Results 51 to 60 of about 37,318 (280)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Mathematical modeling of tumor growth and treatment

, 2014
Using mathematical models to simulate dynamic biological processes has a long history. Over the past couple of decades or so, quantitative approaches have also made their way into cancer research.
Chaplain, Mark A. J., Enderling, Heiko
core   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Ocular Toxicity Associated with Tamoxifen Administration in Patients with Breast Cancer: A Systematic Review [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Tamoxifen (TAM), a selective Oestrogen Receptor (ER) modulator, is widely used for treating and preventing ER-positive Breast Cancer (BC). TAM, administered as an adjuvant therapy for hormone receptor-positive BC, reduces recurrence but can
Tejaswi Vadde, Neha Narayan, Amulya Varshini Banka, Shravani Divity, Yethindra Vityala   +4 more
doaj   +1 more source

NF1 mutation drives neuronal activity-dependent initiation of optic glioma [PDF]

, 2021
Neurons have recently emerged as essential cellular constituents of the tumour microenvironment, and their activity has been shown to increase the growth of a diverse number of solid tumours1.
Chang, Kun-Che, James J. Lennon, Yu Ma, Jared D. Hysinger, David H. Gutmann, Lennon, James J, Toonen, Joseph A, Xia, Xin, Michelle Monje, Nicki F. Schindler, Joseph A. Toonen, Mulinyawe, Sara B, Liau, Linda M, Sara B. Mulinyawe, Belgin Yalçın, Guo, Xiaofan, Xiaofan Guo, Kun-Che Chang, Scheaffer, Suzanne, Hysinger, Jared D, Jeffrey L. Goldberg, Corina Anastasaki, Anitha Ponnuswami, Schindler, Nicki F, Anastasaki, Corina, Barron, Tara, Gutmann, David H, Xin Xia, Huguenard, John R, Yuan Pan, Erin M. Gibson, Yalçın, Belgin, Cobb, Olivia, Olivia Cobb, Gibson, Erin M, John R. Huguenard, Ponnuswami, Anitha, Linda M. Liau, Monje, Michelle, Suzanne Scheaffer, Ma, Yu, Goldberg, Jeffrey L, Pan, Yuan, Tara Barron   +43 more
core   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Hereditary Pheochromocytoma as a Major Manifestation of von Hippel Lindau Disease (vHL) in Childhood: Long-term Follow-up of Five Patients with vHL from One Family

JCRPE
Von Hippel-Lindau disease (vHL) is a hereditary, autosomal dominant syndrome manifested by a predisposition to the occurrence of benign and malignant neoplasms.
Katarzyna Pasternak-Pietrzak, Agata Kozłowska, Elżbieta Moszczyńska   +2 more
doaj   +1 more source

Hyperpigmented spots at fundus examination: a new ocular sign in Neurofibromatosis Type I

Orphanet Journal of Rare Diseases, 2021
Background Neurofibromatosis Type I (NF1), also termed von Recklinghausen disease, is a rare genetic disorder that is transmitted by autosomal dominant inheritance, with complete penetrance and variable expressivity.
Antonietta Moramarco, Fabiana Mallone, Marta Sacchetti, Luca Lucchino, Emanuele Miraglia, Vincenzo Roberti, Alessandro Lambiase, Sandra Giustini   +7 more
doaj   +1 more source

Toward Wireless Implantable Robotic Systems Driven by Magnetic Field for Personalized Therapy

Advanced Robotics Research, EarlyView.
Robotic materials are playing an increasingly vital role in enabling sensing and actuation at small scales. This perspective highlights recent advances in magnetic materials and magnetically actuated devices for wireless sensing, actuation, and energy harvesting toward implantable robotic systems for closed‐loop therapy.
Yusheng Wang, Ruijian Ge, Xiaoguang Dong
wiley   +1 more source