Results 51 to 60 of about 66,016 (272)

JAPANESE QUAIL (COTURNIX JAPONICA) AS A MODEL OF ACCELERATED AGING OF HUMAN RETINAL PROCESSES. REPORT 1. ASSESSMENT OF THE AGE RPE LIPOFUSCIN ACCUMULATION DEPENDING ON THE RETINAL AMOUNT OF OXYCAROTENOIDS

Офтальмохирургия, 2015
Purpose. Using the eyes of quails C. japonic as a model system to evaluate age-related accumulation of lipofuscin granules in the cells of the retinal pigment epithelium depending on the level of oxycarotenoids content in the retina and in the retinal ...
P. P. Zak, A. V. Zykova, N. N. Trofimova, M. A. Ostrovsky   +3 more
doaj  

Clinicopathological correlation of parapapillary atrophy in monkeys with experimental glaucoma and temporary central retinal artery occlusion

Indian Journal of Ophthalmology, 2014
Objective: To investigate the clinicopathological correlation of parapapillary atrophy. Materials and Methods: The study included 16 eyes of rhesus monkeys (Macaca mulatta) - 4 eyes with experimental glaucoma, 11 eyes after experimental temporary ...
Jost B Jonas, Sohan S Hayreh, Yong Tao
doaj   +1 more source

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source

Japanese quail (Coturnix japonica) as a model of accelerated aging of human retinal processes. Report 1. Assessment of the age RPE lipofuscin accumulation depending on the retinal amount of oxycarotenoids

Офтальмохирургия, 2013
Purpose. Using the eyes of quails C. japonic as a model system to evaluate age-related accumulation of lipofuscin granules in the cells of the retinal pigment epithelium depending on the level of oxycarotenoids content in the retina and in the retinal ...
P.P. Zak, A.V. Zykova, N.N. Trofimova, M.A. Ostrovsky   +3 more
doaj  

Metabolic Deregulation of the Blood-Outer Retinal Barrier in Retinitis Pigmentosa

Cell Reports, 2019
Summary: Retinitis pigmentosa (RP) initiates with diminished rod photoreceptor function, causing peripheral and night-time vision loss. However, subsequent loss of cone function and high-resolution daylight and color vision is most debilitating.
Wei Wang, Ashwini Kini, Yekai Wang, Tingting Liu, Yao Chen, Eric Vukmanic, Douglas Emery, Yongqing Liu, Xiaoqin Lu, Lei Jin, San Joon Lee, Patrick Scott, Xiao Liu, Kevin Dean, Qingxian Lu, Enzo Fortuny, Robert James, Henry J. Kaplan, Jianhai Du, Douglas C. Dean   +19 more
doaj   +1 more source

Machine Learning Models of Phase Contrast Images Predict Efficiency of Human Pluripotent Stem Cell Differentiation to Cardiomyocytes

Biotechnology and Bioengineering, EarlyView.
Human pluripotent stem cells were differentiated to cTnT+ cardiomyocytes and imaged throughout the process using phase contrast. We predicted differentiation efficiency (cTnT+ area) from phase contrast and compared model performance with a live‐cell cTnT‐GFP reporter.
Austin K. Feeney, Yaniv Ovadia, Aaron D. Simmons, Christian Elabd, Claire J. Peplinski, Frank Li, Sean P. Palecek   +6 more
wiley   +1 more source

Detection of Retinal Pigment Epithelium-Specific Antibody in iPSC-Derived Retinal Pigment Epithelium Transplantation Models

Stem Cell Reports, 2017
Summary: Antibody-mediated rejection is characterized by donor-specific antibody produced by B cells. However, to our knowledge, B cell invasion and antibody in the inflamed retina after transplantation of retinal pigment epithelial (RPE) cells has not ...
Sunao Sugita, Kenichi Makabe, Shota Fujii, Yuko Iwasaki, Hiroyuki Kamao, Takashi Shiina, Kazumasa Ogasawara, Masayo Takahashi   +7 more
doaj   +1 more source

Osteopontin and fibronectin levels are decreased in vitreous of autoimmune uveitis and retinal expression of both proteins indicates ECM re-modeling. [PDF]

, 2011
Autoimmune uveitis is an intraocular inflammation that arises through autoreactive T-cells attacking the inner eye, eventually leading to blindness. However, the contributing molecular pathomechanisms within the affected tissues remain as yet elusive ...
Cornelia A. Deeg, Amann, B., Amann, Barbara, Hofmaier, F., Eberhardt Christina, Hauck Stefanie M., Barbara Amann, Hofmaier Florian, Christina Eberhardt, Florian Hofmaier, Eberhardt, Christina, Hauck, S.M., Cornelia A Deeg, Deeg Cornelia A., Amann Barbara, Stefanie M Hauck, Stefanie M. Hauck, Deeg, Cornelia A., Hauck, Stefanie M., Eberhardt, C., Hofmaier, Florian, Deeg, C.A.   +21 more
core   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Single-cell transcriptome of the mouse retinal pigment epithelium in response to a low-dose of doxorubicin

Communications Biology, 2022
Single cell transcriptomics pinpoints a cell subpopulation that could be involved in inducing cellular senescence of the retinal pigment epithelium, which in turn may construe retinal degenerative disease.
Hyungwoo Lee, Ho-Yeon Lee, Jae-Byoung Chae, Chul-Woo Park, Chaekyu Kim, Ja-Hyoung Ryu, Jiwon Jang, Namshin Kim, Hyewon Chung   +8 more
doaj   +1 more source