Results 51 to 60 of about 142,219 (404)

A Single-Cell Transcriptome Atlas of the Human Retinal Pigment Epithelium

Frontiers in Cell and Developmental Biology, 2021
Human retinal pigment epithelium cells are arranged in a monolayer that plays an important supporting role in the retina. Although the heterogeneity of specific retinal cells has been well studied, the diversity of hRPE cells has not been reported. Here,
Zongren Xu, Zongren Xu, Zongren Xu, Zongren Xu, Xingyun Liao, Xingyun Liao, Xingyun Liao, Xingyun Liao, Na Li, Hongxiu Zhou, Hongxiu Zhou, Hongxiu Zhou, Hong Li, Hong Li, Hong Li, Qi Zhang, Qi Zhang, Qi Zhang, Ke Hu, Ke Hu, Ke Hu, Peizeng Yang, Peizeng Yang, Peizeng Yang, Peizeng Yang, Shengping Hou, Shengping Hou, Shengping Hou, Shengping Hou   +28 more
doaj   +1 more source

Ocular immune privilege and retinal pigment epithelial cells.

Journal of Leukocyte Biology, 2023
The ocular tissue microenvironment is immune-privileged and uses multiple immunosuppressive mechanisms to prevent the induction of inflammation. The retinal pigment epithelium plays an essential role in ocular immune privilege.
Yuxiang Du, Bo Yan
semanticscholar   +1 more source

The Cytoskeleton of the Retinal Pigment Epithelium: from Normal Aging to Age-Related Macular Degeneration

International Journal of Molecular Sciences, 2019
The retinal pigment epithelium (RPE) is a unique epithelium, with major roles which are essential in the visual cycle and homeostasis of the outer retina.
I. Ţărău, Andreas Berlin, C. Curcio, T. Ach   +3 more
semanticscholar   +1 more source

The Epidemiology of Stargardt Disease in the United Kingdom [PDF]

, 2017
The authors thank the British Ophthalmological Surveillance Unit (BOSU) for the support received, as well as Mr Barnaby Foot, research coordinator for BOSU, for his help and advice on this project.
Bainbridge, James, Downes, Susan, Ho, Jason, Lois, Noemi, Scott, Neil W, Spiteri Cornish, Kurt   +5 more
core   +2 more sources

Advances in the study of tissue-engineered retinal pigment epithelial cell sheets

Regenerative Therapy
Regarded as the most promising treatment modality for retinal degenerative diseases, retinal pigment epithelium cell replacement therapy holds significant potential.
Wang Zhou, Yujiao Chai, Shan Lu, Qiaohui Yang, Liying Tang, Di Zhou   +5 more
doaj   +1 more source

Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration

eLife, 2019
Age-related macular degeneration (AMD) is a progressive disease of the retinal pigment epithelium (RPE) and the retina leading to loss of central vision.
F. Storti, Katrin Klee, V. Todorova, Regula Steiner, A. Othman, S. D. van der Velde-Visser, M. Samardzija, I. Meneau, M. Barben, D. Karademir, Valda Pauzuolyte, S. Boye, Frank Blaser, C. Ullmer, J. Dunaief, T. Hornemann, L. Rohrer, A. D. den Hollander, A. von Eckardstein, J. Fingerle, C. Maugeais, C. Grimm   +21 more
semanticscholar   +1 more source

Restoring Retinal Function in a Mouse Model of Hereditary Blindness [PDF]

, 2005
Moore discusses a new study showing rescue of photoreceptor function using gene and drug therapies in a mouse model of Leber congenital ...
Moore, Tony
core   +4 more sources

Selective Laser Sintering 3D Printing of Drug‐Loaded Intravitreal Implants

Advanced Functional Materials, EarlyView.
Selective laser sintering enables the fabrication of biodegradable and biocompatible intravitreal implants with tunable microstructures for sustained drug delivery. By modulating laser scanning speed, the polymer matrix architecture is engineered to control the release kinetics of dexamethasone and riboflavin over several months. This approach offers a
Iria Seoane‐Viaño, Carlos Bendicho‐Lavilla, Haya Alfassam, Bárbara Blanco‐Fernández, Abdul W. Basit, Francisco J. Otero‐Espinar   +5 more
wiley   +1 more source

Single-channel recordings from cultured human retinal pigment epithelial cells. [PDF]

, 1988
We have applied patch-clamp techniques to on-cell and excised-membrane patches from human retinal pigment epithelial cells in tissue culture. Single-channel currents from at least four ion channel types were observed: three or more potassium-selective ...
Fain, GL, Fox, JA, Pfeffer, BA
core  

Methotrexate‐Loaded Liposomal Formulation Enables 6‐Week Sustained Intraocular Therapeutic Drug Release in a Porcine Model

Advanced Healthcare Materials, EarlyView.
A liposomal formulation for methotrexate enables minimally invasive, sustained intraocular drug delivery for over six weeks with a single injection. Developed for treating intraocular diseases like lymphoma and PVR, it offers excellent biocompatibility in vivo in a porcine model.
Maximilian Hammer, Lea Skrzypczyk, Sabrina Wohlfart, Bryan Calder Ackermann, Ludwig Geisweid, Simon William Pohl, Margarita Karaivanova, Jonathan Herth, Victor Aristide Augustin, Alexander Studier‐Fischer, Tina Sackmann, Leon Kaulen, Anna Steyer, Walter Mier, David H Steel, Kanmin Xue, Gerd Uwe Auffarth, Philipp Uhl   +17 more
wiley   +1 more source