Results 51 to 60 of about 91,639 (372)
eLife, 2019 Age-related macular degeneration (AMD) is a progressive disease of the retinal pigment epithelium (RPE) and the retina leading to loss of central vision.
F. Storti +21 more
semanticscholar +1 more source
A Single-Cell Transcriptome Atlas of the Human Retinal Pigment Epithelium
Frontiers in Cell and Developmental Biology, 2021 Human retinal pigment epithelium cells are arranged in a monolayer that plays an important supporting role in the retina. Although the heterogeneity of specific retinal cells has been well studied, the diversity of hRPE cells has not been reported. Here,
Zongren Xu +28 more
doaj +1 more source
A Novel HDL-Mimetic Peptide HM-10/10 Protects RPE and Photoreceptors in Murine Models of Retinal Degeneration. [PDF]
, 2019 Age-related macular degeneration (AMD) is a leading cause of blindness in the developed world. The retinal pigment epithelium (RPE) is a critical site of pathology in AMD. Oxidative stress plays a key role in the development of AMD.
Araujo, Eduardo +10 more
core +2 more sources
International Journal of Molecular Sciences, 2019 The retinal pigment epithelium (RPE) is a unique epithelium, with major roles which are essential in the visual cycle and homeostasis of the outer retina.
I. Ţărău +3 more
semanticscholar +1 more source
Foveal simple hamartoma of retinal pigment epithelium
TNOA Journal of Ophthalmic Science and Research, 2018 Congenital anomalies of retinal pigment epithelium (RPE) are rare entities among which simple hamartoma of RPE is extremely rare. Majority of reported cases of congenital simple hamartoma were extrafoveal and patients were asymptomatic. These lesions may
Prabu Baskaran +2 more
doaj +1 more source
Early stages of retinal development depend on Sec13 function [PDF]
, 2013 Summary ER-to-Golgi transport of proteins destined for the extracellular space or intracellular compartments depends on the COPII vesicle coat and is constitutive in all translationally active cells.
Cavodeassi, Florencia +3 more
core +2 more sources
Mass spectrometry in ocular drug research
Mass Spectrometry Reviews, EarlyView., 2023 Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo +6 more
wiley +1 more source
Stimulation of AMPK prevents degeneration of photoreceptors and the retinal pigment epithelium
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance In this paper, we show that stimulation of adenosine monophosphate-activated protein kinase (AMPK) by metformin is able to protect photoreceptors and the retinal pigmented epithelium (RPE) in three different mouse models of retinal ...
Lei Xu, Li Kong, Jian-gang Wang, J. Ash
semanticscholar +1 more source
Effects of extracellular Ca++, K+, and Na+ on cone and retinal pigment epithelium retinomotor movements in isolated teleost retinas. [PDF]
, 1984 We have examined the effects of changes in extracellular ionic composition on cone and retinal pigment epithelium (RPE) retinomotor movements in cultured isolated teleost retinas.
BURNSIDE, Beth, Dearry, A
core +4 more sources
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source