Results 131 to 140 of about 66,016 (272)

Stage‐Associated Microglial Subpopulations and Dynamics in Vascular Pathogenesis of Oxygen‐Induced Retinopathy

Cell Proliferation, EarlyView.
In the oxygen‐induced retinopathy (OIR) mouse model, two distinct microglial subpopulations play opposing roles: highly glycolytic microglia (HGM) promote neovascular formation via Pkm2, while Mrc1/CD206‐positive phagocytosis‐associated microglia (PAM) facilitate its regression.
Yuan Ma, Ziye Chen, Baoyi Liu, Wen Ding, Runping Duan, Kangjie Kong, Zhuojun Xu, Jizhu Li, Jiali Ru, Dianlei Guo, Xiaoyue Wei, Yaping Liu, Zhuangling Lin, Yang Meng, Yuan Liu, Lan Jiang, Zitong Chen, Rebiya Tuxun, Chinling Tsai, Chunqiao Liu, Tao Li   +20 more
wiley   +1 more source

Direct delivery of Cas9 or base editor protein and guide RNA complex enables genome editing in the retina

Molecular Therapy: Nucleic Acids
Genome editing by CRISPR-Cas holds promise for the treatment of retinal dystrophies. For therapeutic gene editing, transient delivery of CRISPR-Cas9 is preferable to viral delivery which leads to long-term expression with potential adverse consequences ...
Juliette Pulman, Catherine Botto, Hugo Malki, Duohao Ren, Paul Oudin, Anne De Cian, Marie As, Charlotte Izabelle, Bruno Saubamea, Valerie Forster, Stéphane Fouquet, Camille Robert, Céline Portal, Aziz El-Amraoui, Sylvain Fisson, Jean-Paul Concordet, Deniz Dalkara   +16 more
doaj   +1 more source

Ultrasound-targeted microbubble destruction enhances AAV mediated gene transfection: human RPE cells in vitro and the rat retina in vivo

, 2009
The present study was performed to investigate the efficacy and safety of Ultrasound-targeted microbubble destruction (UTMD) mediated rAAV2-EGFP to cultured human retinal pigment epithelium (RPE) cells _in vitro_ and the rat retina _in vivo_.
Xiaozhi Zheng, Huiping Wang, Ying Wu, Lianfang Du, Hongli Li, Fan Li   +5 more
core  

INTACT RETINAL TISSUE AND RETINAL PIGMENT EPITHELIUM IDENTIFIED WITHIN A COLOBOMA BY HIGH-SPEED, ULTRAHIGH-RESOLUTION OPTICAL COHERENCE TOMOGRAPHY

, 2011
Purpose—To report on a posterior segment coloboma manifesting unusual morphology as determined by high-speed, ultrahigh resolution optical coherence tomography imaging (hsUHROCT). Methods—A 47-year-old patient with bilateral colobomas was evaluated via
Vuong, Laurel N., Duker, Jay S, Gorczynska, Iwona M, Judson, Christopher H, Srinivasan, Vivek J., Fujimoto, James G   +5 more
core   +1 more source

Retinoic Acid Signalling Regulates Zebrafish Tooth Germ Repair Following Injury

Cell Proliferation, EarlyView.
Retinoic acid signalling may regulate the repair processes in a tooth germ injury model using Tg(scpp5:Dendra2‐NTR) zebrafish and the nitroreductase (NTR)/metronidazole (MTZ) system. ABSTRACT Although the role of retinoic acid (RA) signalling in odontogenesis is well established, its involvement in the repair of injured tooth germs remains unclear.
Qiqi Liu, Zhenan Zhang, Weifeng Hao, Chunyan Zhou, Deqin Yang   +4 more
wiley   +1 more source

Retinal Pigment Epithelium and Macular Diseases

, 1998
This volume of Documenta Ophthalmologica Proceedings Series collects the scientific papers presented at the 2nd International Symposium on Retinal Pigment Epithelium and the 4th Meeting of the European Macula Group held in Genoa, May 29-June 1, 1996. The
Coscas, Gabriel, Piccolino, Felice Cardillo   +1 more
core   +1 more source

Age and disease-related structural changes in the retinal pigment epithelium

, 2008
Vera L BonilhaCole Eye Institute, The Cleveland Clinic, Cleveland, OH, USAAbstract: As the retinal pigment epithelium (RPE) ages, a number of structural changes occur, including loss of melanin granules, increase in the density of residual bodies ...
Vera L Bonilha
core  

The positive correlation between the progressive photoreceptor damage and the increased macular leakage indicating the severity of diabetic retinopathy

Journal of Diabetes Investigation, EarlyView.
The dark area of photoreceptor cells, as measured by adaptive optics laser scanning ophthalmoscopy, shows significant enlargement with the progression of diabetic retinopathy (DR). A similar trend is observed for macular vascular leakage assessed by fundus fluorescein angiography. A positive correlation exists between these two parameters, suggesting a
Qi Fang, Bingjie Qiu, Xinyue Xu, Wei Jia, Ru Wang, Qianfeng Wang, Wei Qiang, Lei Zhang, Jingfa Zhang, Haiyan Wang   +9 more
wiley   +1 more source

Viral vector-mediated RNA interference in the retina

, 2010
RNA interference (RNAi) is a highly conserved post-transcriptional gene silencing process triggered by double-stranded RNA (dsRNA) in eukaryotic cells.
Georgiadis, A.
core  

Ocular Manifestations of Infectious Salmon Anaemia Virus Infection in Atlantic Salmon (Salmo salar)

Journal of Fish Diseases, EarlyView.
ABSTRACT Eyes are essential sensory organs needed by teleost Atlantic salmon for high visual acuity and survival in both the wild and in aquaculture settings. In this work, we assessed the ocular manifestations of Infectious Salmon Anaemia Virus (ISAV) infection in Atlantic salmon by a cohabitation‐mediated infection assay and histological and ...
Emily Mahon, Rebecca R. Kwabiah, Hélène Paradis, Manuel A. Soto‐Dávila, Sathees Duglas, Raja Ram Gurung, Thurka Paramanathan, Ignacio Vasquez, Shams Al‐Badoosh, John Law, Javier Santander, Mark D. Fast, Robert L. Gendron   +12 more
wiley   +1 more source