Results 111 to 120 of about 57,195 (184)

hTERT Increases TRF2 to Induce Telomere Compaction and Extend Cell Replicative Lifespan

Aging Cell, EarlyView.
In contrast to the dogma that a subset of short telomeres initiates senescence, hTERT variants unable to maintain telomere length block senescence by stabilizing TRF2 via inhibiting upstream E3 ubiquitin ligases. This noncanonical hTERT function also compacts telomeres and blocks senescence‐associated DNA damage signaling. Cancer cells expressing hTERT
Nancy Adam, Yang Yang, Mahbod Djamshidi, Sara Seifan, Nicholas S. Y. Ting, Joel Glover, Nicolas Touret, Paul M. K. Gordon, K. V. Vineetha Warriyar, Hokan Krowicki, Christine Kim Garcia, Sharon A. Savage, Aaron A. Goodarzi, Duncan M. Baird, Tara L. Beattie, Karl Riabowol   +15 more
wiley   +1 more source

Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?

Acta Ophthalmologica, EarlyView.
Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs, Berith M. Balfoort, Marion M. Brands, Anneloor L. M. A. ten Asbroek, Camiel J. F. Boon, Roselie M. H. Diederen, Corrie Timmer, Margreet A. E. M. Wagenmakers, Hans R. Waterham, Ronald J. A. Wanders, Riekelt H. Houtkooper, Clara D. van Karnebeek, Arthur A. Bergen   +12 more
wiley   +1 more source

Unlocking the power of immune checkpoint inhibitors: Targeting YAP1 reduces anti‐PD1 resistance in skin cutaneous melanoma

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Immune checkpoint inhibitors, such as anti­PD1, revolutionized melanoma treatment. However, resistance and low response rates remain problems. Our goal was to pinpoint actionable biomarkers of resistance to anti‐PD1 treatment and verify therapeutic effectiveness in vivo.
Szonja Anna Kovács, Tamás Kovács, András Lánczky, Ágnes Paál, Zsombor I. Hegedűs, Nabil V. Sayour, Lilla Szabó, Andrea Kovács, Giampaolo Bianchini, Péter Ferdinandy, Alberto Ocana, Zoltán V. Varga, János Tibor Fekete, Balázs Győrffy   +13 more
wiley   +1 more source

Geographical Discrepancy in Medical Care Access Among Children, Adolescents, and Young Adults With Cancer in Japan, 2016–2019

Cancer Science, EarlyView.
Using nationwide cancer registry data (n = 99,968), we analyzed geographical disparities in access to cancer care among patients aged 0–39 years in Japan between 2016 and 2019. While most patients received treatment within their residential prefecture, significant variations were observed, particularly among retinoblastoma patients and those both in ...
Anna Tsutsui, Yoshitaka Murakami, Takako Fujimaki, Masayuki Endo, Yuko Ohno   +4 more
wiley   +1 more source

The Role of Histone Methyltransferase SETDB1 in Normal and Malignant Hematopoiesis

Cancer Science, EarlyView.
In this review, we discuss the role of SETDB1 in gene regulation, including an overview of its structural features and key cofactors. We also highlight the lineage‐specific roles of SETDB1 in both normal hematopoietic processes and hematological malignancies, emphasizing its function as an immune checkpoint molecule that suppresses natural killer cell ...
Yu‐Hsuan Chang, Susumu Goyama
wiley   +1 more source

Genome‐Wide Screening in Haploid Stem Cells Reveals Synthetic Lethality Targeting MLH1 and TP53 Deficient Tumours

Cell Proliferation, EarlyView.
To identify genetic events that can lead to tumour death once either MLH1 or TP53 is mutated, a genome‐wide genetic screening was performed, uncovering a list of putative hits. Synthetic lethal interactions were validated either genetically or chemically by using small molecules that inhibit these genes either in vitro and in vivo.
Rivki Cashman, Guy Haim‐Abadi, Elyad Lezmi, Hagit Philip, Jonathan Nissenbaum, Ruth Viner‐Breuer, Chen Kozulin, Tamar Golan‐Lev, Aseel Gadban, Shiri Spinner‐Potesky, Ofra Yanuka, Oded Kopper, Nissim Benvenisty   +12 more
wiley   +1 more source

Epigenetic control of cell identities from epiblast to gastrulation

The FEBS Journal, EarlyView.
In this review, we present and contextualize current knowledge about the roles of epigenetic modifiers during the development of mouse epiblast to gastrulation stage. The epigenetic regulation of enhancer and promoter elements by DNA methylation, histone modifications, and chromatin accessibility in concert with lineage‐specific transcription factors ...
Katrin M. Schüle, Simone Probst
wiley   +1 more source

Cancer and Accelerated Aging Research at the National Institutes of Health, 2013–2023: A Grant Portfolio Analysis

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background The purpose of this study was to describe the characteristics of the NIH‐funded grant portfolio focused on cancer and accelerated aging. Methods Research project grants focused on cancer survivors and aging trajectories that were newly funded during fiscal years 2013 through 2023 were identified by first using a text mining ...
Lisa Gallicchio, Rachelle Brick, Gina Tesauro, Lindsey Page, Paige Green, Jennifer L. Guida   +5 more
wiley   +1 more source

Lesions simulating retinoblastoma at a tertiary care center

Journal of Ophthalmic & Vision Research, 2015
Purpose: To determine the types and frequency of ocular conditions simulating retinoblastoma (pseudo-retinoblastoma) at Farabi Eye Hospital, Tehran, Iran.
Fariba Ghassemi, Fatemeh Bazvand, Ali Makateb   +2 more
doaj   +1 more source

Large interstitial del(13)(q13q14.3): the importance of detailed clinical information in cytogenetic studies [PDF]

, 2011
Interstitial deletions of chromosome 13 are known to be associated with retinoblastoma. A wider syndrome may accompany the deletion, including mental retardation and craniofacial dysmorphism.
Correia, Hildeberto, Fonseca Silva, Maria da Luz, Margarida, Azevedo, Mota Freitas, Manuela, Oliva Teles, Natália, Oliveira, Fernanda Paula, Ribeiro, Joana   +6 more
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