Results 101 to 110 of about 151,276 (329)
Arthritis &Rheumatology, EarlyView.Objective This study investigates the role of senescent epidermal basal cells in cutaneous lupus erythematosus (CLE) pathogenesis using skin samples from patients with CLE and a mouse model of systemic lupus erythematosus (SLE). Methods Cellular senescence profiling used datasets from the NCBI GEO database and Accelerating Medicines Partnership (AMP ...
Sena Yamamoto +13 more
wiley +1 more source
Classification and staging of retinoblastoma
Community Eye Health Journal, 2018 Classifying and staging retinoblastoma is an essential first step when planning how to manage a child with the condition; it also gives important information about prognosis.
Ido Didi Fabian +2 more
doaj
Psychometric test for blind adults and children, critical issues and perspectives [PDF]
, 2016 In literature a paucity of issues to measure cognitive functioning in the blinds is available (Rich, Anderson, 1965; Pichot, 1968; Newland, 1969; Vander Kolk, 1977; Nelson, Joyce, Dias, 2002) but in these reviews it is clear that they are not yet widely ...
Cassar, Carolina, Lucchese, Franco
core +3 more sources
Journal of Cytology, 2018 Retinoblastoma is a rare malignant tumor of the retina usually seen in children before 5 years of age. The tumor is extremely rare in adults. We report here an unusual case of retinoblastoma in a 55-year-old adult female who presented to us with an orbital mass at a late stage of the disease. Detailed laboratory investigations and imaging studies could
Pratima Khare +3 more
openaire +4 more sources
BMEMat, EarlyView.Efficient drug delivery to the posterior segment of the eye has long been a challenging issue due to the complex ocular barriers. The review focuses on the promise held by nanoplatforms for barrier penetration and the key mechanisms involved, also highlighting their advantages in achieving efficient drug delivery and superior treatment of PSEDs ...
Yifan Shen +7 more
wiley +1 more source
A national retinoblastoma network: experiences in Kenya and the UK
Community Eye Health Journal, 2018 Retinoblastoma is a rare disease. Saving the lives of the children affected requires early detection, good referral systems and expert care by a multidisciplinary team. Setting up a national and joined-up service is an essential first step.
Ashwin Reddy, Kahaki Kimani
doaj
Retinoblastoma and mosaic 13q deletion: a case report
International Journal of Retina and Vitreous, 2021 Background Patients with 13q-syndrome are at risk of retinoblastoma when the RB1 gene, located in the chromosomal band 13q14.2, is deleted. This syndrome is frequently associated with congenital malformations and developmental delay, although these signs
Pablo Gargallo +10 more
doaj +1 more source
Identification of calpain cleavage sites in the G1 cyclin-dependent kinase inhibitor p19(INK4d) [PDF]
, 2006 Calpains are a large family of Ca2+-dependent cysteine proteases that are ubiquitously distributed across most cell types and vertebrate species. Calpains play a role in cell differentiation, apoptosis, cytoskeletal remodeling, signal transduction and ...
Croall +13 more
core +2 more sources
Breaking barriers: the cGAS‐STING pathway as a novel frontier in cancer immunotherapy
Cancer Communications, EarlyView.Abstract Since its discovery, the cyclic GMP‐AMP synthase (cGAS)‐stimulator of the interferon gene (STING) signaling pathway has been considered a pivotal component of innate immunity and a promising target for cancer immunotherapy. Beyond its canonical role in pathogen defense, accumulating evidence has demonstrated that the cGAS‐STING pathway ...
Yuheng Yan +5 more
wiley +1 more source
Protein transduction: A novel tool for tissue regeneration [PDF]
, 2002 Tissue regeneration in humans is limited and excludes vitals organs like heart and brain. Transformation experiments with oncogenes like T antigen have shown that retrodifferentiation of the respective cells is possible but hard to control. To bypass the
Derer W. +4 more
core +1 more source