Single-cell analyses reveal transient retinal progenitor cells in the ciliary margin of developing human retina [PDF]
Nature CommunicationsThe emergence of retinal progenitor cells and differentiation to various retinal cell types represent fundamental processes during retinal development.
Birthe Dorgau +13 more
doaj +6 more sources
Individual retinal progenitor cells display extensive heterogeneity of gene expression. [PDF]
PLoS ONE, 2008 The development of complex tissues requires that mitotic progenitor cells integrate information from the environment. The highly varied outcomes of such integration processes undoubtedly depend at least in part upon variations among the gene expression ...
Jeffrey M Trimarchi +2 more
doaj +6 more sources
Adult limbal neurosphere cells: a potential autologous cell resource for retinal cell generation.
PLoS ONE, 2014 The Corneal limbus is a readily accessible region at the front of the eye, separating the cornea and sclera. Neural colonies (neurospheres) can be generated from adult corneal limbus in vitro.
Xiaoli Chen +5 more
doaj +2 more sources
Mesenchymal stem cell–derived small extracellular vesicles enhance the therapeutic effect of retinal progenitor cells in retinal degenerative disease rats [PDF]
Neural Regeneration ResearchOur previous study demonstrated that combined transplantation of bone marrow mesenchymal stem cells and retinal progenitor cells in rats has therapeutic effects on retinal degeneration that are superior to transplantation of retinal progenitor cells ...
Chunge Ren +12 more
doaj +2 more sources
Six3 and Six6 jointly control diverse target genes in multiple cell populations over developmental trajectories of mouse embryonic retinal progenitor cells. [PDF]
PLoS ONEHow tissue-specific progenitor cells generate adult tissues is a puzzle in organogenesis. Using single-cell RNA sequencing of control and Six3 and Six6 compound-mutant mouse embryonic eyecups, we demonstrated that these two closely related transcription ...
Alexander Ferrena +4 more
doaj +2 more sources
BMC Research Notes, 2012 Background Retinal progenitor cells are a convenient source of cell replacement therapy in retinal degenerative disorders. The purpose of this study was to evaluate the expression patterns of the homeobox genes PAX6 and CHX10 (retinal progenitor markers)
Sanie-Jahromi Fatemeh +9 more
doaj +2 more sources
Mesenchymal Stem Cells: Signaling Pathways in Transdifferentiation Into Retinal Progenitor Cells [PDF]
Basic and Clinical Neuroscience, 2021 Several signaling pathways and transcription factors control the cell fate in its in vitro development and differentiation. The orchestrated use of these factors results in cell specification. In coculture methods, many of these factors secrete from host
Hamid Aboutaleb Kadkhodaeian
doaj +2 more sources
Cell Transplantation, 2010 Human fetal retinal cells have been widely advocated for the development of cellular replacement therapies in patients with retinal dystrophies and age-related macular degeneration.
Shazeen M. Hasan +5 more
doaj +2 more sources
Top2b regulates morphological and migratory properties of retinal progenitor cells in vivo and upon transplantable matrix substrates [PDF]
Exploration of BioMat-XAim: This study evaluated the impact of retinal extracellular matrix (ECM) and key biomaterial substrates on the motility of transplantable retinal cells with genomic manipulation, using the therapeutic molecule, Topoisomerase II beta (Top2b), as a model.
Alexandra C. Dabrowski +5 more
doaj +2 more sources
Stimulation of C-Kit+ Retinal Progenitor Cells by Stem Cell Factor Confers Protection Against Retinal Degeneration [PDF]
Frontiers in Pharmacology, 2022 C-kit/CD117, expressed in a series of tissue-specific progenitor cells, plays an important role in tissue regeneration and tissue homeostasis. We previously demonstrated that organoid-derived c-kit+ retinal progenitor cells can facilitate the restoration
Xi Chen +6 more
doaj +2 more sources