Results 211 to 220 of about 24,391 (241)

E13.5 retinal progenitors induce mouse bone marrow mesenchymal stromal cells to differentiate into retinal progenitor-like cells

Cytotherapy, 2011
Retinal progenitor cells (RPC) are an excellent resource for retinal replacement therapy but usually unavailable. We attempted to induce bone marrow mesenchymal stromal cells (BMSC) into RPC.BMSC and embryonic day 13.5 (E13.5) RPC derived from wild-type or enhanced green fluorescence protein (EGFP) transgenic (Egfp(+/+)) mice were co-cultured in a ...
Xuerong, Sun, Mengfei, Chen, Juan, Li, Jing, Zhuang, Qianying, Gao, Xiufeng, Zhong, Bing, Huang, Weizhong, Zhang, Li, Huang, Jian, Ge   +9 more
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Influence of a retinal pigment epithelial cell factor(s) on rat retinal progenitor cells

Developmental Brain Research, 1996
Retinal development was studied by explant culture of retinas from embryonic and neonatal rats in response to medium conditioned (CM) by a transformed neonatal rat retinal pigment epithelial (tnrRPE) cell line. Retinal explants from embryonic days 16 and 18 and postnatal day 2 Long-Evans rats were cultured for over 3 weeks on a poly-D,L-ornithine ...
H J, Sheedlo, J E, Turner
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Cell-intrinsic regulators of proliferation in vertebrate retinal progenitors

Seminars in Cell & Developmental Biology, 2004
The proliferative expansion of retinal progenitor cells (RPCs) is a fundamental mechanism of growth during vertebrate retinal development. Over the past couple of years, significant progress has been made in identifying genes expressed in RPCs that are essential for their proliferation, and the molecular mechanisms are beginning to be resolved. In this
Edward M, Levine, Eric S, Green
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Growth kinetics and transplantation of human retinal progenitor cells

Experimental Eye Research, 2009
We studied the growth kinetics of human retinal progenitor cells (hRPCs) isolated from donor tissue of different gestational ages (G.A.), determined whether hRPCs can be differentiated into mature photoreceptors and assessed their ability to integrate with degenerating host retina upon transplantation.
Unber, Aftab, Caihui, Jiang, Budd, Tucker, Ji Yeon, Kim, Henry, Klassen, Erik, Miljan, John, Sinden, Michael, Young   +7 more
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Retinal Progenitor Cells, Differentiation, and Barriers to Cell Cycle Reentry

2010
Neurogenesis in the retina occurs via the coordination of proliferation, cell cycle exit and differentiation of retinal progenitor cells. Until recently, it was widely assumed that once a retinal progenitor cell produced a postmitotic neuron, there was no possibility for cell-cycle re-entry. However, recent studies have shown that mature differentiated
Denise M, Davis, Michael A, Dyer
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Effects of retinal pigment epithelial cell‐secreted factors on neonatal rat retinal explant progenitor cells

Journal of Neuroscience Research, 1996
This study demonstrates the effects of conditioned media from transformed neonatal rat retinal pigment epithelial cells (tnrRPE-CM) in a culture system consisting of neonatal rat retinal explants. For this study, retinal explants from postnatal day 2 (PN2) normal rats were cultured for over 3 weeks on a poly-D-L-ornithine-coated surface in RPE-CM only,
H J, Sheedlo, J E, Turner
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Characterization of early retinal progenitor microenvironment: Presence of activities selective for the differentiation of retinal ganglion cells and maintenance of progenitors

Experimental Eye Research, 2007
The maintenance and differentiation of retinal progenitors take place in the context of the microenvironment in which they reside at a given time during retinal histogenesis. To understand the nature of the microenvironment in the developing retina, we have examined the influence of activities present during the early stage of retinal histogenesis on ...
Ganapati V, Hegde, Jackson, James, Ani V, Das, Xing, Zhao, Sumitra, Bhattacharya, Iqbal, Ahmad   +5 more
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Loss of retinal progenitor cells leads to an increase in the retinal stem cell population in vivo

European Journal of Neuroscience, 2005
AbstractRetinal stem cells [with the potential to produce either neural retinal progenitors or retinal pigment epithelial (RPE) progenitors] exist in the mammalian eye throughout life, and indeed the greatest absolute increase in the stem population occurs postnatally.
Brenda L K, Coles, D Jonathan, Horsford, Roderick R, McInnes, Derek, van der Kooy   +3 more
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A Comparison of Neural Differentiation and Retinal Transplantation with Bone Marrow‐Derived Cells and Retinal Progenitor Cells

STEM CELLS, 2006
Retinal progenitor cells (RPCs) are immature precursors that can differentiate into retinal neurons, including photoreceptors. Recently, it has been reported that bone marrow-derived cells may also be capable of differentiation into cells of central nervous system lineage, including retinal neurons.
Minoru, Tomita, Taisuke, Mori, Kazuichi, Maruyama, Tasneem, Zahir, Matthew, Ward, Akihiro, Umezawa, Michael J, Young   +6 more
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Progenitor Cell Transplantation for Retinal Disease

2008
Diseases of the retina frequently result in permanent visual impairment. One strategy for recovering lost function is to replace retinal neurons lost to the disease process, while another is to protect these neurons from dying in the first place. Retinal progenitor cell transplantation is an experimental approach that has relevance to both strategies ...
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