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Functions and Diseases of the Retinal Pigment Epithelium [PDF]
Frontiers in Pharmacology, 2021 The retinal pigment epithelium is a fundamental component of the retina that plays essential roles in visual functions. Damage to the structure and function of the retinal pigment epithelium leads to a variety of retinopathies, and there is currently no ...
Song Yang, Jun Zhou, Dengwen Li
exaly +8 more sources
Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye [PDF]
eLife, 2017 Here we report multiple lines of evidence for a comprehensive model of energy metabolism in the vertebrate eye. Metabolic flux, locations of key enzymes, and our finding that glucose enters mouse and zebrafish retinas mostly through photoreceptors ...
Mark A Kanow +16 more
doaj +4 more sources
Identification of a synergistic interaction between endothelial cells and retinal pigment epithelium [PDF]
Journal of Cellular and Molecular Medicine, 2017 The retinal pigment epithelium located between the neurosensory retina and the choroidal vasculature is critical for the function and maintenance of both the photoreceptors and underlying capillary endothelium.
Kevin J Mchugh +2 more
exaly +4 more sources
The cell biology of the retinal pigment epithelium [PDF]
Progress in Retinal and Eye Research, 2020 The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells, strategically situated between the photoreceptors and the choroid, is the primary caretaker of photoreceptor health and function. Dysfunction of the RPE underlies many inherited and acquired diseases that cause permanent blindness.
Aparna Lakkaraju +6 more
openaire +4 more sources
Deficiency in Lyst function leads to accumulation of secreted proteases and reduced retinal adhesion [PDF]
PLoS ONE, 2022 Chediak–Higashi syndrome, caused by mutations in the Lysosome Trafficking Regulator (Lyst) gene, is a recessive hypopigmentation disorder characterized by albinism, neuropathies, neurodegeneration, and defective immune responses, with enlargement of ...
Xiaojie Ji +8 more
doaj +5 more sources
Nature Communications, 2021 There are currently no treatments for geographic atrophy, the advanced form of age-related macular degeneration. Hence, innovative studies are needed to model this condition and prevent or delay its progression.
A. Senabouth +29 more
semanticscholar +1 more source
Retinal Pigment Epithelium Tear [PDF]
Current Ophthalmology Reports, 2014 Retinal pigment epithelium tear is a potentially vision threatening complication of retinal pigment epithelial detachment associated with neovascular age-related macular degeneration. Retinal pigment epithelium tear has been reported to occur spontaneously and after treatment with anti-vascular growth endothelial factor agents.
Raquel Goldhardt, Aleksandra Rachitskaya
openaire +3 more sources
Офтальмохирургия, 2023 Relevance. The retinal pigment epithelium performs a number of highly specialized functions. The relevance of studying morphological changes in the pigment epithelium is associated with an increased number of patients with age-related macular ...
R.R. Fayzrakhmanov +4 more
doaj +1 more source
Role of Epithelial-Mesenchymal Transition in Retinal Pigment Epithelium Dysfunction
Frontiers in Cell and Developmental Biology, 2020 Retinal pigment epithelial (RPE) cells maintain the health and functional integrity of both photoreceptors and the choroidal vasculature. Loss of RPE differentiation has long been known to play a critical role in numerous retinal diseases, including ...
Mi Zhou +6 more
semanticscholar +1 more source
Clinical and Experimental Ophthalmology, 2020 Age‐related macular degeneration (AMD) is a progressive degenerative disease that is the leading cause of vision loss in the elderly population.
Shreya Somasundaran +3 more
semanticscholar +1 more source