Results 291 to 300 of about 91,639 (372)

Bestrophin 1 is indispensable for volume regulation in human retinal pigment epithelium cells

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2015
Andrea Milenkovic   +13 more
semanticscholar   +1 more source

Mitochondrial Mutation Leads to Cardiomyocyte Hypertrophy by Disruption of Mitochondria‐Associated ER Membrane

open access: yesCell Proliferation, EarlyView.
Cardiomyocytes with high m.3243A>G burden exhibited hypertrophic phenotype. Mitochondria dysfunction occurred and tended to become round in cardiomyocytes with high m.3243A>G burden. Mitochondria‐associated ER membrane (MAM) was disrupted in cardiomyocytes with high m.3243A>G burden.
Miao Yu   +10 more
wiley   +1 more source

Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium

open access: yesAutophagy, 2015
Jingyu Yao   +10 more
semanticscholar   +1 more source

PD‐L1 Promotes Immunological Tolerance and Enhances Visual Protection of hESC‐RPE Grafts in Retinal Degeneration

open access: yesCell Proliferation, EarlyView.
We generated immune‐tolerant mature hESC‐RPE cells by overexpressing PD‐L1. PD‐L1‐expressing hESC‐RPE grafts exhibited significantly higher survival, reduced apoptosis and enhanced visual protection in retinal degeneration models, which presents an alternative target to improve the efficiency of hESC‐RPE‐based therapy for AMD. ABSTRACT Immune rejection
Bowen Li   +11 more
wiley   +1 more source

Treatment of Macular Degeneration Using Embryonic Stem Cell-Derived Retinal Pigment Epithelium: Preliminary Results in Asian Patients

open access: yesStem Cell Reports, 2015
W. Song   +8 more
semanticscholar   +1 more source

Intelligent Manufacturing for Osteoarthritis Organoids

open access: yesCell Proliferation, EarlyView.
Overall schematic of intelligent manufacturing in osteoarthritis organoids. Broad overview of the article's structure, outlining the progression from fundamental joint anatomy and OA pathogenesis to organoid construction and, ultimately, to intelligent manufacturing and future prospects.
Xukun Lyu, Jian Wang, Jiacan Su
wiley   +1 more source

YY2 mediates transcriptional repression of PHGDH and expedites oxidative stress in retinal pigment epithelial cells in diabetic retinopathy

open access: yesJournal of Diabetes Investigation, EarlyView.
The expression of YY2 was significantly elevated in diabetic retinopathy, and YY2 blocked the serine synthesis pathway in retinal epithelial cells by inhibiting the transcriptional expression of PHGDH, thereby inducing the progression of oxidative stress and ferroptosis in the cells.
Xiang Lei, Xiu Wang, Xinai Zhang
wiley   +1 more source

In situ quantification of ribosome number by electron tomography

open access: yesJournal of Microscopy, EarlyView.
Abstract Ribosomes, discovered in 1955 by George Palade, were initially described as small cytoplasmic particles preferentially associated with the endoplasmic reticulum (ER). Over the years, extensive research has focused on both the structure and function of ribosomes.
Mounir El Hankouri   +4 more
wiley   +1 more source

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