Results 151 to 160 of about 151,276 (329)
E2F4 regulates transcriptional activation in mouse embryonic stem cells independently of the RB family. [PDF]
, 2019 E2F transcription factors are central regulators of cell division and cell fate decisions. E2F4 often represents the predominant E2F activity in cells.
Arand, Julia +10 more
core
Tumour progression shows decrease in PD‐L1 expression in matched metastases/primary uveal melanomas
Acta Ophthalmologica, EarlyView.Abstract Purpose Immune checkpoint inhibitors (ICI) have revolutionised the treatment of several malignancies. However, the results of ICI therapy remain unsatisfactory in metastatic uveal melanoma (UM). We analysed the expression of PD1, PD‐L1, T‐cell and macrophage markers in a set of matched primary and metastatic UM in an attempt to better ...
Maria Chiara Gelmi +5 more
wiley +1 more source
Genetics and management of retinoblastoma
Journal of Indian Association of Pediatric Surgeons, 2007 Retinoblastoma is the most common intraocular tumor in childhood. In majority of early stage retinoblastoma, the eyeballs as well as vision can be preserved with chemotherapy and local intraocular therapy with laser or photocoagulation.
Bakhshi Sameer, Bakhshi Radhika
doaj
MicroRNA-101-3p inhibits proliferation in retinoblastoma cells by targeting EZH2 and HDAC9
Experimental and Therapeutic Medicine, 2018 Retinoblastoma is the most frequent intraocular malignant tumor type to occur in childhood. MicroRNA (miR)-101-3p has been reported to function as a tumor suppressor in various types of cancer.
Q. Jin +5 more
semanticscholar +1 more source
Cancer Science, EarlyView.Just as the term “cancer cell” encompasses a wide spectrum of cells, the term “senescent cell” should also be regarded as an umbrella term that includes cells with heterogeneous molecular profiles. In this review, we provide an updated overview of the molecular mechanisms underlying distinct senescent cell subtypes induced by various stimuli, including
Enaam Alghamdi, Keiko Kono
wiley +1 more source
Cell Death and Disease, 2018 UHRF1 (ubiquitin-like with PHD and ring finger domains 1) is highly expressed in various human cancers including retinoblastoma, and associated with tumor-promoting effects such as inhibition of apoptosis and high proliferation.
Heng He, Chunsik Lee, Jong Kyong Kim
semanticscholar +1 more source
Smartphone-based, rapid, wide-field fundus photography for diagnosis of pediatric retinal diseases [PDF]
, 2019 PurposeAn important, unmet clinical need is for cost-effective, reliable, easy-to-use, and portable retinal photography to evaluate preventable causes of vision loss in children.
Besirli, Cagri G. +10 more
core +2 more sources
Cell-Penetrating Peptides, Electroporation, and Drug Delivery
, 2010 Certain short polycations, such as TAT and oligoarginine, rapidly pass through the plasma membranes of mammalian cells by a mechanism called transduction, as well as by endocytosis and macropinocytosis.
Cahill, Kevin
core +1 more source
Investigating Microinvasive Intra‐Ocular Biopsy
Clinical &Experimental Ophthalmology, EarlyView.ABSTRACT Background Current minimally invasive methods of intraocular biopsy are confined to small gauge (G) needles and subretinal cannulae that can be prone to wound leakage at the biopsy site. We investigate the role of microneedles with internal diameters as small as 49G for intraocular biopsy in the posterior and anterior segments.
Jared Ching +3 more
wiley +1 more source