Results 201 to 210 of about 614,351 (314)

Discovery of a First‐in‐Class Dual‐Function TLX Activator by Microscale Library Synthesis and Direct‐to‐Biology Screening

open access: yesAngewandte Chemie Novit, Volume 2, Issue 4, December 2026.
The transcription factor tailless (TLX) is an orphan nuclear receptor thought to maintain neural and retinal stem cell populations in a proliferating state to enable regeneration. Ligands to study TLX modulation were lacking. We developed a potent TLX agonist capable of activating TLX's transcriptional repressor and activator properties in an evolution‐
Tanja Stiller   +12 more
wiley   +1 more source

A Müller Glia‐Retinal Pigment Epithelium Apical Network Surrounding Cone Outer Segments in Fish and Mouse

open access: yesGlia, Volume 74, Issue 12, December 2026.
Müller glia and the retinal pigment epithelium interact around cone outer segment in the subretinal space of both zebrafish and mouse. The contacts are established early during development but subsequent to outer segment emergence. ABSTRACT Homeostasis of the vertebrate retina critically depends on two non‐neuronal cell populations, Müller glia and the
Maria Sharkova   +6 more
wiley   +1 more source

Reawakening the lost regenerative power of Müller glia: Epigenetic locks and immune gates in retinal repair

open access: hybrid
Marília Inês Móvio   +3 more
openalex   +1 more source

Biphasic Role of Tgf-β Signaling during Müller Glia Reprogramming and Retinal Regeneration in Zebrafish. [PDF]

open access: yesiScience, 2020
Sharma P   +7 more
europepmc   +1 more source

Structural and biochemical basis for retinol‐binding protein 4 antagonism by tinlarebant

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 23, Page 6737-6748, December 2026.
Background and Purpose Retinol‐binding protein 4 (RBP4) is a member of the lipocalin superfamily that is connected to disease states such as insulin resistance, fatty liver disease and ocular disorders including Stargardt disease. Several retinoid and non‐retinoid antagonists of this protein have been developed for potential clinical use, but none have
Marco Bassetto, Philip D. Kiser
wiley   +1 more source

Neuroprotective Properties of Photobiomodulation in Retinal Regeneration in Rats: Perspectives From Interaction Levels. [PDF]

open access: yesJ Lasers Med Sci, 2020
Mansouri V   +9 more
europepmc   +1 more source

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