The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina
Summary: Notch signaling in neural progenitor cell is triggered by ligands expressed in adjacent cells. To identify the sources of active Notch ligands in the mouse retina, we negatively regulated Notch ligand activity in various neighbors of retinal ...
Taejeong Ha +8 more
doaj +1 more source
Milieu-adopted in vitro and in vivo differentiation of mesenchymal tissues derived from different adult human CD34-negative progenitor cell clones [PDF]
Adult mesenchymal stem cells with multilineage differentiation potentially exist in the bone marrow, but have also been isolated from the peripheral blood.
Moser, C. +4 more
core +1 more source
Bipotent progenitors as embryonic origin of retinal stem cells [PDF]
In lower vertebrates, retinal stem cells (RSCs) capable of producing all retinal cell types are a resource for retinal tissue growth throughout life. However, the embryonic origin of RSCs remains largely elusive. Using a Zebrabow-based clonal analysis, we characterized the RSC niche in the ciliary marginal zone of zebrafish retina and illustrate that ...
Xia Tang +6 more
openaire +2 more sources
A multipotent transit-amplifying neuroblast lineage in the central brain gives rise to optic lobe glial cells in Drosophila [PDF]
The neurons and glial cells of the Drosophila brain are generated by neural stem cell-like progenitors during two developmental phases, one short embryonic phase and one more prolonged postembryonic phase.
Reichert, Heinrich +2 more
core +1 more source
Molecular Characterization of Human Retinal Progenitor Cells
To examine the molecular profile of fetal human retinal progenitor cells (hRPCs) expanded in vitro and those grown in a co-culture system with mouse retina through the analysis of protein and gene expression and neurotransmitter-stimulated calcium dynamics.hRPCS were isolated from human retina of 14 to 18 weeks gestational age (GA) and expanded in ...
Scott, Schmitt +7 more
openaire +2 more sources
The role of the host—Neutrophil biology
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Gap junctions modulate interkinetic nuclear movement in retinal progenitor cells
During early retinal development, progenitor cells must divide repeatedly to expand the progenitor pool. During G1 and G2 of the cell cycle, progenitor cell nuclei migrate back-and-forth across the proliferative zone in a process termed interkinetic ...
Lüneborg, N.L. +7 more
core +1 more source
Localisation of NG2 immunoreactive neuroglia cells in the rat locus coeruleus and their plasticity in response to stress [PDF]
The locus coeruleus (LC) nucleus modulates adaptive behavioural responses to stress and dysregulation of LC neuronal activity is implicated in stress-induced mental illnesses.
Metzger, Friedrich +22 more
core +1 more source
Embryonic cortical neural stem cells migrate ventrally and persist as postnatal striatal stem cells [PDF]
Embryonic cortical neural stem cells apparently have a transient existence, as they do not persist in the adult cortex. We sought to determine the fate of embryonic cortical stem cells by following Emx1(IREScre); LacZ/EGFP double-transgenic murine cells ...
Seaberg, R.M. +18 more
core +1 more source
Polo-Like Kinase 3 Appears Dispensable for Normal Retinal Development Despite Robust Embryonic Expression. [PDF]
During retinogenesis seven different cell types are generated in distinct yet overlapping timepoints from a population of retinal progenitor cells.
Jillian J Goetz +4 more
doaj +1 more source

