transgenes

Developmental Dynamics, EarlyView.
Abstract Background The promoters and enhancers of heat shock genes, such as the 1.5‐kb promoter of the zebrafish hsp70l gene, are valuable tools for temporal activation of transgenes. It has been widely purported that heat shock treatments result in ubiquitous expression of hsp70l‐driven transgenes.
Jong‐Su Park, Xiangyun Wei
wiley   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Macular structural integrity estimates are associated with Parkinson’s disease genetic risk

Acta Neuropathologica Communications
Background Optical coherence tomography (OCT) is a non-invasive technique to measure retinal layer thickness, providing insights into retinal ganglion cell integrity.
Santiago Diaz-Torres, Samantha Sze-Yee Lee, Natalia S. Ogonowski, David A. Mackey, Stuart MacGregor, Puya Gharahkhani, Miguel E. Renteria   +6 more
doaj   +1 more source

Age effect on retina and optic disc normal values [PDF]

, 2005
Purpose: To investigate retinal thickness and optic disc parameters by the Retinal Thickness Analyzer (RTA) glaucoma program in older normal subjects and to determine any age effect.
Aljoscha S. Neubauer, Anselm Kampik, Azuara-Blanco A, Bozkurt B, Christoph Hirneiss, Christos Chryssafis, Emi K, Garway-Heath DF, Harwerth RS, Hee MR, Huang D, Ioannis Tsinopoulos, Jonas JB, Jonas JB, Jonas JB, Kerrigan-Baumrind LA, Mardin CY, Martin Thiel, Neubauer AS, Pires I, Sanchez-Tocino H, Saruhan A, Vijaya L, Zeimer R, Zeimer RC   +24 more
core   +1 more source

Berberine alleviates cell pyroptosis in diabetic retinopathy by regulating AKT1, JUN, and STAT3

Ibrain, EarlyView.
Berberine alleviates diabetic retinopathy by reducing pyroptosis through AKT1/JUN/STAT3 regulation, as validated in rat models via network pharmacology, molecular docking, and experimental assays. Abstract Berberine (BBR) exerts an effective protection for diabetic retinopathy (DR), but the underlying key molecular mechanism remains unknown; this study
Na Li, Ji‐Lin Chen, Yi‐Jian Sun, Jia‐Fan Sun, Fatin Athirah Pauzi, Song‐Lin Zhu, Amy Yi Hsan Saik, Alan Han‐Kiat Ong   +7 more
wiley   +1 more source

Amyloid-Beta Peptide Is Toxic to Neurons In Vivo via Indirect Mechanisms

Neurobiology of Disease, 2002
We have studied the neurotoxicity of amyloid-beta (Aβ) after a single unilateral intravitreal injection. Within the retina apoptotic cells were seen throughout the photoreceptor layer and the inner nuclear layer but not in the ganglion cell layer at 48 h
Desmond T. Walsh, Rosa M. Montero, Laura G. Bresciani, Angela Y.T. Jen, Pascale D. Leclercq, Debbie Saunders, Ahmed N. EL-Amir, Lukemann Gbadamoshi, Stephen M. Gentleman, Ling-Sun Jen   +9 more
doaj   +1 more source