Results 81 to 90 of about 66,016 (272)

OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IMAGING OF A CONGENITAL SIMPLE HAMARTOMA OF THE RETINAL PIGMENT EPITHELIUM

, 2021
To report the case of a small pigmented tumor in the macular region investigated using optical coherence tomography angiography (OCT-A) in the context of a multimodal approach. Case report. A 24-year-old man was referred for evaluation of an asymptomatic
Leonidas Zografos, Ambresin, A., Zola, M., Zografos, L., Aude Ambresin, Marta Zola   +5 more
core   +1 more source

Beyond the Classics: The Synergy of AI and Genomics Reveals an Expanded Repertoire of Pigmentation Genes

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Classical approaches for coloration analysis are limited by human low‐resolution phenotyping and genetic analysis. Artificial intelligence allows us to find genes beyond the tip of the iceberg that explain color and pattern diversity in nature. ABSTRACT Pigmentation has long served as a powerful system for exploring gene–trait relationships, yet much ...
Ehsan Pashay Ahi, Nidal Karagic
wiley   +1 more source

Preclinical Evaluation of a Cell-Based Gene Therapy Using the Sleeping Beauty Transposon System in Choroidal Neovascularization

Molecular Therapy: Methods & Clinical Development, 2019
Age-related macular degeneration (AMD) is a progressive retinal disorder characterized by imbalanced pro- and antiangiogenic signals. The aim of this study was to evaluate the effect of ex vivo cell-based gene therapy with stable expression of human ...
Maria Hernandez, Sergio Recalde, Laura Garcia-Garcia, Jaione Bezunartea, Csaba Miskey, Sandra Johnen, Sabine Diarra, Attila Sebe, Juan Roberto Rodriguez-Madoz, Severine Pouillot, Corinne Marie, Zsuzsanna Izsvák, Daniel Scherman, Martina Kropp, Felipe Prosper, Gabriele Thumann, Zoltán Ivics, Alfredo Garcia-Layana, Patricia Fernandez-Robredo   +18 more
doaj   +1 more source

Candidate gene study of macular response to supplemental lutein and zeaxanthin. [PDF]

, 2013
Supplementation with carotenoids is proposed to protect against age-related macular degeneration. There is, however, considerable variability in retinal macular pigment response, which may be due to underlying genetic variation. The purpose of this study
Liew, SH Melissa, Venturini, Cristina, Williams, Katherine; id_orcid, Beatty, Stephen, Hysi, Pirro G., Williams, Katie M., Gilbert, Clare E, Gilbert, Clare E., Hysi, Pirro G, Williams, Katie M, Nag, Abhishek, Hammond, Christopher J., Liew, S.H. Melissa, Yonova-Doing, Ekaterina, Hammond, Christopher J, Liew, S H Melissa   +15 more
core   +1 more source

Beyond Skin and Eyes: The Medical and Social Burden of Oculocutaneous Albinism in Africa: A Narrative Review

JEADV Clinical Practice, EarlyView.
ABSTRACT Oculocutaneous albinism (OCA) is a genetic disorder found worldwide, but its impact is particularly pronounced in the African continent. This results from both a higher prevalence and the persistent myths and superstitions surrounding the condition in many African communities.
Rebecca Donadoni, Niccolò Capurro, Alessandro Svizzero, Valeria Brazzelli   +3 more
wiley   +1 more source

Glycemic Control, Animal Protein Intake, and the Risk of Diabetic Retinopathy Progression Among Patients With Type 2 Diabetes

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Effective glycemic control and food consumption play crucial roles in modulating diabetic retinopathy (DR) progression. This observational longitudinal study explored the hemoglobin A1c (HbA1c) and dietary patterns and their associations with the risk and progression of DR among 369 individuals with type 2 diabetes.
Yu‐Ju Wu, Chih‐Cheng Hsu, Chih‐Yiu Tsai, Shang‐Jyh Hwang, Kun‐Der Lin, Pi‐Chen Lin, Ya‐Fang Huang, Chiao‐I Chang, Meng‐Chuan Huang   +8 more
wiley   +1 more source

Ex Vivo Evaluation of Poly(Solketal Acrylate) Nanoparticles for Intravitreal Drug Delivery to the Posterior Eye Segment

Macromolecular Rapid Communications, EarlyView.
Nile Red‐loaded poly(solketal acrylate) nanoparticles enable fluorescence tracking and exhibit nontoxic profiles in retinal cells. Enhanced cellular uptake and deep retinal penetration after intravitreal injection highlight their excellent potential for targeted ocular drug delivery to the posterior segment of the eye.
Yasaman Pourdakheli Hamedani, José Hurst, Malte Ritter, Philipp Weingarten, Julia Skokowa, Sven Schnichels, Friederike Adams   +6 more
wiley   +1 more source

Ultra-high resolution optical coherence tomography analysis of bull's eye maculopathy in chloroquine users

Revista Brasileira de Oftalmologia, 2014
Purpose: Register and compare anatomical changes, structural and quantitative found in optical coherence tomography Stratus and Topcon 3D in chronic users of chloroquine.
Celso Morita, Daniel Araujo Ferraz, Thais Zamudio Igami, Beatriz Sayuri Takahashi, Tiago Faria e Arantes, Walter Yukihiko Takahashi   +5 more
doaj   +1 more source

Optical coherence tomography and fundus autofluorescence findings in presumed congenital simple retinal pigment epithelium hamartoma

, 2017
Aim: Presumed congenital simple retinal pigment epithelium hamartoma is a rare benign lesion of the macula that mimics congenital hypertrophy of the retinal pigment epithelium (RPE) and combined hamartoma of the retina and the RPE; newer imaging ...
Baskaran, P, Shah, P, Shukla, D
core   +1 more source

Homogenous Cell Transplantation Trials in Parkinson's Disease: A Systematic Review and Meta‐Analysis

Movement Disorders Clinical Practice, EarlyView.
Abstract Background The transplantation of homogenous cells has emerged as an investigational strategy for Parkinson's disease (PD), offering an alternative to symptomatic treatment. Objective We performed a systematic review and meta‐analysis to assess its clinical efficacy and safety.
Nolan Reinisch, Athena Mancini, Adham Elsherbini, Jason Yuen, Andres Lozano   +4 more
wiley   +1 more source