Results 211 to 220 of about 905,398 (250)

Retinoids: transport, metabolism, and mechanisms of action

Journal of Endocrinology, 1995
Abstract The retinoids comprise a family of polyisoprenoid lipids that includes vitamin A (retinol) and structurally related compounds. The biological activity of retinoids can be modified, for example, by changes in the molecules' state of oxidation and cis/trans isomerization.
A V, Vieira, W J, Schneider, P M, Vieira
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Retinoid binding-proteins redirect retinoid metabolism: biosynthesis and metabolism of retinoic acid

Seminars in Cell & Developmental Biology, 1997
Many tissues and cell types, starting early in embryogenesis, convert retinol (vitamin A) into an active form, all-trans-retinoic acid. This article will discuss a current model of retinol and retinoic acid metabolism that integrates the various reactions which maintain retinoic acid homeostasis, and will also integrate the enzymology with the ...
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The Role of Metabolism and Toxicokinetics in Retinoid Teratogenesis

Current Pharmaceutical Design, 2001
Retinoids (vitamin A and its analogs) exert profound effects on a wide variety of life processes, including morphogenesis and embryonic development. Several retinoids are also effective drugs for therapy of skin diseases and some types of cancer. However, the applicability of this class of compounds is limited by their teratogenic activity.
G, Tzimas, H, Nau
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[Metabolism of vitamin A and retinoids].

Bulletin du cancer, 1986
Dietary vitamin A is stored in the liver as ester derivatives; after hydrolysis it is transported through the organism bound to a Retinol Binding Protein-Prealbumin complex. Intracellular metabolism is complex and involves the binding to specific receptors for retinol (CRBP) and retinoic acid (CRABP) followed by a nuclear translocation.
J C, Jardillier, A, Rallet
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Changes in lipid metabolism during retinoid administration

Journal of the American Academy of Dermatology, 1982
Administration of oral vitamin A and the synthetic retinoids to humans and experimental animals has been accompanied by changes in lipid metabolism. these changes include alterations in serum, liver, and skin surface lipids. While the immediate cause(s) of the serum and liver changes remain(s) obscure, the skin surface lipid alterations appear to be ...
L E, Gerber, J W, Erdman
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Retinoid metabolism in the embryo

2000
In 1982, isotretinoin (Accutane) was marketed as an agent for treatment of acne. As early as 1983, Franz Rosa, MD, an official of the Federal Drug Administration (FDA), reported five cases of malformations associated with use of Accutane in pregnancy [1]. The malformations were major and included hydrocephalus, cardiovascular and ear defects [2 3].
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[Retinoid metabolism and cancer].

Medecine sciences : M/S, 2007
Retinoids play important roles in cell differentiation and apoptosis, notably in epithelial tissues. Their utility in cancer therapy has been demonstrated in specific cancer types. Use of retinoic acid (RA) in the treatment of acute promyelocytic leukemia was the first successful example of retinoid-based differentiation therapy.
Maxime, Parisotto, Hélène, Brodeur, Pangala V, Bhat, Sylvie, Mader   +3 more
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Retinoid Metabolism During Intestinal Absorption

The Journal of Nutrition, 1993
A number of enzymes have been described that might participate in the metabolism of dietary carotenes and retinyl esters necessary for absorption. For several steps two or more different activities are known. Which of the candidate enzymes actually is important in normal physiology is generally not known with any certainty.
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[Retinoids and lipid metabolism].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1986
Since systemic administration of synthetic retinoids was introduced into dermatology and oncology, side-effects of synthetic vitamin-A derivatives on lipid and lipoprotein metabolism have become apparent. Retinoids of the first and second generation, 13-cis-retinoic acid and etretinate, are capable of inducing secondary hyperlipoproteinemias.
B, Melnik, G, Plewig
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Regulation of lipid and lipoprotein metabolism by retinoids

Journal of the American Academy of Dermatology, 2001
Retinoids are small vitamin A-derived lipophilic compounds that influence a wide variety of developmental and metabolic processes. Retinoids exert their action by activating transcription factors belonging to the retinoic acid receptor (RAR) and retinoid X receptor (RXR) subfamilies of nuclear receptors.
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