Results 21 to 30 of about 4,562,862 (262)
Stem Cell Research & Therapy, 2021 Objective Retinal degenerative diseases remain the dominant causes of blindness worldwide, and cell replacement is viewed as a promising therapeutic direction. However, the resources of seed cells are hard to obtain.
Yifeng Ke +8 more
doaj +1 more source
A microfabricated scaffold for retinal progenitor cell grafting [PDF]
Biomaterials, 2008 Diseases that cause photoreceptor cell degeneration afflict millions of people, yet no restorative treatment exists for these blinding disorders. Replacement of photoreceptors using retinal progenitor cells (RPCs) represents a promising therapy for the treatment of retinal degeneration.
William L, Neeley +6 more
openaire +2 more sources
Pharmaceutics, 2021 The aim of this review was to provide an update on the potential of cell therapies to restore or replace damaged and/or lost cells in retinal degenerative and optic nerve diseases, describing the available cell sources and the challenges involved in such
Rosa M. Coco-Martin +2 more
doaj +1 more source
Intravitreal Injection of Human Retinal Progenitor Cells for Treatment of Retinal Degeneration. [PDF]
Med Sci Monit, 2020 BACKGROUND Retinal degeneration causes irreversible blindness. Human retinal progenitor cells (hRPCs) have the potential to treat retinal diseases. The vitreous cavity is a relatively immune-privileged site that is suitable for stem cell transplantation in the treatment of retinal diseases.
Wang Z +7 more
europepmc +4 more sources
Dual requirement for Pax6 in retinal progenitor cells [PDF]
Development, 2008 Throughout the developing central nervous system, pre-patterning of the ventricular zone into discrete neural progenitor domains is one of the predominant strategies used to produce neuronal diversity in a spatially coordinated manner. In the retina, neurogenesis proceeds in an intricate chronological and spatial sequence, yet it remains unclear ...
Oron-Karni, Varda +8 more
openaire +3 more sources
A Disintegrin and Metalloproteinase10 (ADAM10) Regulates NOTCH Signaling during Early Retinal Development. [PDF]
PLoS ONE, 2016 ADAM10 and ADAM17 are two closely related members of the ADAM (a disintegrin and metalloprotease) family of membrane-bound sheddases, which proteolytically cleave surface membrane proteins.
Joseph A Toonen +2 more
doaj +1 more source
Gap junctions modulate interkinetic nuclear movement in retinal progenitor cells [PDF]
, 2005 During early retinal development, progenitor cells must divide repeatedly to expand the progenitor pool. During G1 and G2 of the cell cycle, progenitor cell nuclei migrate back-and-forth across the proliferative zone in a process termed interkinetic ...
Lüneborg, N.L. +7 more
core +1 more source
Activation of c-Jun N-terminal kinase (JNK) during mitosis in retinal progenitor cells. [PDF]
PLoS ONE, 2012 Most studies of c-Jun N-terminal Kinase (JNK) activation in retinal tissue were done in the context of neurodegeneration. In this study, we investigated the behavior of JNK during mitosis of progenitor cells in the retina of newborn rats.
Vinicius Toledo Ribas +3 more
doaj +1 more source
Jarid2 promotes temporal progression of retinal progenitors via repression of Foxp1
Cell Reports, 2023 Summary: Transitions in competence underlie the ability of CNS progenitors to generate a diversity of neurons and glia. Retinal progenitor cells in mouse generate early-born cell types embryonically and late-born cell types largely postnatally.
Jianmin Zhang +4 more
doaj +1 more source
Purinergic and muscarinic modulation of the cell cycle and calcium signaling in the chick retinal ventricular zone [PDF]
, 2002 Spontaneous calcium transients occur in the ventricular zone of the chick retina and result from the endogenous release of neurotransmitters in the absence of action potentials.
Catsicas, M. +15 more
core +1 more source