Results 1 to 10 of about 4,562,862 (262)

Retinal progenitor cells (jCell) for retinitis pigmentosa [PDF]

Frontiers in Cellular Neuroscience
ObjectiveTo assess the safety and tolerability of intravitreal injection of human retinal progenitor cells (RPCs) at multiple dose levels in adults with non-syndromic retinitis pigmentosa (RP).DesignA prospective, multicenter, open-label, single-arm ...
Jing Yang, Jing Yang, Baruch D. Kuppermann, David Liao, Mitul C. Mehta, Chinhui Hsiang, Chinhui Hsiang, Steven Menges, Steven Menges, David S. Boyer, Henry Klassen, Henry Klassen   +11 more
doaj   +5 more sources

Mesenchymal stem cell–derived small extracellular vesicles enhance the therapeutic effect of retinal progenitor cells in retinal degenerative disease rats [PDF]

Neural Regeneration Research
Our previous study demonstrated that combined transplantation of bone marrow mesenchymal stem cells and retinal progenitor cells in rats has therapeutic effects on retinal degeneration that are superior to transplantation of retinal progenitor cells ...
Chunge Ren, Min Chen, Bangqi Ren, Yuxiao Zeng, Qiang Tan, Qiyou Li, Xue Zhang, Yajie Fang, Yixiao Zhou, Weitao Zhang, Fang Chen, Baishijiao Bian, Yong Liu   +12 more
doaj   +2 more sources

Six3 and Six6 jointly control diverse target genes in multiple cell populations over developmental trajectories of mouse embryonic retinal progenitor cells. [PDF]

PLoS ONE
How tissue-specific progenitor cells generate adult tissues is a puzzle in organogenesis. Using single-cell RNA sequencing of control and Six3 and Six6 compound-mutant mouse embryonic eyecups, we demonstrated that these two closely related transcription ...
Alexander Ferrena, Xusheng Zhang, Rupendra Shrestha, Deyou Zheng, Wei Liu   +4 more
doaj   +2 more sources

Mesenchymal Stem Cells: Signaling Pathways in Transdifferentiation Into Retinal Progenitor Cells [PDF]

Basic and Clinical Neuroscience, 2021
Several signaling pathways and transcription factors control the cell fate in its in vitro development and differentiation. The orchestrated use of these factors results in cell specification. In coculture methods, many of these factors secrete from host
Hamid Aboutaleb Kadkhodaeian
doaj   +2 more sources

Single-cell analyses reveal transient retinal progenitor cells in the ciliary margin of developing human retina [PDF]

Nature Communications
The emergence of retinal progenitor cells and differentiation to various retinal cell types represent fundamental processes during retinal development.
Birthe Dorgau, Joseph Collin, Agata Rozanska, Darin Zerti, Adrienne Unsworth, Moira Crosier, Rafiqul Hussain, Jonathan Coxhead, Tamil Dhanaseelan, Aara Patel, Jane C. Sowden, David R. FitzPatrick, Rachel Queen, Majlinda Lako   +13 more
doaj   +2 more sources

Top2b regulates morphological and migratory properties of retinal progenitor cells in vivo and upon transplantable matrix substrates [PDF]

Exploration of BioMat-X
Aim: This study evaluated the impact of retinal extracellular matrix (ECM) and key biomaterial substrates on the motility of transplantable retinal cells with genomic manipulation, using the therapeutic molecule, Topoisomerase II beta (Top2b), as a model.
Alexandra C. Dabrowski, Alexandria R. Logan, Rameshwari Rayaji, Brianna Rodriguez, Li Cai, Maribel Vazquez   +5 more
doaj   +2 more sources

Stimulation of C-Kit+ Retinal Progenitor Cells by Stem Cell Factor Confers Protection Against Retinal Degeneration [PDF]

Frontiers in Pharmacology, 2022
C-kit/CD117, expressed in a series of tissue-specific progenitor cells, plays an important role in tissue regeneration and tissue homeostasis. We previously demonstrated that organoid-derived c-kit+ retinal progenitor cells can facilitate the restoration
Xi Chen, Shanshan Li, Xiaoli Liu, Jingjie Zhao, Lanting Wu, Ran You, Yanling Wang   +6 more
doaj   +2 more sources

Synaptic repair and vision restoration in advanced degenerating eyes by transplantation of retinal progenitor cells. [PDF]

Stem Cell Reports, 2021
He XY, Zhao CJ, Xu H, Chen K, Bian BS, Gong Y, Weng CH, Zeng YX, Fu Y, Liu Y, Yin ZQ.   +10 more
europepmc   +2 more sources

miR-762 regulates the proliferation and differentiation of retinal progenitor cells by targeting NPDC1. [PDF]

Cell Cycle, 2020
Gao H, Ni N, Zhang D, Wang Y, Tang Z, Sun N, Ju Y, Dai X, Zhang Y, Liu Y, Gu P.   +10 more
europepmc   +2 more sources

Novel Technique for Retinal Nerve Cell Regeneration with Electrophysiological Functions Using Human Iris-Derived iPS Cells

Cells, 2021
Regenerative medicine in ophthalmology that uses induced pluripotent stem cells (iPS) cells has been described, but those studies used iPS cells derived from fibroblasts.
Naoki Yamamoto, Noriko Hiramatsu, Mahito Ohkuma, Natsuko Hatsusaka, Shun Takeda, Noriaki Nagai, Ei-ichi Miyachi, Masashi Kondo, Kazuyoshi Imaizumi, Masayuki Horiguchi, Eri Kubo, Hiroshi Sasaki   +11 more
doaj   +1 more source