Results 111 to 120 of about 151,276 (329)

In Vivo Biosynthesis and Direct Incorporation of Noncanonical Amino Acids into Proteins

ChemBioChem, EarlyView.
This review evaluates engineered (semi)autonomous cell systems for the biosynthesis and incorporation of noncanonical amino acids (ncAAs) into proteins. While semi‐autonomous cells convert supplied precursors into ncAAs autonomous cells integrate biosynthetic pathways that produce these building blocks intracellularly.
Jan Hendrik Illies, Tim Moritz Weber, Ivana Drienovská   +2 more
wiley   +1 more source

Treatment of RB‐deficient retinoblastoma with Aurora‐A kinase inhibitor

Kaohsiung Journal of Medical Sciences, 2022
Retinoblastoma, also known as ocular cancer, usually affects children under the age of five. The standard of care for managing early‐stage retinoblastoma is a combination of vincristine, carboplatin, and etoposide.
Wen Yang, Xing‐Xiu Jiang, Xiao‐Yan Zhao, Ping‐An Mao   +3 more
doaj   +1 more source

Developmental stage-specific proliferation and retinoblastoma genesis in RB-deficient human but not mouse cone precursors

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Retinoblastoma is a childhood tumor that forms in response to mutations in the RB1 gene and loss of functional RB protein. Prior studies suggested that retinoblastomas arise from cone photoreceptor precursors, whereas mouse models yield ...
Hardeep P. Singh, Sijia Wang, Kevin Stachelek, Sunhye Lee, Mark W. Reid, M. Thornton, C. Craft, B. Grubbs, D. Cobrinik   +8 more
semanticscholar   +1 more source

XPO1 inhibition by selinexor induces potent cytotoxicity against high grade bladder malignancies. [PDF]

, 2018
Treatment options for high grade urothelial cancers are limited and have remained largely unchanged for several decades. Selinexor (KPT-330), a first in class small molecule that inhibits the nuclear export protein XPO1, has shown efficacy as a single ...
Baek, Han Bit, Fernandez-Rubio, Aleida, Gandour-Edwards, Regina, Ghosh, Paramita M, Landesman, Yosef, Libertini, Stephen J, Lombard, Alan P, Mudryj, Maria, Nakagawa, Rachel, Nishida, Kristine, Siddiqui, Salma, Vidallo, Kathleen, Vinall, Ruth, Weiss, Robert H, Wettersten, Hiromi   +14 more
core   +1 more source

Thermotherapy for Retinoblastoma [PDF]

Archives of Ophthalmology, 1999
To evaluate the results of thermotherapy for retinoblastoma.Prospective, nonrandomized analysis of the treatment method.A total of 188 retinoblastomas in 80 eyes of 58 patients who were treated with thermotherapy.Tumor response and ocular adverse effects.Of 188 retinoblastomas treated with thermotherapy, mean tumor base was 3.0 mm and tumor thickness ...
Gary Mercado, Carol L. Shields, Kaan Gündüz, Jacqueline Cater, Jerry A. Shields, Maria Carmen M. Santos, Waltenio Diniz   +6 more
openaire   +3 more sources

Biocompatible Chemistry: A Plug‐and‐Play Toolbox for Chemical Biology Research

ChemBioChem, EarlyView.
The “plug‐and‐play” nature of biocompatible chemistry makes it a powerful toolbox for investigating complicated biological systems and producing drug leads for clinical usages. This review summarizes the commonly used biocompatible reactions and the recent advances of their representative applications in chemical biology research, thus highlighting the
Adam R. Lovato, Zeng Lin, Qingfei Zheng
wiley   +1 more source

Gankyrin‐Protein Interactions in GI Cancers: A Novel Target of New Therapeutics

Chronic Diseases and Translational Medicine, EarlyView.
ABSTRACT Gankyrin (PSMD10) is a 25 kDa oncogenic protein and regulatory subunit of the 26S proteasome, characterized by a sevenfold ankyrin repeat domain. Gankyrin is overexpressed in various malignancies, particularly gastrointestinal (GI) cancers. Gankyrin contributes to tumorigenesis by modulating key signaling pathways and engaging in oncogenic ...
Shuang Li, Yuky Lam, Aaron Muth, Zhe‐Sheng Chen, Shanzhi Wang   +4 more
wiley   +1 more source

The Correlation between Family Socioeconomic Status and the Delayed Treatment of Retinoblastoma Patients at Dr. Soetomo General Hospital Surabaya

Juxta: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga, 2019
Introduction: Retinoblastoma is a cancer with the highest incidence in children and the second type of cancer that most often causes death in children in Indonesia. The level of delay in attending treatment for retinoblastoma patients in Dr.
Nanning Naimatuningsih, Hendrian Soebagjo, Rosy Setiawati, Rozalina Loebis   +3 more
doaj   +1 more source

Retinoblastoma tells the story of our health care system [PDF]

, 2000
Objective: To review cases of retinoblastoma. Setting: Department of Pathology Aga Khan University Hospital Karachi. Method: Twenty three specimens from cases of retinoblastoma received over a period of eight years were routinely processes and stained ...
Ahmed, Rashida, Hasan, Sheema H., Hussainy, Akbar Shah, Kayani, Naila, Khan, Muhammad Nadeem, Muzaffar, Suhail, Pervez, Shahid, Soomro, Irshad   +7 more
core   +1 more source

Gene Therapy for Pediatric Cancer: State of the Art and Future Perspectives [PDF]

, 2003
While modern treatments have led to a dramatic improvement in survival for pediatric malignancy, toxicities are high and a significant proportion of patients remain resistant.
Biagi, Ettore, Bollard, Catherine, Brenner, Malcolm, Rousseau, Raphael   +3 more
core   +5 more sources