Results 31 to 40 of about 4,562,862 (262)

OTX2 represses sister cell fate choices in the developing retina to promote photoreceptor specification

eLife, 2020
During vertebrate retinal development, subsets of progenitor cells generate progeny in a non-stochastic manner, suggesting that these decisions are tightly regulated.
Miruna Georgiana Ghinia Tegla, Diego F Buenaventura, Diana Y Kim, Cassandra Thakurdin, Kevin C Gonzalez, Mark M Emerson   +5 more
doaj   +1 more source

Expression of SIRT1 and DBC1 in Developing and Adult Retinas

Stem Cells International, 2012
Sirtuin 1 (SIRT1) is a deacetylase that can regulate various biological processes via repression of transcription. Its activity has been linked to the differentiation of neural progenitor cells, although little is known about its function during retinal ...
Shawn C. Maloney, Emilia Antecka, Alexandre N. Odashiro, Bruno F. Fernandes, Madeline Doyle, Li-Anne Lim, Yousef Katib, Miguel N. Burnier   +7 more
doaj   +1 more source

Immortalized Human Fetal Retinal Cells Retain Progenitor Characteristics and Represent a Potential Source for the Treatment of Retinal Degenerative Disease

Cell Transplantation, 2010
Human fetal retinal cells have been widely advocated for the development of cellular replacement therapies in patients with retinal dystrophies and age-related macular degeneration.
Shazeen M. Hasan, Anthony A. Vugler, Erik A. Miljan, John D. Sinden, Stephen E. Moss, John Greenwood   +5 more
doaj   +1 more source

Progress of stem/progenitor cell-based therapy for retinal degeneration

Journal of Translational Medicine, 2017
Retinal degeneration (RD), such as age-related macular degeneration (AMD) and retinitis pigmentosa, is one of the leading causes of blindness. Presently, no satisfactory therapeutic options are available for these diseases principally because the retina ...
Zhimin Tang, Yi Zhang, Yuyao Wang, Dandan Zhang, Bingqiao Shen, Min Luo, Ping Gu   +6 more
doaj   +1 more source

Angiogenic potential of endothelial progenitor cells and embryonic stem cells [PDF]

, 2011
Background: Endothelial progenitor cells (EPCs) are implicated in a range of pathological conditions, suggesting a natural therapeutic role for EPCs in angiogenesis.
St John, Justin, Kelly, Richard, Kelly, RDW, Stuart Egginton, Rae, Peter, Richard DW Kelly, StJohn, JC, Peter C Rae, St. John, Justin C., Justin C St John, Rae, Peter C., Egginton, Stuart, Rae, PC, Egginton, S, Kelly, Richard D. W., St John, JC   +15 more
core   +1 more source

Improved arteriogenesis with simultaneous skeletal muscle repair in ischemic tissue by SCL plus multipotent adult progenitor cell clones from peripheral blood [PDF]

, 2004
Background: The CD34- murine stem cell line RM26 cloned from peripheral blood mononuclear cells has been shown to generate hematopoietic progeny in lethally irradiated animals.
Seliger, Christian, Huss, Ralf, Kinston, Sarah, Gottgens, Berthold, Heil, Matthias, Sabine Moosmann, Matthias Heil, Christian Seliger, Sabine Sagebiel, Berthold Gottgens, Tibor Ziegelhoeffer, Moosmann, Sabine, Ralf Huss, Sarah Kinston, Ziegelhoeffer, Tibor, Sagebiel, Sabine, Berthold Gottgensc, Tibor Ziegelhoefferb, Matthias Heilb, W Tissue, Sarah Kinstonc, Adult W Map-c, Sabine Sagebiela, Dr. Ralf Huss, Ralf Hussa, W Scl, Sabine Moosmanna, W Arteriogenesis, J Vasc Res, Christian Seligera   +29 more
core   +1 more source

Phenotypic characterization of regional human meniscus progenitor cells. [PDF]

, 2022
Stimulating meniscus regeneration using meniscal progenitor cells has been suggested as a promising new strategy. However, there is a lack of studies which decisively identify and characterize progenitor cell populations in human meniscus tissues.

core   +1 more source

The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina

Cell Reports, 2017
Summary: Notch signaling in neural progenitor cell is triggered by ligands expressed in adjacent cells. To identify the sources of active Notch ligands in the mouse retina, we negatively regulated Notch ligand activity in various neighbors of retinal ...
Taejeong Ha, Kyeong Hwan Moon, Le Dai, Jun Hatakeyama, Keejung Yoon, Hee-Sae Park, Young-Yoon Kong, Kenji Shimamura, Jin Woo Kim   +8 more
doaj   +1 more source

Efficacy and Safety of Human Retinal Progenitor Cells

Translational Vision Science & Technology, 2016
We assessed the long-term efficacy and safety of human retinal progenitor cells (hRPC) using established rodent models.Efficacy of hRPC was tested initially in Royal College of Surgeons (RCS) dystrophic rats immunosuppressed with cyclosporine/dexamethasone.
Semo, M, Haamedi, N, Stevanato, L, Carter, D, Brooke, G, Young, M, Coffey, P, Sinden, J, Patel, S, Vugler, A   +9 more
openaire   +3 more sources

Cultured subventricular zone progenitor cells transduced with neurogenin-2 become mature glutamatergic neurons and integrate into the dentate gyrus. [PDF]

, 2012
We have previously shown that transplantation of immature DCX+/NeuN+/Prox1+ neurons (found in the neonatal DG), but not undifferentiated neuronal progenitor cells (NPCs) from ventral subventricular zone (SVZ), results in neuronal maturation in vivo ...
Xia Chen, Lepier Alexandra, Tolkovsky Aviva M., Alexandra Lepier, Chen, Xia, Aviva M Tolkovsky, Lepier, Alexandra, Chen, X., Berninger, Benedikt, Herbert, Joe, Chen Xia, Herbert Joe, Lepier, A., Tolkovsky, A.M., Berninger Benedikt, Tolkovsky, Aviva M., Benedikt Berninger, Joe Herbert, Berninger, B., Herbert, J.   +19 more
core   +2 more sources