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Functions and Diseases of the Retinal Pigment Epithelium [PDF]
Frontiers in Pharmacology, 2021 The retinal pigment epithelium is a fundamental component of the retina that plays essential roles in visual functions. Damage to the structure and function of the retinal pigment epithelium leads to a variety of retinopathies, and there is currently no ...
Song Yang +3 more
doaj +6 more sources
The cell biology of the retinal pigment epithelium [PDF]
Progress in Retinal and Eye Research, 2020 The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells, strategically situated between the photoreceptors and the choroid, is the primary caretaker of photoreceptor health and function. Dysfunction of the RPE underlies many inherited and acquired diseases that cause permanent blindness.
Aparna Lakkaraju +6 more
semanticscholar +5 more sources
eLife, 2017 Here we report multiple lines of evidence for a comprehensive model of energy metabolism in the vertebrate eye. Metabolic flux, locations of key enzymes, and our finding that glucose enters mouse and zebrafish retinas mostly through photoreceptors ...
Mark A Kanow +16 more
doaj +2 more sources
Neural Regeneration Research, 2023 Age-related macular degeneration is a primary cause of blindness in the older adult population. Past decades of research in the pathophysiology of the disease have resulted in breakthroughs in the form of anti-vascular endothelial growth factor therapies
M. Maurya +6 more
semanticscholar +1 more source
Sodium iodate induces ferroptosis in human retinal pigment epithelium ARPE-19 cells
Cell Death and Disease, 2021 Sodium iodate (SI) is a widely used oxidant for generating retinal degeneration models by inducing the death of retinal pigment epithelium (RPE) cells. However, the mechanism of RPE cell death induced by SI remains unclear. In this study, we investigated
Binghua Liu +11 more
semanticscholar +1 more source
Nature Communications, 2021 There are currently no treatments for geographic atrophy, the advanced form of age-related macular degeneration. Hence, innovative studies are needed to model this condition and prevent or delay its progression.
A. Senabouth +29 more
semanticscholar +1 more source
Retinal Pigment Epithelium Tear [PDF]
Current Ophthalmology Reports, 2014 Retinal pigment epithelium tear is a potentially vision threatening complication of retinal pigment epithelial detachment associated with neovascular age-related macular degeneration. Retinal pigment epithelium tear has been reported to occur spontaneously and after treatment with anti-vascular growth endothelial factor agents.
Raquel Goldhardt, Aleksandra Rachitskaya
openaire +3 more sources
Офтальмохирургия, 2023 Relevance. The retinal pigment epithelium performs a number of highly specialized functions. The relevance of studying morphological changes in the pigment epithelium is associated with an increased number of patients with age-related macular ...
R.R. Fayzrakhmanov +4 more
doaj +1 more source
Role of Epithelial-Mesenchymal Transition in Retinal Pigment Epithelium Dysfunction
Frontiers in Cell and Developmental Biology, 2020 Retinal pigment epithelial (RPE) cells maintain the health and functional integrity of both photoreceptors and the choroidal vasculature. Loss of RPE differentiation has long been known to play a critical role in numerous retinal diseases, including ...
Mi Zhou +6 more
semanticscholar +1 more source
Clinical and Experimental Ophthalmology, 2020 Age‐related macular degeneration (AMD) is a progressive degenerative disease that is the leading cause of vision loss in the elderly population.
Shreya Somasundaran +3 more
semanticscholar +1 more source