Results 21 to 30 of about 142,219 (404)
Journal of Tissue Engineering, 2016 The retinal pigment epithelium is an important part of the vertebrate eye, particularly in studying the causes and possible treatment of age-related macular degeneration.
Aaron H Fronk, Elizabeth Vargis
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Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance The retinal pigment epithelium and the choroid are complex tissues whose dysfunction can lead to irreversible visual loss. In this study, single-cell RNA sequencing of both of these tissues was performed to characterize gene expression ...
Andrew P. Voigt +8 more
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Basic and Clinical Neuroscience, 2021 Introduction: Neurosphere-free transdifferentiation of bone marrow stem cells into Retinal Pigment Epithelium (RPE) and Retinal Cells (RCs) in vitro could offer an exceptional opportunity to study cell replacement in degenerative eye diseases.
Hamid AboutalebKadkhodaeian +2 more
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Hamartomas of the Retina and Optic Disc
Türk Oftalmoloji Dergisi, 2022 Hamartomas are local malformation of cells that demonstrate abnormal proliferation in the area where they are normally present. Retinal and optic disc hamartomas include astrocytic hamartoma, congenital hypertrophy of the retinal pigment epithelium ...
Ibadulla Mirzayev, Ahmet Kaan Gündüz
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Science Translational Medicine, 2019 A retinal pigment epithelial patch derived from mutation-free pluripotent stem cells shows therapeutic effects in rats and pigs. A pipeline for retinal stem cell therapy Autologous induced pluripotent stem cell (iPSC)–derived retinal pigment epithelium ...
Ruchi Sharma +25 more
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Setting Eyes on the Retinal Pigment Epithelium [PDF]
Frontiers in Cell and Developmental Biology, 2018 The neural component of the zebrafish eye derives from a small group of cells known as the eye/retinal field. These cells, positioned in the anterior neural plate, rearrange extensively and generate the optic vesicles (OVs). Each vesicle subsequently folds over itself to form the double-layered optic cup, from which the mature eye derives.
Tania Moreno-Marmol +4 more
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Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light responsiveness of human pluripotent stem cell derived retinal organoids [PDF]
, 2019 Tissue specific extracellular matrices (ECM) provide structural support and enable access to molecular signals and metabolites, which are essential for directing stem cell renewal and differentiation.
Al-Aama, Jumana +15 more
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Deficiency in Lyst function leads to accumulation of secreted proteases and reduced retinal adhesion
PLoS ONE, 2022 Chediak–Higashi syndrome, caused by mutations in the Lysosome Trafficking Regulator (Lyst) gene, is a recessive hypopigmentation disorder characterized by albinism, neuropathies, neurodegeneration, and defective immune responses, with enlargement of ...
Xiaojie Ji +8 more
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Adenocarcinoma of retinal pigment epithelium. [PDF]
British Journal of Ophthalmology, 1987 This report describes a 41-year-old man with an intraocular tumour misinterpreted clinically as choroidal melanoma. The fluorescein angiographic features were not fully characteristic of uveal malignancy, and indeed histopathology revealed the diagnosis of adenocarcinoma of the retinal pigment epithelium.
P Dhermy +5 more
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Sustained gene expression in the retina by improved episomal vectors [PDF]
, 2014 Gene and cellular therapies are nowadays part of therapeutic strategies for the treatment of diverse pathologies. The drawbacks associated with gene therapy-low levels of transgene expression, vector loss during mitosis, and gene silencing-need to be ...
Ana V. Oliveira +7 more
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