Results 1 to 10 of about 138,851 (338)

Functions and Diseases of the Retinal Pigment Epithelium

Frontiers in Pharmacology, 2021
The retinal pigment epithelium is a fundamental component of the retina that plays essential roles in visual functions. Damage to the structure and function of the retinal pigment epithelium leads to a variety of retinopathies, and there is currently no ...
Song Yang, Jun Zhou, Jun Zhou, Dengwen Li   +3 more
doaj   +2 more sources

Retinal Pigment Epithelium Tear [PDF]

Current Ophthalmology Reports, 2014
Retinal pigment epithelium tear is a potentially vision threatening complication of retinal pigment epithelial detachment associated with neovascular age-related macular degeneration. Retinal pigment epithelium tear has been reported to occur spontaneously and after treatment with anti-vascular growth endothelial factor agents.
Aleksandra V, Rachitskaya, Raquel, Goldhardt   +1 more
openaire   +2 more sources

Morphofunctional retinal pigment epithelium changes in normal eye and age-related macular degeneration

Офтальмохирургия, 2023
Relevance. The retinal pigment epithelium performs a number of highly specialized functions. The relevance of studying morphological changes in the pigment epithelium is associated with an increased number of patients with age-related macular ...
R.R. Fayzrakhmanov, E.D. Bosov, V.A. Bogdanova, E.E. Vaganova, O.L. Sechina   +4 more
doaj   +1 more source

Retinal Pigment Epithelium Lipofuscin Proteomics [PDF]

Molecular & Cellular Proteomics, 2008
Lipofuscin accumulates with age in the retinal pigment epithelium (RPE) in discrete granular organelles and may contribute to age-related macular degeneration. Because previous studies suggest that lipofuscin contains protein that may impact pathogenic mechanisms, we pursued proteomics analysis of lipofuscin.
Kwok-Peng, Ng, Bogdan, Gugiu, Kutralanathan, Renganathan, Matthew W, Davies, Xiaorong, Gu, John S, Crabb, So Ra, Kim, Malgorzata B, Rózanowska, Vera L, Bonilha, Mary E, Rayborn, Robert G, Salomon, Janet R, Sparrow, Michael E, Boulton, Joe G, Hollyfield, John W, Crabb   +14 more
openaire   +2 more sources

MFGE8 does not influence chorio-retinal homeostasis or choroidal neovascularization in vivo [PDF]

, 2012
Purpose: Milk fat globule-epidermal growth factor-factor VIII (MFGE8) is necessary for diurnal outer segment phagocytosis and promotes VEGF-dependent neovascularization.
A Swaroop, AC Bird, Alfred Lewin, Bertrand Calippe, BL Burgess, C Combadiere, CA Augood, Christophe Combadière, Clotilde Théry, CY Hu, DA Tregouet, David-Alexandre Tregouet, DS Friedman, E Nandrot, EF Nandrot, EF Nandrot, Florian Sennlaub, Francine Behar-Cohen, G Sugano, H Baatz, H Kamizuru, Holger Baatz, JD Stubbs, JS Silvestre, K Atabai, K Oshima, Lucie Poupel, M Houssier, M Jinushi, M Paques, N Kwak, Nicole Keller, PD Sasieni, PJ Rosenfeld, PM D'Cruz, R Hanayama, R Hanayama, R Klein, R Klein, RB Edwards, RL Ceriani, RW Young, Salomon-Yves Cohen, SC Finnemann, Serge Camelo, SH Sarks, Sophie Krumeich, Sophie Lavalette, T Vinding, William Raoul, WR Green, X Ding, Xavier Guillonneau   +52 more
core   +11 more sources

Early stages of retinal development depend on Sec13 function [PDF]

, 2013
Summary ER-to-Golgi transport of proteins destined for the extracellular space or intracellular compartments depends on the COPII vesicle coat and is constitutive in all translationally active cells.
Cavodeassi, Florencia, Feng, Yi, Schmidt, Katy, Stephens, David J   +3 more
core   +3 more sources

Profound Re-Organization of Cell Surface Proteome in Equine Retinal Pigment Epithelial Cells in Response to In Vitro Culturing [PDF]

, 2012
The purpose of this study was to characterize the cell surface proteome of native compared to cultured equine retinal pigment epithelium (RPE) cells. The RPE plays an essential role in visual function and represents the outer blood-retinal barrier.
Aisenbrey, Alcazar, Alge, Bhutto, Bodaghi, Burke, Campochiaro, Christoph Szober, Chu, Claudia Alge-Priglinger, Clegg, Cornelia Deeg, Deeg, Deeg, Deeg, Deeg, Deeg, Degroote, Doherty, Dunn, Eberhardt, Ehrenhofer, Greer, Gullapalli, Gundersen, Ham, Hamel, Hauck, Hauck, Hauck, Hauck, Ho, Huang, Karl, Kerstin Euler, Kristina Fröhlich, Li, Limb, Machemer, Marius Ueffing, McBee, Milyushina, Mochizuki, Muramatsu, Nagai, Parker, Philp, Rizzolo, Rotilio, Singer, Stefanie Hauck, Strauss, Vacanti, Wolf, Wu   +54 more
core   +3 more sources

Retinal pigment epithelium degeneration caused by aggregation of PRPF31 and the role of HSP70 family of proteins [PDF]

, 2020
Background Mutations in pre-mRNA splicing factor PRPF31 can lead to retinitis pigmentosa (RP). Although the exact disease mechanism remains unknown, it has been hypothesized that haploinsufficiency might be involved in the ...
Aramburu, Ana, Bhatia, Vaibhav, Bhattacharya, Shom S, Calado, Sofia, Chakarova, Christina, de la Cerda, Berta, Diez-Lloret, Andrea, Díaz-Corrales, Francisco J, García-Delgado, Ana B, Massalini, Simone, Montero-Sánchez, Adoración, Rodríguez-Bocanegra, Eduardo, Rodríguez-Martínez, Daniel, Valdés-Sánchez, Lourdes   +13 more
core   +2 more sources

Advances in the treatment of rhegmatogenous retinal detachment [PDF]

International Journal of Ophthalmology, 2019
The pathogenesis of rhegmatogenous retinal detachment depends on three factors, namely, retinal rupture, vitreous liquefaction and traction causing the retina to separate from the pigment epithelium, among which retinal rupture is the most important ...
Li Liao, Xiao-Hua Zhu
doaj   +1 more source

Modern trends in diagnostics and prediction of results of anti-vascular endothelial growth factor therapy of pigment epithelial detachment in neovascular agerelated macular degeneration using deep machine learning method (literature review)

Acta Biomedica Scientifica, 2021
Detachment of the pigment epithelium is the separation of the basement membrane of the retinal pigment epithelium from the inner collagen layer of Bruch’s membrane, which occurs in 80 % of cases in patients with neovascular age-related macular ...
E. V. Kozina, S. N. Sakhnov, V. V. Myasnikova, E. V. Bykova, L. E. Aksenova   +4 more
doaj   +1 more source