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Retinoids and the Eye

Dermatologic Clinics, 1992
Systemic retinoids are being used more frequently to treat various disorders of the skin, particularly disorders of keratinization. They are promising agents for chemoprevention of cancer and as such may be widely used in the future. Both natural and synthetic retinoids may affect the eye, both on the surface epithelium and the visual metabolism. Three
Maxwell A. Helfgott, Earl G. Gross
openaire   +3 more sources

Retinoids

2017
Vitamin A, a fat-soluble vitamin, is necessary for the development and maintenance of the organism for differentiation, growth, embryonic development, and homeostasis. Many natural and synthetic compounds are developed as potential pharmacologic agents for use in treating ailments ranging from cancer to acne.
Sinan Ince   +2 more
openaire   +2 more sources

Retinoide in der Dermatopharmakologie

Der Hautarzt, 2014
Retinoids are important in regulating cell proliferation and differentiation and play an important role in the body, including the skin.Our objective is to review the current medical literature regarding use, effects and side-effects of topical and systemic retinoids used for therapy.Pubmed/Medline electronic database was searched for relevant German ...
J. M. Baron, Philipp M. Amann, H.F. Merk
openaire   +2 more sources

Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain.

Science, 2000
The retinoid X receptor (RXR) is a nuclear receptor that functions as a ligand-activated transcription factor. Little is known about the ligands that activate RXR in vivo. Here, we identified a factor in brain tissue from adult mice that activates RXR in
A. M. D. Urquiza   +6 more
semanticscholar   +1 more source

Retinoids and Contraception

Dermatology, 1992
The main side effect of the retinoids is teratogenicity. Every dermatologist has a moral obligation to ensure that this effect is avoided, and the present publication is aimed at helping prescribe these drugs. After a review of the key properties of each of the retinoids on the market, the different forms of contraception available and their indication
Serfaty D, Lefrancq H, Ceyrac Dl
openaire   +3 more sources

History of retinoids [PDF]

open access: possibleJournal of the American Academy of Dermatology, 1982
The historical development of the chemistry and biology of vitamin A and its derivatives (retinoids) is briefly reviewed.
openaire   +2 more sources

An overview of the retinoids

The American Journal of Medicine, 1989
The retinoids, a group of compounds consisting of vitamin A and its derivatives, have been the subject of intense investigation over the past 30 years. These molecules have shown beneficial effects in the areas of acne, psoriasis, neoplastic processes and, most recently, reversal of extrinsically aged skin.
openaire   +3 more sources

Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis.

Annual Review of Pharmacology and Toxicology, 2006
Retinoic acid (RA) is involved in vertebrate morphogenesis, growth, cellular differentiation, and tissue homeostasis. The use of in vitro systems initially led to the identification of nuclear receptor RXR/RAR heterodimers as possible transducers of the ...
M. Mark, N. Ghyselinck, P. Chambon
semanticscholar   +1 more source

Retinoids as Teratogens

Annual Review of Nutrition, 1995
Vitamin A is a necessary nutrient in the diet. However, excessive doses of retinoids by pregnant women result in teratogenesis. In this chapter, we initially discuss the occurrence and characteristics of fetal malformations associated with maternal ingestion of natural and synthetic retinoids in both experimental animals and humans.
Kenneth J. Soprano   +1 more
openaire   +3 more sources

Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acid.

European Journal of Biochemistry, 2000
Vitamin A (retinol) and provitamin A (beta-carotene) are metabolized to specific retinoid derivatives which function in either vision or growth and development.
G. Duester
semanticscholar   +1 more source

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