Results 201 to 210 of about 91,639 (372)

Evaluating the Therapeutic Potential of Superoxide Dismutase in a Rat Model of Wet Age‐Related Macular Degeneration

open access: yesFASEB BioAdvances, EarlyView.
Oral Superoxide Dismutase Therapy Mitigates Choroidal Neovascularization in a Laser‐Induced Rat Model of Wet Age‐Related Macular Degeneration. Oral Administration of GF103, a Superoxide Dismutase From Bacillus amyloliquefaciens, Reduces Choroidal Neovascularization (CNV) in a Laser‐Induced CNV Rat Model.
Hyun Chul Jeong   +4 more
wiley   +1 more source

Vision at high latitudes: High sensitivity without specific boreal adaptations in photoreception in reindeer (Rangifer tarandus L.)

open access: yesFunctional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract The light climate at high latitudes, in particular the extended twilight of winter and the reduced diel variation in light level in midsummer and midwinter, potentially constrains visual function and the synchronisation of temporal organisation in polar species. In this
Nicholas J. C. Tyler   +3 more
wiley   +1 more source

The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina

open access: yesCell Reports, 2017
Summary: Notch signaling in neural progenitor cell is triggered by ligands expressed in adjacent cells. To identify the sources of active Notch ligands in the mouse retina, we negatively regulated Notch ligand activity in various neighbors of retinal ...
Taejeong Ha   +8 more
doaj  

Expression and Differential Polarization of the Reduced-folate Transporter-1 and the Folate Receptor α in Mammalian Retinal Pigment Epithelium [PDF]

open access: hybrid, 2000
Christy D. Chancy   +8 more
openalex   +1 more source

Retinal pigment epithelium polarity in health and blinding diseases.

open access: yesCurrent Opinion in Cell Biology, 2020
P. Caceres, E. Rodriguez-Boulan
semanticscholar   +1 more source

Cellular Senescence Contributes to the Dysfunction of Tight Junctions in Submandibular Glands of Aging Mice

open access: yesAging Cell, EarlyView.
In aging mice, the submandibular gland, among the three major salivary glands (submandibular, parotid, and sublingual glands), shows a significant increase in senescent cells. This increase disrupts tight junction structures and is closely linked to aging‐related declines in salivary secretion.
Zhuo Chen   +8 more
wiley   +1 more source

Preclinical Evaluation of a Cell-Based Gene Therapy Using the Sleeping Beauty Transposon System in Choroidal Neovascularization

open access: yesMolecular Therapy: Methods & Clinical Development, 2019
Age-related macular degeneration (AMD) is a progressive retinal disorder characterized by imbalanced pro- and antiangiogenic signals. The aim of this study was to evaluate the effect of ex vivo cell-based gene therapy with stable expression of human ...
Maria Hernandez   +18 more
doaj  

Differential Organ Ageing Is Associated With Age‐Related Macular Degeneration

open access: yesAging Cell, EarlyView.
Using the UK Biobank, this study trained neural networks to estimate the biological age of individuals according to markers of organ function. Computing the difference between the estimated organ age and chronological age yielded an estimate for accelerated or slowed ageing.
Anastasios Papadam   +2 more
wiley   +1 more source

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