Cells, 2021 Regenerative medicine in ophthalmology that uses induced pluripotent stem cells (iPS) cells has been described, but those studies used iPS cells derived from fibroblasts.
Naoki Yamamoto +11 more
doaj +1 more source
Morphological asymmetry in dividing retinal progenitor cells [PDF]
Development, Growth & Differentiation, 2003 For the understanding of histogenetic events in the 3‐D retinal neuroepithelium, direct observation of the progenitor cells and their morphological changes is required. A slice culture method has been developed by which the behavior of single progenitor cells can be monitored.
Kanako, Saito +5 more
openaire +2 more sources
Influence of hypoxia on retinal progenitor and ganglion cells in human induced pluripotent stem cell-derived retinal organoids [PDF]
International Journal of Ophthalmology, 2023 AIM: To observe the effect of low oxygen concentration on the neural retina in human induced pluripotent stem cell (hiPSC)-derived retinal organoids (ROs). METHODS: The hiPSC and a three-dimensional culture method were used for the experiments. Generated
Jin-Lin Du +9 more
doaj +1 more source
Stem Cell Research & Therapy, 2021 Objective Retinal degenerative diseases remain the dominant causes of blindness worldwide, and cell replacement is viewed as a promising therapeutic direction. However, the resources of seed cells are hard to obtain.
Yifeng Ke +8 more
doaj +1 more source
Pharmaceutics, 2021 The aim of this review was to provide an update on the potential of cell therapies to restore or replace damaged and/or lost cells in retinal degenerative and optic nerve diseases, describing the available cell sources and the challenges involved in such
Rosa M. Coco-Martin +2 more
doaj +1 more source
A Disintegrin and Metalloproteinase10 (ADAM10) Regulates NOTCH Signaling during Early Retinal Development. [PDF]
PLoS ONE, 2016 ADAM10 and ADAM17 are two closely related members of the ADAM (a disintegrin and metalloprotease) family of membrane-bound sheddases, which proteolytically cleave surface membrane proteins.
Joseph A Toonen +2 more
doaj +1 more source
Bio-inspired chiral self-assemblies promoted neuronal differentiation of retinal progenitor cells through activation of metabolic pathway. [PDF]
Bioact Mater, 2021 Sun N +12 more
europepmc +2 more sources
Elevated expression of human bHLH factor ATOH7 accelerates cell cycle progression of progenitors and enhances production of avian retinal ganglion cells. [PDF]
, 2018 The production of vertebrate retinal projection neurons, retinal ganglion cells (RGCs), is regulated by cell-intrinsic determinants and cell-to-cell signaling events.
Hashimoto, Takao +3 more
core +1 more source
Activation of c-Jun N-terminal kinase (JNK) during mitosis in retinal progenitor cells. [PDF]
PLoS ONE, 2012 Most studies of c-Jun N-terminal Kinase (JNK) activation in retinal tissue were done in the context of neurodegeneration. In this study, we investigated the behavior of JNK during mitosis of progenitor cells in the retina of newborn rats.
Vinicius Toledo Ribas +3 more
doaj +1 more source
Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light responsiveness of human pluripotent stem cell derived retinal organoids [PDF]
, 2019 Tissue specific extracellular matrices (ECM) provide structural support and enable access to molecular signals and metabolites, which are essential for directing stem cell renewal and differentiation.
Al-Aama, Jumana +15 more
core +2 more sources