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The Retinal Pigment Epithelium: An Important Player of Retinal Disorders and Regeneration
Experimental Eye Research, 2014The retinal pigment epithelium (RPE) is a partner of the neural retina and is indispensable for vision. In humans, proliferation and transformation (cell-type switching) of RPE cells after a traumatic injury of the neural retina causes a retinal disorder leading to loss of vision.
Chikafumi Chiba
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Developmental Neurobiology, 2014
ABSTRACTOur research group has extensively studied retinal regeneration in adultXenopus laevis. However,X. laevisdoes not represent a suitable model for multigenerational genetics and genomic approaches. Instead,Xenopus tropicalisis considered as the ideal model for these studies, although little is known about retinal regeneration inX. tropicalis.
Masasuke Araki
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ABSTRACTOur research group has extensively studied retinal regeneration in adultXenopus laevis. However,X. laevisdoes not represent a suitable model for multigenerational genetics and genomic approaches. Instead,Xenopus tropicalisis considered as the ideal model for these studies, although little is known about retinal regeneration inX. tropicalis.
Masasuke Araki
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Müller Stem Cell Dependent Retinal Regeneration
Clinica Chimica Acta, 2017Müller Stem cells to treat ocular diseases has triggered enthusiasm across all medical and scientific communities. Recent development in the field of stem cells has widened the prospects of applying cell based therapies to regenerate ocular tissues that have been irreversibly damaged by disease or injury.
Usha Singh
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Dynamic Functional and Structural Remodeling During Retinal Regeneration in Zebrafish [PDF]
Frontiers in Molecular Neuroscience, 2022 Deborah L Stenkamp +2 more
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Epigenetic Mechanisms of Müller Glial Reprogramming Mediating Retinal Regeneration [PDF]
Frontiers in Cell and Developmental Biology, 2023 Weidong Zang, Songxue Su
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Seminars in Ophthalmology, 2005
We discuss the potential use of stem cells for therapeutic angiogenesis in the treatment of retinal diseases. We demonstrate that the clinical utility of these EPC may be not limited in the treatment of ischemic retinal diseases but may also have application for the treatment of retinal degenerative disorders and for a form of cell-based gene therapy ...
Atsushi, Otani, Martin, Friedlander
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We discuss the potential use of stem cells for therapeutic angiogenesis in the treatment of retinal diseases. We demonstrate that the clinical utility of these EPC may be not limited in the treatment of ischemic retinal diseases but may also have application for the treatment of retinal degenerative disorders and for a form of cell-based gene therapy ...
Atsushi, Otani, Martin, Friedlander
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Transdifferentiation and retinal regeneration
Seminars in Cell Biology, 1995The neural retina of amphibians and chick embryos regenerates following damage. Retinal regeneration requires a change in the differentiated state of the cells of the pigmented epithelium of the retina to a neural progenitor phenotype. The molecular mechanisms that control the cell fate decision between these two very different cell types involves ...
T A, Reh, C, Pittack
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Müller Glia-Mediated Retinal Regeneration
Molecular Neurobiology, 2021Müller glia originate from neuroepithelium and are the principal glial cells in the retina. During retinal development, Müller glia are one of the last cell types to be born. In lower vertebrates, such as zebrafish, Müller glia possess a remarkable capacity for retinal regeneration following various forms of injury through a reprogramming process in ...
Hui Gao +4 more
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Retinal stem cells and regeneration
The International Journal of Developmental Biology, 2004The optic vesicle gives rise to several very different epithelial tissues, including the neural retina, the pigmented epithelium, the iris, the ciliary epithelium of the ciliary body and the optic stalk. Retinal regeneration can arise from several different cellular sources; in some species, the process involves interconversion, or transdifferentiation,
Ala, Moshiri +2 more
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Towards Retinal Ganglion Cell Regeneration
Regenerative Medicine, 2012Traumatic optic nerve injury and glaucoma are among the leading causes of incurable vision loss across the world. What is worse, neither pharmacological nor surgical interventions are significantly effective in reversing or halting the progression of vision loss.
Huasong, Gao +7 more
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