Results 61 to 70 of about 66,016 (272)

Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial

, 2014
Background: Choroideremia is an X-linked recessive disease that leads to blindness due to mutations in the CHM gene, which encodes the Rab escort protein 1 (REP1).
During, MJ, Reed Clark, K., Maclaren, Robert, Tolmachova, Tanya, Black, G.C.M., Seabra, Miguel C., Cottriall, Charles L., Groppe, M, Tolmachova, T, Black, Graeme C M, MacLaren, RE, Groppe, Markus, During, M.J., Reed Clark, K, Webster, A.R., Lotery, AJ, Barnard, Alun, Cremers, FPM, Clark, KR, MacLaren, Robert E., Cottriall, C.L., Downes, SM, Webster, AR, Seabra, MC, Cremers, Frans P M, Seymour, Len, Black, GCM, Downes, S.M., Seymour, L, Cottriall, CL, Cremers, F.P.M., Black, G.C., Clark, K., Seabra, M.C., Cremers, F.P., Groppe, M., Barnard, A.R., Barnard, AR, During, Matthew J., Black, GC, Lotery, Andrew J., Downes, Susan M., Seymour, L., Webster, Andrew R., MacLaren, R.E., Downes, Susan, Cremers, FP, Tolmachova, T., Lotery, A.J., Barnard, Alun R.   +49 more
core   +1 more source

Advanced nanotherapeutics for combating ocular infections: Rational design, antimicrobial mechanisms, and therapeutic breakthroughs

BMEMat, EarlyView.
Nanomaterials revolutionize ocular infection treatment by enabling targeted drug delivery and enhanced antimicrobial efficacy against resistant pathogens. This review systematically explores their rational design, multimodal mechanisms, and translational potential for next‐generation anti‐infective therapies.
Yujia Liu, Xuetian Wen, Yue Tan, Rui Zeng, Yijuan Zhang, Tong Lin, Lan Gong, Zichao Luo   +7 more
wiley   +1 more source

Retinal pigment epithelium condition after laser and ultrasound phacofragmentation. Electron microscopy in experiment. Report 1

Офтальмохирургия, 2013
Purpose. To perform a comparative evaluation of a macular retinal pigment epithelium condition after laser and ultrasound phacofragmentations in experiment. Material and method.
S.Y. Kopayev, V.G. Kopayeva, S.A. Borsenok,, V.U. Alborova   +3 more
doaj  

Congenital simple hamartoma of the retinal pigment epithelium with depigmentation at the margin in an Indian female

, 2019
Objective: To report a case of congenital simple hamartoma of the retinal pigment epithelium (CSHRPE) with depigmentation at the margin.Method: Case report.Result: A 40-year-old Indian female was noted to have a small pigmented lesion with a ...
Vatwani, KK, Bandyopadhyay, G, Shekhar, H, Tripathy, K, Basu, K   +4 more
core   +1 more source

Fluorescein angiography compared to three-dimensional measurements by the retinal thickness analyzer in classic choroidal neovascularization [PDF]

, 2007
Purpose: To compare and correlate imaging of classic subfoveal choroidal neovascularization (CNV) with noninvasive 3-dimensional imaging by the retinal thickness analyzer (RTA) to conventional fluorescein angiography (FA).
Strauss, R. W., Rombold, F., Neubauer, A. S., Kampik, Anselm   +3 more
core   +1 more source

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

Near-infrared fundus autoflorescence imaging in solar retinopathy

GMS Ophthalmology Cases, 2017
Solar retinopathy is a rare clinical entity caused by photochemical damage to the retinal pigment epithelium layer and photoreceptors of the fovea. Here we describe a case of a 33-year-old female patient diagnosed by near-infrared fundus autofluorescence
Czepita, Maciej, Machalińska, Anna, Czepita, Damian   +2 more
doaj   +1 more source

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source

RETINAL PIGMENT EPITHELIUM CONDITION AFTER LASER AND ULTRASOUND PHACOFRAGMENTATION. ELECTRON MICROSCOPY IN EXPERIMENT. REPORT 1

Офтальмохирургия, 2015
Purpose. To perform a comparative evaluation of a macular retinal pigment epithelium condition after laser and ultrasound phacofragmentations in experiment.Material and method.
S. Y. Kopayev, V. G. Kopayeva, S. A. Borsenok, V. U. Alborova   +3 more
doaj  

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source