Results 151 to 160 of about 145,462 (345)

Tigecycline as a dual inhibitor of retinoblastoma and angiogenesis via inducing mitochondrial dysfunctions and oxidative damage

Scientific Reports, 2018
Retinoblastoma is the most common intraocular malignancy in children with poor prognosis. The progression of retinoblastoma is dependent on a robust angiogenic response.
Ying Xiong, Wei Liu, Qian Huang, Jierong Wang, Yanjun Wang, Huijuan Li, Xuedong Fu   +6 more
semanticscholar   +1 more source

Adjuvant therapy for children treated by enucleation at diagnosis of retinoblastoma

EJC Paediatric Oncology, 2023
Introduction: Advanced localized retinoblastoma can be cured by enucleation, but extraocular spread of retinoblastoma cells is associated with a high mortality.
Yelena Diarra, Christina Brockmeyer, Karen Fischhuber, Isabel Hülsenbeck, Saskia Ting, Madlen Reschke, Tobias Kiefer, Anna Hannbücken, Maren Wagemanns, Leyla Jabbarli, Selma Sirin, Regina Wieland, Gudrun Fleischhack, Johannes H. Schulte, Martin Ebinger, Dietmar Lohmann, Bert Müller, Daniela Süsskind, Christoph Schwab, Ines Brecht, Angelika Eggert, Stefan Schönberger, Petra Ritter-Sovinz, Nikolaos Bechrakis, Sophia Göricke, Beate Timmermann, Eva Biewald, Petra Ketteler   +27 more
doaj  

UHRF1 depletion sensitizes retinoblastoma cells to chemotherapeutic drugs via downregulation of XRCC4

Cell Death and Disease, 2018
UHRF1 (ubiquitin-like with PHD and ring finger domains 1) is highly expressed in various human cancers including retinoblastoma, and associated with tumor-promoting effects such as inhibition of apoptosis and high proliferation.
Heng He, Chunsik Lee, Jong Kyong Kim
semanticscholar   +1 more source

Elevated p16Ink4a Expression Enhances Tau Phosphorylation in Neurons Differentiated From Human‐Induced Pluripotent Stem Cells

Aging Cell, EarlyView.
We created an inducible system to control the expression of p16, and found that tau phosphorylation was enhanced upon p16 up‐regulation in neurons differentiated from human iPSCs. As p16 expression is increased during aging, our findings suggest a possible role of age‐associated p16 up‐regulation in Alzheimer's disease. As pathological tau tangles have
Kristopher Holloway, Kashfia Neherin, Yingduo Song, Kazuhito Sato, Andrew Houston, Feng Chen, Li Ding, Hong Zhang   +7 more
wiley   +1 more source

Scleral ectasia stabilization following intra-arterial chemotherapy in an eye with recurrent retinoblastoma

American Journal of Ophthalmology Case Reports, 2023
Purpose: To report a case of recurrent retinoblastoma following transpupillary thermotherapy (TTT) with development of scleral ectasia, as well as their successful treatment with intra-arterial chemotherapy.
Warren Pan, Neeraj Chaudhary, Laura Sedig, Amy Edmonds, Raymond Hutchinson, Hakan Demirci   +5 more
doaj  

Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle. [PDF]

, 1996
Viral oncoproteins that inactivate the retinoblastoma tumor suppressor protein (pRb) family both block skeletal muscle differentiation and promote cell cycle progression.
Jacks, T, Lassar, AB, Mulligan, GJ, Novitch, BG   +3 more
core  

Inheritance of retinoblastoma. [PDF]

, 1969
Clare Banks
openalex   +1 more source

“Monoallelic germline methylation and sequence variant in the promoter of the RB1 gene: a possible constitutive epimutation in hereditary retinoblastoma”

Clinical Epigenetics, 2016
BackgroundRetinoblastoma is a malignant tumor of the retina in children  G; −188T > G] sequence variant that is found in peripheral blood lymphocytes and tumor DNA.
Guadalupe Quiñonez-Silva, Mercedes Dávalos-Salas, F. Recillas-Targa, P. Ostrosky-Wegman, Diego Arenas Aranda, L. Benítez-Bribiesca   +5 more
semanticscholar   +1 more source

Altered retinal vasculature in childhood cancer survivors: Data from the German CVSS‐study

Acta Ophthalmologica, EarlyView.
Abstract Aims Childhood cancer is a risk factor for cardiovascular diseases in later life. Retinal examination allows to non‐invasively observe the vasculature of an end‐organ. We observe alterations in long‐term childhood cancer survivors (CCS). Methods In the Cardiac and Vascular Late Sequelae in Long‐Term Survivors of Childhood Cancer‐Study, 1002 ...
Alexander K. Schuster, Anna Maria Voigt, Tamara Jäger, Stefan Nickels, Andreas Schulz, Jörg Faber, Arthur Wingerter, Hiltrud Merzenich, Irene Schmidtmann, Manfred E. Beutel, Thomas Münzel, Karl J. Lackner, Norbert Pfeiffer, Philipp S. Wild   +13 more
wiley   +1 more source

Retinoblastoma and deletion D (14) syndrome. [PDF]

, 1969
Miriam G. Wilson, John Melnyk, J W Towner   +2 more
openalex   +1 more source