Results 101 to 110 of about 121,956 (356)

Treatment Survival in Patients With Hidradenitis Suppurativa

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Despite the existence of therapeutic approaches, effective management of hidradenitis suppurativa (HS) remains elusive in many cases. In addition, most of the current studies focus on treatment response in a cross‐sectional analysis of patients, and therefore a proper study analysing different treatment strategies longitudinally in ...
Lea Schulte‐Oestrich, Simone Cazzaniga, Robert E. Hunger, S. Morteza Seyed Jafari   +3 more
wiley   +1 more source

Retinoid-binding proteins: mediators of retinoid action [PDF]

Biochemical Journal, 2000
Active vitamin A metabolites, known as retinoids, are essential for multiple physiological processes, ranging from vision to embryonic development. These small hydrophobic compounds associate in vivo with soluble proteins that are present in a variety of cells and in particular extracellular compartments, and which bind different types of retinoids ...
openaire   +3 more sources

Mycosis Fungoides in Paediatric Patients: A Real‐Life Retrospective Study

JEADV Clinical Practice, EarlyView.
Our study represents the largest cohort of children with MF worldwide, providing relevant evidence supporting phototherapy as first‐line treatment, with an overall remission rate of 36.36%. Both topical and systemic therapy also showed favourable outcomes.
Mariana de la Vega, María Antonieta Domínguez Gómez, Martha Alejandra Morales‐Sánchez   +2 more
wiley   +1 more source

Efficacy and Tolerability of Brodalumab in 42 Adult Patients With Moderate to Severe Psoriasis: First French Real‐Life Case Series on Hard‐to‐Treat Areas

JEADV Clinical Practice, EarlyView.
In our real‐life study, brodalumab demonstrates clinical efficacy on psoriasis lesions over a median duration of treatment of 4 months, associated with mean reductions of 94.3% for BSA, 93.1% for PASI and 88.0% for PGA. 23 patients no longer had a single lesion at the follow‐up visit.
Marc Perrussel, Bruno Sassolas
wiley   +1 more source

Germline Disruption of Retinal Pigment Epithelium-Expressed Zebrafish rlbp1b^-/- Results in Selective Dim Light Visual Behavior Deficits and Provides a Screening Platform for Evaluating the Pathogenicity of Human RLBP1 Variants. [PDF]

FASEB J
RLBP1 is a gene that is mutated in several different inherited retinal diseases (IRDs). Here we investigate the consequences of loss of RPE expressed zebrafish Cralbpb using CRISPR knockout models. These consequences include impaired dim light OKR behaviour, altered retinoid profiles, and a disrupted proteomic profile.
Fehilly JD, McCann T, Ruddin G, Kaylor JJ, Grenville H, Ward R, Wynne K, Sánchez AG, Strachan E, Travis GH, Collery RF, Kennedy BN.   +11 more
europepmc   +2 more sources

Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells.

Proceedings of the National Academy of Sciences of the United States of America, 2006
Aldehyde dehydrogenase (ALDH) is an enzyme that is expressed in the liver and is required for the conversion of retinol (vitamin A) to retinoic acids. ALDH is also highly enriched in hematopoietic stem cells (HSCs) and is considered a selectable marker ...
J. Chute, Garrett G. Muramoto, J. Whitesides, M. Colvin, R. Safi, N. Chao, D. McDonnell   +6 more
semanticscholar   +1 more source

The Impact of Methotrexate on Cardiovascular Outcomes in Psoriasis: A Systematic Review and Meta‐Analysis

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Psoriasis is a chronic immune‐mediated inflammatory disease with a global prevalence of 2%–3% and 1.3% in Brazil. It is associated with comorbidities such as obesity, hypertension, and diabetes, all of which contribute to increased cardiovascular risk due to systemic inflammation and endothelial dysfunction.
Tiago A. S. Costa, Sheila T. K. Medorima, Renata F. Magalhães   +2 more
wiley   +1 more source

Determination of binding affinities of retinoids to retinoic acid-binding protein and serum albumin [PDF]

, 1978
Brahma P. Sani, Belinda C. Titus, Chandra K. Banerjee   +2 more
openalex   +1 more source

RPE65 is the isomerohydrolase in the retinoid visual cycle.

Proceedings of the National Academy of Sciences of the United States of America, 2005
RPE65 is an abundant protein in the retinal pigment epithelium. Mutations in RPE65 are associated with inherited retinal dystrophies. Although it is known that RPE65 is critical for regeneration of 11-cis retinol in the visual cycle, the function of ...
G. Moiseyev, Ying Chen, Yusuke Takahashi, Bill X. Wu, Jian-xing Ma   +4 more
semanticscholar   +1 more source

Structure-based analysis of the ultraspiracle protein and docking studies of putative ligands [PDF]

, 2002
The ultraspiracle protein (USP) is the insect ortholog of the mammalian retinoid X receptor (RXR). Fundamental questions concern the functional role of USP as the heterodimerization partner of insect nuclear receptors such as the ecdysone receptor.
Billas, Isabelle M.L., Iwema, Thomas, Moras, Dino, Sasorith, Souphatta, Wurtz, Jean-Marie   +4 more
core   +3 more sources