Results 1 to 10 of about 48,023 (234)

Retinal progenitor cells (jCell) for retinitis pigmentosa [PDF]

Frontiers in Cellular Neuroscience
ObjectiveTo assess the safety and tolerability of intravitreal injection of human retinal progenitor cells (RPCs) at multiple dose levels in adults with non-syndromic retinitis pigmentosa (RP).DesignA prospective, multicenter, open-label, single-arm ...
Jing Yang, Jing Yang, Baruch D. Kuppermann, David Liao, Mitul C. Mehta, Chinhui Hsiang, Chinhui Hsiang, Steven Menges, Steven Menges, David S. Boyer, Henry Klassen, Henry Klassen   +11 more
doaj   +5 more sources

Mesenchymal Stem Cells: Signaling Pathways in Transdifferentiation Into Retinal Progenitor Cells [PDF]

Basic and Clinical Neuroscience, 2021
Several signaling pathways and transcription factors control the cell fate in its in vitro development and differentiation. The orchestrated use of these factors results in cell specification. In coculture methods, many of these factors secrete from host
Hamid Aboutaleb Kadkhodaeian
doaj   +5 more sources

SURGICAL RETINAL EXPLANTS AS A SOURCE OF RETINAL PROGENITOR CELLS. [PDF]

Retina, 2021
Purpose: To describe the novel observation of spontaneously migrating retinal cells from living donor surgical retinal explants that express progenitor cell markers in the absence of exogenous growth factors. Methods: Surgical retinal explants were harvested from 5 consecutive ...
Too LK, Shen W, Mammo Z, Osaadon P, Gillies MC, Simunovic MP.   +5 more
europepmc   +4 more sources

Efficacy and Safety of Human Retinal Progenitor Cells. [PDF]

Translational Vision Science & Technology, 2016
PURPOSE: We assessed the long-term efficacy and safety of human retinal progenitor cells (hRPC) using established rodent models. METHODS: Efficacy of hRPC was tested initially in Royal College of Surgeons (RCS) dystrophic rats immunosuppressed with ...
Brooke, G, Carter, D, Coffey, P, Haamedi, N, Patel, S, Semo, M, Sinden, J, Stevanato, L, Vugler, A, Young, M   +9 more
core   +9 more sources

Mesenchymal stem cell–derived small extracellular vesicles enhance the therapeutic effect of retinal progenitor cells in retinal degenerative disease rats [PDF]

Neural Regeneration Research
Our previous study demonstrated that combined transplantation of bone marrow mesenchymal stem cells and retinal progenitor cells in rats has therapeutic effects on retinal degeneration that are superior to transplantation of retinal progenitor cells ...
Chunge Ren, Min Chen, Bangqi Ren, Yuxiao Zeng, Qiang Tan, Qiyou Li, Xue Zhang, Yajie Fang, Yixiao Zhou, Weitao Zhang, Fang Chen, Baishijiao Bian, Yong Liu   +12 more
doaj   +2 more sources

Cell Fate of Retinal Progenitor Cells: In Ovo UbC-StarTrack Analysis. [PDF]

Int J Mol Sci, 2022
Clonal cell analysis outlines the ontogenic potential of single progenitor cells, allowing the elucidation of the neural heterogeneity among different cell types and their lineages. In this work, we analyze the potency of retinal stem/progenitor cells through development using the chick embryo as a model.
Olmos-Carreño CL, Figueres-Oñate M, Scicolone GE, López-Mascaraque L.   +3 more
europepmc   +5 more sources

Six3 and Six6 jointly control diverse target genes in multiple cell populations over developmental trajectories of mouse embryonic retinal progenitor cells. [PDF]

PLoS ONE
How tissue-specific progenitor cells generate adult tissues is a puzzle in organogenesis. Using single-cell RNA sequencing of control and Six3 and Six6 compound-mutant mouse embryonic eyecups, we demonstrated that these two closely related transcription ...
Alexander Ferrena, Xusheng Zhang, Rupendra Shrestha, Deyou Zheng, Wei Liu   +4 more
doaj   +2 more sources

Single-cell analyses reveal transient retinal progenitor cells in the ciliary margin of developing human retina [PDF]

Nature Communications
The emergence of retinal progenitor cells and differentiation to various retinal cell types represent fundamental processes during retinal development.
Birthe Dorgau, Joseph Collin, Agata Rozanska, Darin Zerti, Adrienne Unsworth, Moira Crosier, Rafiqul Hussain, Jonathan Coxhead, Tamil Dhanaseelan, Aara Patel, Jane C. Sowden, David R. FitzPatrick, Rachel Queen, Majlinda Lako   +13 more
doaj   +2 more sources

Characterization of Progenitor Cells during Canine Retinal Development [PDF]

Stem Cells International, 2012
We identify the presence of progenitor cells during retinal development in the dog, as this species represents a natural model for studying several breed-specific degenerative retinal disorders.
Mallely Ávila-García, Gustavo García-Sánchez, Esmeralda Lira-Romero, Norma Moreno-Mendoza   +3 more
doaj   +3 more sources

Top2b regulates morphological and migratory properties of retinal progenitor cells in vivo and upon transplantable matrix substrates [PDF]

Exploration of BioMat-X
Aim: This study evaluated the impact of retinal extracellular matrix (ECM) and key biomaterial substrates on the motility of transplantable retinal cells with genomic manipulation, using the therapeutic molecule, Topoisomerase II beta (Top2b), as a model.
Alexandra C. Dabrowski, Alexandria R. Logan, Rameshwari Rayaji, Brianna Rodriguez, Li Cai, Maribel Vazquez   +5 more
doaj   +2 more sources