Bifunctional MXene‐Augmented Retinal Progenitor Cell Transplantation for Retinal Degeneration
Advanced Science, 2023 AbstractRetinal degeneration, characterized by the progressive loss of retinal neurons, is the leading cause of incurable visual impairment. Retinal progenitor cells (RPCs)‐based transplantation can facilitate sight restoration, but the clinical efficacy of this process is compromised by the imprecise neurogenic differentiation of RPCs and undermining ...
Zhimin Tang +13 more
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Human Retinal Progenitor Cell Transplantation Preserves Vision [PDF]
Journal of Biological Chemistry, 2014 Cell transplantation is a potential therapeutic strategy for retinal degenerative diseases involving the loss of photoreceptors. However, it faces challenges to clinical translation due to safety concerns and a limited supply of cells. Human retinal progenitor cells (hRPCs) from fetal neural retina are expandable in vitro and maintain an ...
Jing, Luo +21 more
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Stimulation of C-Kit+ Retinal Progenitor Cells by Stem Cell Factor Confers Protection Against Retinal Degeneration [PDF]
Frontiers in Pharmacology, 2022 C-kit/CD117, expressed in a series of tissue-specific progenitor cells, plays an important role in tissue regeneration and tissue homeostasis. We previously demonstrated that organoid-derived c-kit+ retinal progenitor cells can facilitate the restoration
Xi Chen +6 more
doaj +2 more sources
A microfabricated scaffold for retinal progenitor cell grafting [PDF]
Biomaterials, 2008 Diseases that cause photoreceptor cell degeneration afflict millions of people, yet no restorative treatment exists for these blinding disorders. Replacement of photoreceptors using retinal progenitor cells (RPCs) represents a promising therapy for the treatment of retinal degeneration.
William L, Neeley +6 more
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Individual retinal progenitor cells display extensive heterogeneity of gene expression. [PDF]
PLoS ONE, 2008 The development of complex tissues requires that mitotic progenitor cells integrate information from the environment. The highly varied outcomes of such integration processes undoubtedly depend at least in part upon variations among the gene expression ...
Jeffrey M Trimarchi +2 more
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CD133+ adult human retinal cells remain undifferentiated in Leukaemia Inhibitory Factor (LIF) [PDF]
BMC Ophthalmology, 2009 Background CD133 is a cell surface marker of haematopoietic stem and progenitor cells. Leukaemia inhibitory factor (LIF), sustains proliferation and not differentiation of embryonic stem cells.
Mayer Eric J +2 more
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Interphotoreceptor matrix-poly(ϵ-caprolactone) composite scaffolds for human photoreceptor differentiation [PDF]
Journal of Tissue Engineering, 2014 Tissue engineering has been widely applied in different areas of regenerative medicine, including retinal regeneration. Typically, artificial biopolymers require additional surface modification (e.g. with arginine–glycine–aspartate-containing peptides or
Petr Baranov +4 more
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Intravitreal Injection of Human Retinal Progenitor Cells for Treatment of Retinal Degeneration. [PDF]
Med Sci Monit, 2020 BACKGROUND Retinal degeneration causes irreversible blindness. Human retinal progenitor cells (hRPCs) have the potential to treat retinal diseases. The vitreous cavity is a relatively immune-privileged site that is suitable for stem cell transplantation in the treatment of retinal diseases.
Wang Z +7 more
europepmc +4 more sources
Reduced mTORC1-signalling in retinal progenitor cells leads to visual pathway dysfunction [PDF]
Biology Open, 2019 Development of the vertebrate central nervous system involves the co-ordinated differentiation of progenitor cells and the establishment of functional neural networks.
Iwan Jones +2 more
doaj +2 more sources
Scientific Reports, 2021 Notch signaling is required to repress the formation of vertebrate cone photoreceptors and to maintain the proliferative potential of multipotent retinal progenitor cells.
Xueqing Chen, Mark M. Emerson
doaj +1 more source