Results 11 to 20 of about 6,765,357 (233)
Retinoid X Receptor Antagonists [PDF]
International Journal of Molecular Sciences, 2018 Retinoid X receptor (RXR) antagonists are not only useful as chemical tools for biological research, but are also candidate drugs for the treatment of various diseases, including diabetes and allergies, although no RXR antagonist has yet been approved for clinical use.
Hiroki Kakuta, Masaki Watanabe
exaly +4 more sources
Retinoid X Receptor Activation Prevents Diabetic Retinopathy in Murine Models [PDF]
Cells, 2023 Previously, the RXR agonist UAB126 demonstrated therapeutic potential to treat obese mice by controlling blood glucose levels (BGL) and altering the expression of genes associated with lipid metabolism and inflammatory response.
Iuliia Dorofeeva +7 more
doaj +4 more sources
Structural basis of the farnesoid X receptor/retinoid X receptor heterodimer on inverted repeat DNA [PDF]
Computational and Structural Biotechnology Journal, 2023 Farnesoid X receptor (FXR) is a ligand-activated transcription factor known as bile acid receptor (BAR). FXR plays critical roles in various biological processes, including metabolism, immune inflammation, liver regeneration and liver carcinogenesis. FXR
Longying Jiang +8 more
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Of Retinoids and Organotins: The Evolution of the Retinoid X Receptor in Metazoa [PDF]
Biomolecules, 2020 Nuclear receptors (NRs) are transcription factors accomplishing a multiplicity of functions, essential for organismal homeostasis. Among their numerous members, the retinoid X receptor (RXR) is a central player of the endocrine system, with a singular ...
Elza Fonseca +5 more
doaj +5 more sources
Retinoid X receptor heterodimers in hepatic function: structural insights and therapeutic potential [PDF]
Frontiers in PharmacologyNuclear receptors (NRs) are key regulators of multiple physiological functions and pathological changes in the liver in response to a variety of extracellular signaling changes.
Renjie Xu +3 more
doaj +4 more sources
Diseases, 2014 Hepatocellular carcinoma (HCC) is an aggressive disease with poor prognosis due to its high rate of recurrence after the initial curative treatment. Therefore, development of effective therapeutic strategies that can prevent recurrence and secondary ...
Hiroyasu Sakai +2 more
doaj +4 more sources
Retinoid-X receptor action and disruption in development. [PDF]
Dev BiolAcross the animal kingdom, many developmental programs require retinoid X receptor (RXR) expression. RXR is a unique member of the nuclear receptor (NRs) superfamily of transcription factors. Most famously, it serves as a mandatory heterodimer partner for a third of the other vertebrate NRs, such as retinoic acid receptors (RARs), thyroid hormone ...
Mengeling BJ, Furlow JD.
europepmc +3 more sources
Dietary Phenolic Compounds Exert Some of Their Health-Promoting Bioactivities by Targeting Liver X Receptor (LXR) and Retinoid X Receptor (RXR) [PDF]
Foods, 2023 Consuming foods of vegetable origin has been shown to exert multiple health-related effects, many of them attributed to their phenolic compounds. These molecules are known for being bioactive across multiple cells and organs, with documented changes in ...
J. Abraham Domínguez-Avila
doaj +2 more sources
Remyelination in humans due to a retinoid‐X receptor agonist is age‐dependent [PDF]
Annals of Clinical and Translational Neurology, 2022 Remyelination efficiency declines with advancing age in animal models, but this has been harder to demonstrate in people with multiple sclerosis. We show that bexarotene, a putatively remyelinating retinoid‐X receptor agonist, shortened the visual evoked
Christopher E. McMurran +7 more
doaj +2 more sources
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background The molecular mechanisms through which high‐demand pacing induce myocardial dysfunction remain unclear. Methods and Results We created atrioventricular block in pigs using dependent right ventricular septal pacing for 6 months ...
Yu‐Sheng Lin +8 more
doaj +3 more sources