Results 81 to 90 of about 141,412 (299)
Advanced Science, EarlyView.Pathological retinal/choroidal neovascularization drives vision loss in DR and AMD. Current anti‐VEGF injections, while effective, require invasive, frequent administration. Pene/LQ015, is developed a novel topical anti‐VEGFA nanobody formulation achieving therapeutic intraocular levels through penetratin analog‐enhanced delivery.
Chong Chen +12 more
wiley +1 more source
Characterization of retinal vessels by fractal analysis: its importance in pathology
Applied Medical Informatics, 2019 The retinal circulation is the only part of human circulation that can be directly observed by ophthalmosopy. By this assessment, a lot of connection between the appearances of retinal microcirculation has been already established.
Adriana Elena BULBOACĂ +4 more
doaj
Clinical Ophthalmology, 2022 João Heitor Marques,1 João Coelho,1 Maria João Menéres,1,2 João Melo Beirão1,2 1Serviço de Oftalmologia, Centro Hospitalar Universitário do Porto, Porto, Portugal; 2Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto ...
Marques JH +3 more
doaj
FMO2 Promotes Angiogenesis via Regulation of N‐Acetylornithine
Advanced Science, EarlyView.This study identifies flavin‐containing monooxygenase 2 (FMO2) as a novel proangiogenic regulator in endothelial cells. Targeted FMO2 ablation impairs vessel sprouting, whereas its compensation potently enhances angiogenesis. Metabolomics and single‐cell sequencing reveal that FMO2 drives vascular growth via the N‐acetylornithine/ATF3/NOTCH1 axis ...
Jingyi Wang +15 more
wiley +1 more source
In vivo laser Doppler holography of the human retina
, 2018 The eye offers a unique opportunity for non-invasive exploration of cardiovascular diseases. Optical angiography in the retina requires sensitive measurements, which hinders conventional full-field laser Doppler imaging schemes.
Atlan, M. +4 more
core +1 more source
Multiscale Construction, Evaluation, and Application of Organoids
Advanced Science, EarlyView.Organoids are pivotal models with transformative biomedical potential. A comprehensive multi‐scale perspective is presented, encompassing dual‐scale construction, four‐dimensional evaluation, triple‐point application, and an analysis of the current challenges faced by organoid technology, aiming to advance organoid research and its biomedical ...
Wanting Ma +5 more
wiley +1 more source
The detections of retinopathy symptoms and tractional retinal detachment
Advances in Mechanical Engineering, 2016 Since the symptoms of the diabetic retinopathy, macular degeneration, and many other eye diseases are often associated with the bright spots, dark spots, and vascular abnormalities in retinal images, this study proposes a retinopathy image segmentation ...
Yi-Wen Hung +7 more
doaj +1 more source
Advanced Science, EarlyView.A high‐resolution intravital imaging platform combining functional ultrasound and localization microscopy enables longitudinal, minimally invasive assessment of cerebrovascular function in aging studies. The present investigation reveals aging‐related reductions in neurovascular coupling, arteriole‐to‐venule ratio and vascular density, introducing a ...
Sharon Negri +16 more
wiley +1 more source
A Deep Learning System for Fully Automated Retinal Vessel Measurement in High Throughput Image Analysis [PDF]
, 2022 Danli Shi +8 more
openalex +1 more source
Advanced Science, EarlyView.This review summarizes the design principles and key features of programmable hydrogels that respond to multiple stimuli. It then delves into the cutting‐edge mechanisms of self‐executing systems, highlighting their role as the cornerstone of next‐generation programmable hydrogels (NGPHs).
Guangli Xiang +8 more
wiley +1 more source