Results 181 to 190 of about 402,915 (338)

Deficiency of 2‐Oxoglutarate Carrier (Slc25a11) Drives RPE Epithelial‐to‐Mesenchymal Transition and Exacerbates Subretinal Fibrosis in Neovascular Age‐Related Macular Degeneration

Aging Cell, Volume 24, Issue 12, December 2025.
The diagram shows that OGC deficiency leads to mitochondrial dysfunction, which activates the PI3K/AKT/Slug pathway and triggers epithelial‐mesenchymal transition (EMT) in retinal pigment epithelial cells. This process promotes myofibroblast accumulation and subretinal fibrosis in laser‐induced CNV, contributing to the progression of AMD.
Mo Wang, Feng‐Juan Gao, Wenyi Tang, Boya Lei, Fangyuan Hu, Jun Ma, Srinivas R. Sadda, Ram Kannan, Parameswaran G. Sreekumar, Gezhi Xu   +9 more
wiley   +1 more source

Suppression of Retinal Neovascularization by Lentivirus-Mediated Netrin-1 Small Hairpin RNA [PDF]

, 2011
Huizhuo Xu, Jiaolian Liu, Siqi Xiong, Yun-Zheng Le, Xiaobo Xia   +4 more
openalex   +1 more source

Choroidal changes and association with Gaussian curvature in high myopic eyes with posterior staphyloma in ultra‐wide‐field optical coherence tomography angiography

Acta Ophthalmologica, Volume 103, Issue 8, Page 998-1009, December 2025.
Abstract Purpose To evaluate choroidal changes in high myopic (HM) patients with posterior staphyloma (PS) and explore their association with Gaussian curvature (K) using ultra‐wide‐field optical coherence tomography angiography (UWF‐OCTA). Methods HM patients with wide macular PS (Type I PS) and without any PS (control) were recruited.
Qing Zhao, Linxin Wei, Huan Chen, Yan Luo, Youxin Chen, Zhikun Yang   +5 more
wiley   +1 more source

Transcriptional Comparison of Human and Murine Retinal Neovascularization. [PDF]

Invest Ophthalmol Vis Sci, 2023
Pauleikhoff L, Boneva S, Boeck M, Schlecht A, Schlunck G, Agostini H, Lange C, Wolf J.   +7 more
europepmc   +1 more source

Aqueous humour concentrations of HB‐EGF, EGF and VEGF‐A and axial length in humans

Acta Ophthalmologica, Volume 103, Issue 8, Page 919-928, December 2025.
Abstract Purpose To investigate relationships between the intraocular concentrations of heparin‐binding epidermal growth factor (HB‐EGF), epidermal growth factor (EGF) and vascular endothelial growth factor A (VEGF‐A) in dependence on axial length in humans. Design Clinical interventional cohort study.
Wen‐Da Zhou, Li Dong, Yu‐Hang Yang, Yuan He, Xiao‐Zhen Wang, Han‐Qing Zhao, Rui‐Heng Zhang, Jost B. Jonas, Wen‐Bin Wei   +8 more
wiley   +1 more source

Differential expression of pro- and antiangiogenic factors in mouse strain-dependent hypoxia-induced retinal neovascularization [PDF]

, 2005
Candy King-Chi Chan, Lucia N. Pham, Jiehao Zhou, Christine Spee, Stephen J. Ryan, David R. Hinton   +5 more
openalex   +1 more source

Clinical characteristics and treatment outcomes of bilateral myopic macular neovascularization in high myopic patients

Acta Ophthalmologica, Volume 103, Issue 8, Page 1049-1057, December 2025.
Abstract Purpose To evaluate the clinical features and treatment outcomes of bilateral myopic macular neovascularization (mMNV). Methods This single‐centre retrospective study included patients with bilateral high myopia who were newly diagnosed with unilateral mMNV (first eye) between January 2008 and July 2020.
Soo Hyun Lim, Kunho Bae, Chang Ki Yoon, Eun Kyoung Lee, Kyu Hyung Park, Un Chul Park   +5 more
wiley   +1 more source

AAV2-antiVEGFscFv gene therapy for retinal neovascularization. [PDF]

Mol Ther Methods Clin Dev, 2023
Han N, Xu X, Liu Y, Luo G.
europepmc   +1 more source

Optimizing Collagen Biostimulator Choice in LATAM: Expert Consensus on Patient Selection, Ethnic Skin Phenotypes, and Accessibility

Journal of Cosmetic Dermatology, Volume 24, Issue 12, December 2025.
ABSTRACT Background The diverse ethnic skin phenotypes and socioeconomic landscape of Latin America (LATAM) necessitate tailored approaches to collagen biostimulators, calcium hydroxylapatite (CaHA) and poly‐l‐lactic acid (PLLA). A region‐specific consensus on their optimal use is lacking.
Eugenia Cure, Luis Alberto Parra Hernández, Andreina Martinez Amado, Juan Sebastian Rodriguez Cabrales, Eliana Garcés, Valentina Dicker, Desiree Castelanich, Carolina Schneider, Ingrid Salas, Joselyn Argueta, Lina Velázquez Tafur, Andrea Acevedo, Alejandra Bugallo, Evalicia Murúa, Andrea Marcela Parra Hernandez   +14 more
wiley   +1 more source

Eye‐Targeted A20 Gene Therapy Alleviates Ischemic Retinopathy by Reducing Pathologic Neovascularization, Gliosis, and Neuronal Apoptosis

The FASEB Journal, Volume 39, Issue 22, 30 November 2025.
Eye‐targeted A20 gene therapy alleviates ischemic retinopathy by limiting pathologic neovascularization, reducing gliosis, and protecting from neuronal apoptosis. ABSTRACT Intravitreal administration of anti‐VEGF therapies has been highly beneficial in treating ischemic proliferative retinopathies (PR).
Sanah Essayagh, Tarek Aridi, Tytteli Turunen, Lynn Choi, Hugo Adam, Nyah Patel, Salvatore T. Scali, Mark D. Fisher, Karl Skaf, Eva Csizmadia, Phillip Brennan, Anthony Sadek, Jona Skaf, Michelle Zhan, Emily Hansen, Maryam Shamloo, Nicholas R. DeStefino, Allen C. Clermont, Cleide Angolano, Christiane Ferran   +19 more
wiley   +1 more source