Results 121 to 130 of about 145,462 (345)

Retinoblastoma and mosaic 13q deletion: a case report

International Journal of Retina and Vitreous, 2021
Background Patients with 13q-syndrome are at risk of retinoblastoma when the RB1 gene, located in the chromosomal band 13q14.2, is deleted. This syndrome is frequently associated with congenital malformations and developmental delay, although these signs
Pablo Gargallo, Silvestre Oltra, Julia Balaguer, Honorio Barranco, Yania Yáñez, Vanessa Segura, Antonio Juan-Ribelles, Inés Calabria, Margarita Llavador, Victoria Castel, Adela Cañete   +10 more
doaj   +1 more source

Contagious obesity: from adenovirus 36 to RB dysfunction [PDF]

arXiv, 2008
Significant overweight represents a major health problem in industrialized countries. Besides its known metabolic origins, this condition may also have an infectious cause, as recently postulated. Here, it is surmised that the potentially causative adenovirus 36 contributes to such disorder by inactivating the retinoblastoma tumor suppressor protein ...
arxiv  

Signalling, cell cycle and pluripotency in embryonic stem cells [PDF]

, 2002
International ...
Burdon, Tom, Savatier, Pierre, Smith, Austin   +2 more
core   +1 more source

Human sporadic breast carcinoma histotypes driven by the Human Betaretrovirus homologous to Mouse Mammary Tumor Virus

International Journal of Cancer, EarlyView.
What's New? While estrogens, obesity, and alcohol are recognized risk factors for breast cancer, a viral hypothesis has been suggested based on the murine model of Mouse Mammary Tumor Virus (MMTV)‐induced mammary tumors. This study analyzed sequences of the human homolog of MMTV across human breast carcinoma histotypes, detecting the virus in all types
Prospero Civita, Chiara Maria Mazzanti, Francesca Lessi, Caterina Marchiò, Cristian Scatena, Michele Menicagli, Matteo Ghilli, Manuela Roncella, Antonio Giuseppe Naccarato, Anna Sapino, Jacob Hochman, Mauro Pistello, Generoso Bevilacqua   +12 more
wiley   +1 more source

Antiproliferative MCR peptides block physical interaction of insulin with retinoblastoma protein (RB) in human lung cancer cells [PDF]

arXiv, 2007
Fifteen years ago, a structural analysis of the hormone insulin and the retinoblastoma tumor suppressor protein (RB) revealed that they may physically interact with one another. Subsequently, an RB peptide corresponding to the proposed RB binding site for insulin was found to recognize full-length insulin in vitro.
arxiv  

Questionnaire study to gain an insight into the manufacturing and fitting process of artificial eyes in children: an ocularist perspective [PDF]

, 2016
Purpose To gain an insight into the manufacturing and fitting of artificial eyes in children and potential improvements to the process. Method An online qualitative survey was distributed to 39 ocularists/prosthetists in Europe and Canada ...
A Clarke, A Fink, AA Ayanniyi, Bryce Dyer, D Raizada, E McColl, G Wu, GK Goel, H Jansen, HB McBain, Holly Chinnery, Karen Rees, N Starling, P Evans, P Garg, PD Converse, R Bibb, RK Gupta, S Li, S Sofaer, S Sofaer, Siamak Noroozi, Simon B. N. Thompson, SM Shortell, SR Shaikh, TJ Hoff, VC Braun, VW Willard, W Phillips, Y Bi   +29 more
core   +2 more sources

Developmental stage-specific proliferation and retinoblastoma genesis in RB-deficient human but not mouse cone precursors

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Retinoblastoma is a childhood tumor that forms in response to mutations in the RB1 gene and loss of functional RB protein. Prior studies suggested that retinoblastomas arise from cone photoreceptor precursors, whereas mouse models yield ...
Hardeep P. Singh, Sijia Wang, Kevin Stachelek, Sunhye Lee, Mark W. Reid, M. Thornton, C. Craft, B. Grubbs, D. Cobrinik   +8 more
semanticscholar   +1 more source

Molecular subtyping and precision therapy for esophageal cancer

Interdisciplinary Medicine, EarlyView.
The molecular typing of esophageal cancer based on genome, transcriptome, proteome, and multi‐omics revealed various molecular features and provided potential targets for the precision therapy. Recent trials have shown that immunotherapy or molecular targeted therapy plus chemoradiotherapy can improve overall survival and progression‐free survival in ...
Guangkun Pei, Zhuoran Liang, Bianli Gu, Linlin Shi, Ze‐Xian Liu, Shegan Gao   +5 more
wiley   +1 more source

IGF2BP2‐induced circRNF20 facilitates breast cancer cell proliferation via the HuR/CDCA4 axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
Abstract This study aimed to explore the mechanism of insulin‐like growth factor 2 mRNA‐binding protein 2 (IGF2BP2) affecting the proliferation of breast cancer (BC) cells. The expression of IGF2BP2, circRNA ring finger protein 20 (circRNF20), and cell division cycle‐associated protein 4 (CDCA4) in human BC cells and normal breast epithelial cells was ...
Shu‐Tao Wu, Xiao‐Li Hou, Fei Wang, Wei Sun, Jia‐Jie Chen, Ya‐Sen Cao, Hong Cheng   +6 more
wiley   +1 more source

Retinoblastoma in an adult

Journal of Cytology, 2018
Retinoblastoma is a rare malignant tumor of the retina usually seen in children before 5 years of age. The tumor is extremely rare in adults. We report here an unusual case of retinoblastoma in a 55-year-old adult female who presented to us with an orbital mass at a late stage of the disease. Detailed laboratory investigations and imaging studies could
Pratima Khare, Vasudha Garg, Sonam Kumar Pruthi, A B Gupta   +3 more
openaire   +3 more sources