Results 31 to 40 of about 24,696 (239)

Cell Replacement Therapy for Retinal and Optic Nerve Diseases: Cell Sources, Clinical Trials and Challenges

Pharmaceutics, 2021
The aim of this review was to provide an update on the potential of cell therapies to restore or replace damaged and/or lost cells in retinal degenerative and optic nerve diseases, describing the available cell sources and the challenges involved in such
Rosa M. Coco-Martin, Salvador Pastor-Idoate, Jose Carlos Pastor   +2 more
doaj   +1 more source

A Disintegrin and Metalloproteinase10 (ADAM10) Regulates NOTCH Signaling during Early Retinal Development. [PDF]

PLoS ONE, 2016
ADAM10 and ADAM17 are two closely related members of the ADAM (a disintegrin and metalloprotease) family of membrane-bound sheddases, which proteolytically cleave surface membrane proteins.
Joseph A Toonen, Adam Ronchetti, D J Sidjanin   +2 more
doaj   +1 more source

Bifunctional MXene‐Augmented Retinal Progenitor Cell Transplantation for Retinal Degeneration

Advanced Science, 2023
AbstractRetinal degeneration, characterized by the progressive loss of retinal neurons, is the leading cause of incurable visual impairment. Retinal progenitor cells (RPCs)‐based transplantation can facilitate sight restoration, but the clinical efficacy of this process is compromised by the imprecise neurogenic differentiation of RPCs and undermining ...
Zhimin Tang, Yan Liu, Huijing Xiang, Xinyue Dai, Xiaolin Huang, Yahan Ju, Ni Ni, Rui Huang, Huiqin Gao, Jing Zhang, Xianqun Fan, Yun Su, Yu Chen, Ping Gu   +13 more
openaire   +3 more sources

Jarid2 promotes temporal progression of retinal progenitors via repression of Foxp1

Cell Reports, 2023
Summary: Transitions in competence underlie the ability of CNS progenitors to generate a diversity of neurons and glia. Retinal progenitor cells in mouse generate early-born cell types embryonically and late-born cell types largely postnatally.
Jianmin Zhang, Jacqueline M. Roberts, Fei Chang, Joon Schwakopf, Monica L. Vetter   +4 more
doaj   +1 more source

OTX2 represses sister cell fate choices in the developing retina to promote photoreceptor specification

eLife, 2020
During vertebrate retinal development, subsets of progenitor cells generate progeny in a non-stochastic manner, suggesting that these decisions are tightly regulated.
Miruna Georgiana Ghinia Tegla, Diego F Buenaventura, Diana Y Kim, Cassandra Thakurdin, Kevin C Gonzalez, Mark M Emerson   +5 more
doaj   +1 more source

Improved arteriogenesis with simultaneous skeletal muscle repair in ischemic tissue by SCL plus multipotent adult progenitor cell clones from peripheral blood [PDF]

, 2004
Background: The CD34- murine stem cell line RM26 cloned from peripheral blood mononuclear cells has been shown to generate hematopoietic progeny in lethally irradiated animals.
Seliger, Christian, Huss, Ralf, Kinston, Sarah, Gottgens, Berthold, Heil, Matthias, Sabine Moosmann, Matthias Heil, Christian Seliger, Sabine Sagebiel, Berthold Gottgens, Tibor Ziegelhoeffer, Moosmann, Sabine, Ralf Huss, Sarah Kinston, Ziegelhoeffer, Tibor, Sagebiel, Sabine   +15 more
core   +1 more source

TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia

CNS Neuroscience &Therapeutics, EarlyView., 2023
Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi, Decheng Ren, Fan Yuan, Zhou Zhang, Daizhan Zhou, Xin Yi, Lei Ji, Keyi Li, Fengping Yang, Xi Wu, Xingwang Li, Yifeng Xu, Yun Liu, Peng Wang, Changqun Cai, Chuanxin Liu, Qian Ma, Lin He, Yi Shi, Guang He   +19 more
wiley   +1 more source

Cultured subventricular zone progenitor cells transduced with neurogenin-2 become mature glutamatergic neurons and integrate into the dentate gyrus. [PDF]

, 2012
We have previously shown that transplantation of immature DCX+/NeuN+/Prox1+ neurons (found in the neonatal DG), but not undifferentiated neuronal progenitor cells (NPCs) from ventral subventricular zone (SVZ), results in neuronal maturation in vivo ...
Xia Chen, Lepier Alexandra, Tolkovsky Aviva M., Alexandra Lepier, Chen, Xia, Aviva M Tolkovsky, Lepier, Alexandra, Chen, X., Berninger, Benedikt, Herbert, Joe, Chen Xia, Herbert Joe, Lepier, A., Tolkovsky, A.M., Berninger Benedikt, Tolkovsky, Aviva M., Benedikt Berninger, Joe Herbert, Berninger, B., Herbert, J.   +19 more
core   +1 more source

Expression of SIRT1 and DBC1 in Developing and Adult Retinas

Stem Cells International, 2012
Sirtuin 1 (SIRT1) is a deacetylase that can regulate various biological processes via repression of transcription. Its activity has been linked to the differentiation of neural progenitor cells, although little is known about its function during retinal ...
Shawn C. Maloney, Emilia Antecka, Alexandre N. Odashiro, Bruno F. Fernandes, Madeline Doyle, Li-Anne Lim, Yousef Katib, Miguel N. Burnier   +7 more
doaj   +1 more source

Progress of stem/progenitor cell-based therapy for retinal degeneration

Journal of Translational Medicine, 2017
Retinal degeneration (RD), such as age-related macular degeneration (AMD) and retinitis pigmentosa, is one of the leading causes of blindness. Presently, no satisfactory therapeutic options are available for these diseases principally because the retina ...
Zhimin Tang, Yi Zhang, Yuyao Wang, Dandan Zhang, Bingqiao Shen, Min Luo, Ping Gu   +6 more
doaj   +1 more source