Results 251 to 260 of about 5,117,644 (334)

Humeroradial Synostosis: An Updated Classification and Differential Diagnosis Based on Genetic Aetiology

Clinical Genetics, EarlyView.
The proposed updated classification of humeroradial synostosis is based on the molecular pathways of the genes involved: (1) chondrogenesis and osteogenesis; (2) limb development and patterning; (3) genome regulation. Thus, pathologies belonging to the same molecular type may have overlapping clinical phenotypes, helping to structure the diagnostic ...
Fiona Leduc, Clémence Vanlerberghe, Fabienne Escande, Perrine Brunelle, Florence Petit, Anne Dieux   +5 more
wiley   +1 more source

Vitamin A retinoic acid contributes to muscle stem cell and mitochondrial function loss in old age. [PDF]

JCI Insight
Fraczek PM, Duran P, Yang BA, Ferre V, Alawieh L, Castor-Macias JA, Wong VT, Guzman SD, Piotto C, Itsani K, Larouche JA, Aguilar CA.   +11 more
europepmc   +1 more source

A novel mechanism of action for v-ErbA: Abrogation of the inactivation of transcription factor AP-1 by retinoic acid and thyroid hormone receptors

, 1991
Christelle Desbois, Denise Aubert, Claude Legrand, Bertrand Pain, Jacques Samarut   +4 more
openalex   +2 more sources

Loss of 18q Alters TGFβ Signalling Affecting Anteroposterior Neuroectodermal Fate in Human Embryonic Stem Cells

Cell Proliferation, EarlyView.
hESCsdel18q exhibit delayed and impaired anterior neuroectoderm induction, leading to deficient RPE specification. hESCsdel18q lines showed dysregulation of TGFβ signalling, and endogenous overactivation of activin/nodal/TGFβ in hESCsdel18q leads to improper anterior/posterior neuroectodermal fate commitments.
Yingnan Lei, Mai Chi Duong, Nuša Krivec, Charlotte Janssens, Marius Regin, Anfien Huyghebaert, Edouard Couvreu de Deckersberg, Karen Sermon, Diana Al Delbany, Claudia Spits   +9 more
wiley   +1 more source

Enhancing plasmacytoid dendritic cell functionality with <i>all-trans</i> retinoic acid for improved multiple myeloma therapy. [PDF]

Mol Ther Oncol
Yu W, Tang W, Lin W, Jiang L, Xiang Y, Li Y, Zhou Y, Chen Y, Zhao W, Zhu Y, Wei X, Hu Y, Bi E.   +12 more
europepmc   +1 more source

Rapid and Effective Neuronal Conversion of Human Glioblastoma In Vitro and In Vivo Using Potent Small Molecules

Cell Proliferation, EarlyView.
A potent combination of small molecules YFSS (Y27632, Forskolin, SB431542, SP600125) that were screened through a neuronal‐specific promoter–reporter system TUBB3::mCherry effectively induces neuronal‐GBM conversion in vitro and in vivo, unveiling molecular mechanisms that offer a theoretical basis and a potential therapeutic strategy for treating GBM.
Ya'nan Hu, Jinming Liu, Jian Tu, Min Yang, Qisheng He, Fei Li, Xiaojing Xu, Zhongqing Ji, Jianwei Xu, Wentao Zhong, Mengwen Yan, Ying Yang, Huanxiang Zhang   +12 more
wiley   +1 more source

Retinoic Acid Regulates Allergic Inflammation via Limiting Mast Cell Activation. [PDF]

Food Sci Nutr
Zhang W, Dai W, Xie Y, Chen X, Zhang P, Cui W.   +5 more
europepmc   +1 more source

Dual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure

Cell Proliferation, EarlyView.
This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.
Defeng Guan, Zhou Chen, Yuhua Zhang, Wenjie Sun, Lifei Li, Xia Huang   +5 more
wiley   +1 more source

A drug that induces the microRNA miR-124 enables differentiation of retinoic acid-resistant neuroblastoma cells. [PDF]

Sci Signal
Nguyen LD, Sengupta S, Cho KI, Floru A, George RE, Krichevsky AM.   +5 more
europepmc   +1 more source

Retinoic acid induction of human cellular retinoic acid-binding protein-II gene transcription is mediated by retinoic acid receptor-retinoid X receptor heterodimers bound to one far upstream retinoic acid-responsive element with 5-base pair spacing.

, 1994
Anders Åström, U. Pettersson, Pascal Chambon, John J. Voorhees   +3 more
openalex   +1 more source