Results 31 to 40 of about 6,765,357 (233)

An antagonist of the retinoid X receptor reduces the viability of Trichuris muris in vitro. [PDF]

, 2014
Background Trichuriasis is a parasitic disease caused by the human whipworm, Trichuris trichiura. It affects millions worldwide, particularly in the tropics.
Burgis, T., Else, K.J., Gallagher, A.L., Partridge, F.A., Sattelle, D.B., Hurst, R.J., Hopwood, T.   +6 more
core   +1 more source

Retinoid regulated macrophage cholesterol efflux involves the steroidogenic acute regulatory protein

Data in Brief, 2016
Elimination of excess cholesteryl esters from macrophage-derived foam cells is known to be a key process in limiting plaque stability and progression of atherosclerotic lesions.
Pulak R. Manna
doaj   +1 more source

1,25(OH)2 vitamin D3, and retinoic acid antagonize endothelin-stimulated hypertrophy of neonatal rat cardiac myocytes. [PDF]

, 1996
1,25 (OH)(2) Vitamin D-3 (VD3) and retinoic acid (RA) function as ligands for nuclear receptors which regulate transcription, Though the cardiovascular system is not thought to represent a classical target for these ligands, it is clear that both cardiac
Gardner, D. G., J Wu, Garami, Miklós, Cheng, T., T Cheng, Wu, J., M Garami, D G Gardner   +7 more
core   +1 more source

Retinoid X Receptor α-Dependent HBV Minichromosome Remodeling and Viral Replication

Annals of Hepatology, 2017
Background and aim. The HBV covalently closed circular DNA (cccDNA) is organized into a minichromosome in the nuclei of infected hepatocytes through interactions with histone and nonhistone proteins.
Yan Zhang, Song He, Jin-Jun Guo, Hong Peng, Jia-Hao Fan, Qing-Ling Li   +5 more
doaj   +1 more source

Activation of peroxisome proliferator-activated receptor alpha in human peripheral blood mononuclear cells reveals an individual gene expression profile response [PDF]

, 2007
Peripheral blood mononuclear cells (PBMCs) are relatively easily obtainable cells in humans. Gene expression profiles of PBMCs have been shown to reflect the pathological and physiological state of a person.
Afman, Lydia A., Bouwens, M., Müller, Michael, Müller Michael, Afman, Lydia, Afman, Lydia A, Afman, L.A., Michael Müller, Bouwens Mark, Müller, M.R., Mark Bouwens, Afman Lydia A, Bouwens, Mark, Lydia A Afman   +13 more
core   +1 more source

Identification of Macrophage Genotype and Key Biological Pathways in Circulating Angiogenic Cell Transcriptome

Stem Cells International, 2019
Background. Circulating angiogenic cells (CAC) have been identified as important regulators of vascular biology. However, there is still considerable debate about the genotype and function of CAC. Methods and Results.
Bert R. Everaert, Steven J. Van Laere, Robrecht Lembrechts, Vicky Y. Hoymans, Jean-Pierre Timmermans, Christiaan J. Vrints   +5 more
doaj   +1 more source

Bovine cumulus-granulosa cells contain biologically active retinoid receptors that can respond to retinoic acid

Reproductive Biology and Endocrinology, 2003
Retinoids, a class of compounds that include retinol and its metabolite, retinoic acid, are absolutely essential for ovarian steroid production, oocyte maturation, and early embryogenesis.
Malayer Jerry, Thirumalapura Nagaraja, Mohan Mahesh   +2 more
doaj   +1 more source

Mediation of antiinflammatory effects of Rg3-enriched red ginseng extract from Korean Red Ginseng via retinoid X receptor α–peroxisome-proliferating receptor γ nuclear receptors

Journal of Ginseng Research, 2019
Background: Ginseng has a wide range of beneficial effects on health, such as the mitigation of minor and major inflammatory diseases, cancer, and cardiovascular diseases. There are abundant data regarding the health-enhancing properties of whole ginseng
Evelyn Saba, Muhammad Irfan, Dahye Jeong, Kashif Ameer, Yuan Yee Lee, Chae-Kyu Park, Seung-Bok Hong, Man Hee Rhee   +7 more
doaj   +1 more source

Developmental and tissue-specific involvement of peroxisome proliferator-activated receptor-alpha in the control of mouse uncoupling protein-3 gene expression. [PDF]

, 2013
Uncoupling protein-3 (UCP3) is a member of the mitochondrial carrier family expressed preferentially in skeletal muscle and heart. It appears to be involved in metabolic handling of fatty acids in a way that minimizes excessive production of reactive ...
Villarroya i Gombau, Francesc, Villarroya i Terrade, Joan, Gonzalez, Frank J., Solanes Garcia, Gemma, Pedraza González, Neus, Rosell Mañé, Meritxell, Iglesias Coll, María del Rosario   +6 more
core   +1 more source

Comparative Transcriptome Analysis Reveals That Exendin-4 Improves Steatosis in HepG2 Cells by Modulating Signaling Pathways Related to Lipid Metabolism

Biomedicines, 2022
No therapy exists for non-alcoholic fatty liver disease (NAFLD). However, glucagon-like peptide receptor agonists (GLP-1RAs) showed a beneficial effect on NAFLD, although the underpinning mechanisms remain unclear due to their pleiotropic effects.
Khaoula Errafii, Olfa Khalifa, Neyla S. Al-Akl, Abdelilah Arredouani   +3 more
doaj   +1 more source