Results 21 to 30 of about 138,851 (338)

Phagocytosis by the Retinal Pigment Epithelium: Recognition, Resolution, Recycling

Frontiers in Immunology, 2020
Tissue-resident phagocytes are responsible for the routine binding, engulfment, and resolution of their meals. Such populations of cells express appropriate surface receptors that are tailored to recognize the phagocytic targets of their niche and ...
Whijin Kwon, S. Freeman
semanticscholar   +1 more source

Scaffolds for retinal pigment epithelial cell transplantation in age-related macular degeneration

Journal of Tissue Engineering, 2017
In several retinal degenerative diseases, including age-related macular degeneration, the retinal pigment epithelium, a highly functionalized cell monolayer, becomes dysfunctional.
Corina E White, Ronke M Olabisi
doaj   +1 more source

Methods for culturing retinal pigment epithelial cells: a review of current protocols and future recommendations

Journal of Tissue Engineering, 2016
The retinal pigment epithelium is an important part of the vertebrate eye, particularly in studying the causes and possible treatment of age-related macular degeneration.
Aaron H Fronk, Elizabeth Vargis
doaj   +1 more source

Nel positively regulates the genesis of retinal ganglion cells by promoting their differentiation and survival during development [PDF]

, 2014
Peer reviewedPublisher ...
Adams JC, Agathocleous M, Aihara K, Amy S. Findlay, Austin CP, Cayouette M, Cepko CL, Chizu Nakamoto, de Iongh R, Ehrlich D, Elaine Durward, Ewa D. Zakrzewska, Fekete DM, Flanagan JG, Frade JM, Galvez JM, Hansen MJ, Harada H, Harpavat S, Hashimoto T, Holt CE, Hu WY, Isenmann S, Jablonski MM, Jablonski MM, Jiang Y, Jiang Y, Katahira T, Koga A, Kuroda S, Layer PG, Marianne Bronner, Martinez-Morales JR, Masai I, Masaru Nakamoto, Matsuhashi S, Matsuhashi S, Matsuoka H, Matsuyama S, Matsuyama S, McCabe KL, McCabe KL, McLaughlin T, Moore SW, Munemasa Y, Nakamura R, Nelson BR, Nelson BR, Oyasu M, Patel A, Prada C, Price J, Rachel RA, Raymond SM, Sato Y, Snow RL, Soh-Leh Kuan, Stiemke MM, Strauss O, Takuma Endo, Wang JT, Watanabe TK, Wetts R, Xiang M, Yee JK, Zhang XM, Zhang XM, Zhufeng Ouyang   +67 more
core   +1 more source

Deficiency in Lyst function leads to accumulation of secreted proteases and reduced retinal adhesion.

PLoS ONE, 2022
Chediak-Higashi syndrome, caused by mutations in the Lysosome Trafficking Regulator (Lyst) gene, is a recessive hypopigmentation disorder characterized by albinism, neuropathies, neurodegeneration, and defective immune responses, with enlargement of ...
Xiaojie Ji, Lihong Zhao, Ankita Umapathy, Bernard Fitzmaurice, Jieping Wang, David S Williams, Bo Chang, Jürgen K Naggert, Patsy M Nishina   +8 more
doaj   +3 more sources

Neurosphere-Free Transdifferentiation of Rat Bone Marrow Stromal Stem Cells Into Retinal Cells and Retinal Pigment Epithelium

Basic and Clinical Neuroscience, 2021
Introduction: Neurosphere-free transdifferentiation of bone marrow stem cells into Retinal Pigment Epithelium (RPE) and Retinal Cells (RCs) in vitro could offer an exceptional opportunity to study cell replacement in degenerative eye diseases.
Hamid AboutalebKadkhodaeian, Hamidreza Sameni, Ali Shahbazi   +2 more
doaj  

Hamartomas of the Retina and Optic Disc

Türk Oftalmoloji Dergisi, 2022
Hamartomas are local malformation of cells that demonstrate abnormal proliferation in the area where they are normally present. Retinal and optic disc hamartomas include astrocytic hamartoma, congenital hypertrophy of the retinal pigment epithelium ...
Ibadulla Mirzayev, Ahmet Kaan Gündüz
doaj   +1 more source

Sustained gene expression in the retina by improved episomal vectors [PDF]

, 2014
Gene and cellular therapies are nowadays part of therapeutic strategies for the treatment of diverse pathologies. The drawbacks associated with gene therapy-low levels of transgene expression, vector loss during mitosis, and gene silencing-need to be ...
Ana V. Oliveira, Conley S.M., Davis A.A., Gabriela A. Silva, Reinisalo M., Rudolf Haase, Sofia M. Calado, Susana Machado   +7 more
core   +1 more source

Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance The retinal pigment epithelium and the choroid are complex tissues whose dysfunction can lead to irreversible visual loss. In this study, single-cell RNA sequencing of both of these tissues was performed to characterize gene expression ...
Andrew P. Voigt, Kelly Mulfaul, Nathaniel K. Mullin, Miles J. Flamme-Wiese, Joseph C. Giacalone, E. Stone, B. Tucker, T. Scheetz, R. Mullins   +8 more
semanticscholar   +1 more source

Spectral Domain Optical Coherence Tomography in Simple Retina Pigment Epithelium Hamartoma

Türk Oftalmoloji Dergisi, 2012
To report the spectral-domain optical coherence tomographic findings in a case of a simple hamartoma of the retinal pigment epithelium. A 55-year-old female patient with simple hamartoma of the retinal pigment epithelium was evaluated with ...
Melis Palamar Onay, Ayşe Yağcı
doaj   +1 more source