Results 141 to 150 of about 145,462 (345)

LncRNA AFAP1-AS1 is a prognostic biomarker and serves as oncogenic role in retinoblastoma

Bioscience Reports, 2018
The actin filament-associated protein 1 antisense RNA 1 (AFAP1-AS1) has been found to serve as an oncogenic long noncoding RNA (lncRNA) in most types of human cancer. The role of AFAP1-AS1 in retinoblastoma remains unknown.
F. Hao, Yanan Mou, Laixia Zhang, Shuna Wang, Yang Yang   +4 more
semanticscholar   +1 more source

Retinoma: An overview

Pediatric Investigation, EarlyView.
Retinoma, a benign tumor caused by biallelic retinoblastoma gene (RB1) inactivation, offers key insights into retinoblastoma development and oncogenesis. This review explores its molecular genetics, clinical features, diagnosis, management, and potential implications for advancing the prevention and treatment of retinoblastoma.
Panagiotis Toumasis, Ashwin Mallipatna, Timothy W. Corson, Helen Dimaras   +3 more
wiley   +1 more source

Nitric oxide suppression by secreted frizzled-related protein 2 drives retinoblastoma

Cell Reports, 2023
Summary: Retinoblastoma is a cancer of the infant retina primarily driven by loss of the Rb tumor suppressor gene, which is undruggable. Here, we report an autocrine signaling, mediated by secreted frizzled-related protein 2 (SFRP2), which suppresses ...
Panneerselvam Jayabal, Fuchun Zhou, Xiuye Ma, Kathryn M. Bondra, Barron Blackman, Susan T. Weintraub, Yidong Chen, Patricia Chévez-Barrios, Peter J. Houghton, Brenda Gallie, Yuzuru Shiio   +10 more
doaj  

Tumor suppressor and anti-inflammatory protein: an expanded view on insulin-degrading enzyme (IDE) [PDF]

arXiv, 2008
In 1994, I conjectured that insulin-degrading enzyme (IDE) acts as an inhibitor of malignant transformation by degrading insulin and thus preventing this major growth-stimulatory hormone from binding and thereby inactivating the retinoblastoma tumor suppressor protein (RB).
arxiv  

XPO1 inhibition by selinexor induces potent cytotoxicity against high grade bladder malignancies. [PDF]

, 2018
Treatment options for high grade urothelial cancers are limited and have remained largely unchanged for several decades. Selinexor (KPT-330), a first in class small molecule that inhibits the nuclear export protein XPO1, has shown efficacy as a single ...
Baek, Han Bit, Fernandez-Rubio, Aleida, Gandour-Edwards, Regina, Ghosh, Paramita M, Landesman, Yosef, Libertini, Stephen J, Lombard, Alan P, Mudryj, Maria, Nakagawa, Rachel, Nishida, Kristine, Siddiqui, Salma, Vidallo, Kathleen, Vinall, Ruth, Weiss, Robert H, Wettersten, Hiromi   +14 more
core   +1 more source

Early Initiation of Adjuvant Therapy Following Pediatric Endoscopic Endonasal Surgery for Tumors

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective To evaluate complication rates of early adjuvant therapy initiation in pediatric patients with endoscopic endonasal resection for skull base tumors. Design Retrospective case series of pediatric patients (0–18 years old) with skull base tumors who underwent endoscopic endonasal resection between 2013 and 2023.
Heta Patel, Alan D. Workman, David K. Lerner, Phillip J. Storm, Jennifer E. Douglas, Nithin D. Adappa, James N. Palmer, Michael A. Kohanski   +7 more
wiley   +1 more source

Retinoblastoma tells the story of our health care system [PDF]

, 2000
Objective: To review cases of retinoblastoma. Setting: Department of Pathology Aga Khan University Hospital Karachi. Method: Twenty three specimens from cases of retinoblastoma received over a period of eight years were routinely processes and stained ...
Ahmed, Rashida, Hasan, Sheema H., Hussainy, Akbar Shah, Kayani, Naila, Khan, Muhammad Nadeem, Muzaffar, Suhail, Pervez, Shahid, Soomro, Irshad   +7 more
core   +1 more source

Interventional oncology in children: Where are we now?

Journal of Medical Imaging and Radiation Oncology, EarlyView.
Abstract Paediatric Interventional Oncology (IO) lags behind adult IO due to a scarcity of specific outcome data. The suboptimal way to evolve this field is relying heavily on adult experiences. The distinct tumour types prevalent in children, such as extracranial germ cell tumours, sarcomas, and neuroblastoma, differ strongly from those found in ...
Premal Amrishkumar Patel, Fernando Gómez Muñoz   +1 more
wiley   +1 more source

MicroRNA-101-3p inhibits proliferation in retinoblastoma cells by targeting EZH2 and HDAC9

Experimental and Therapeutic Medicine, 2018
Retinoblastoma is the most frequent intraocular malignant tumor type to occur in childhood. MicroRNA (miR)-101-3p has been reported to function as a tumor suppressor in various types of cancer.
Q. Jin, Wen-feng He, Leifeng Chen, Yang Yang, K. Shi, Zhipeng You   +5 more
semanticscholar   +1 more source

Recent Developments in Retinoblastoma

Delhi Journal of Ophthalmology, 2016
Retinoblastoma represents 3% of all childhood cancers, and is the most common intraocular malignancy of childhood. It is fatal if untreated. The management of retinoblastoma has gradually evolved over the past few decades, with an aim to not only ...
Raksha Rao, Santosh G Honavar
doaj   +1 more source