Results 51 to 60 of about 6,765,357 (233)

Phytanic Acid is a Retinoid X Receptor Ligand [PDF]

European Journal of Biochemistry, 1996
Metabolic defects in phytanic acid catabolism have been shown to be connected with a number of human diseases which can lead to lethal defects of the nervous system and other organs. These effects are probably a result of the very high accumulation of phytanic acid in tissues throughout the body, due to defects in phytanic acid oxidation, the ...
P K, Lemotte, S, Keidel, C M, Apfel
openaire   +2 more sources

Retinoid X receptor gamma (RXRG) is an independent prognostic biomarker in ER-positive invasive breast cancer [PDF]

, 2019
© 2019, The Author(s), under exclusive licence to Cancer Research UK. Background: Retinoid X Receptor Gamma (RXRG) is a member of the nuclear receptor superfamily and plays a role in tumour suppression.
Toss, Michael, Nigel P. Mongan, Emad A. Rakha, Maariya Arshad, Mansour Alsaleem, Goh, Fang Qin, Alsaleem, Mansour, Ellis, Ian O, Michael S Toss, Green, Andrew R, Sara Al-Izzi, Ian O. Ellis, Mongan, Nigel P, Arshad, Maariya, Ibraheem M. Alshankyty, Sasagu Kurozumi, Joseph, Chitra, Mohammed A. Aleskandarany, Andrew R. Green, Chitra Joseph, Al-Izzi, Sara, Toss, Michael S, Alshankyty, Ibraheem M, Fang Qin Goh, Simak Ali, Kurozumi, Sasagu, Rakha, Emad A, Aleskandarany, Mohammed A, Ali, Simak   +28 more
core   +1 more source

The Role of the Enterohepatic Circulation of Bile Salts and Nuclear Hormone Receptors in the Regulation of Cholesterol Homeostasis: Bile Salts as Ligands for Nuclear Hormone Receptors

Canadian Journal of Gastroenterology, 2003
The coordinated effect of lipid activated nuclear hormone receptors; liver X receptor (LXR), bound by oxysterol ligands and farnesoid X receptor (FXR), bound by bile acid ligands, act as genetic transcription factors to cause feed-forward cholesterol ...
Richard N Redinger
doaj   +1 more source

Oncogenic potential of truncated RXRα during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling

Nature Communications, 2019
The truncated form of retinoid X receptor-alpha is found in cancer. Here, the authors show that this mutant receptor promotes colorectal tumorigenesis by activation of NF-κB in myeloid cells, leading to subsequent IL-6-induced STAT3 activation in ...
Xiaohong Ye, Hua Wu, Luoyan Sheng, Yi-xin Liu, Fang Ye, Mo Wang, Hu Zhou, Ying Su, Xiao-kun Zhang   +8 more
doaj   +1 more source

DNA Bending by Retinoid X Receptor-Containing Retinoid and Thyroid Hormone Receptor Complexes [PDF]

Molecular and Cellular Biology, 1993
Retinoid X receptors (RXR) have been identified as common subunits in the regulation of multiple hormonal signaling pathways. Using circular permutation and phasing analysis of specific response elements, we present evidence that RXR-retinoic acid receptor and RXR-thyroid hormone receptor heterodimer or RXR-RXR homodimer complexes induce directed DNA ...
X P, Lu, N L, Eberhardt, M, Pfahl
openaire   +2 more sources

The Biological Effects of Novel Synthetic Retinoids [PDF]

, 2010
Naturally occurring Retinoids are known to play a role in many developmental processes in the early embryo as well as being a potent tool for in vitro differentiation of stem cells. The exogenous application of these naturally occurring retinoids as well
BUDGE, JAMES,JOHN,ROWLAND
core  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

In vitro anti-angiogenic properties of LGD1069, a selective retinoid X-receptor agonist through down-regulating Runx2 expression on Human endothelial cells

BMC Cancer, 2011
Background LGD1069 (Targretin®) is a selective retinoid X receptor (RXR) ligand, which is used in patients for cutaneous T-cell lymphoma. Our published study reported that LGD1069 inhibited tumor-induced angiogenesis in non-small cell lung cancer.
Lu Hong, Liu Yu-Hui, Wang Wei, Fu Jianjiang, Luo Yongming   +4 more
doaj   +1 more source

AEG-1 Regulates Retinoid X Receptor and Inhibits Retinoid Signaling [PDF]

Cancer Research, 2014
Abstract Retinoid X receptor (RXR) regulates key cellular responses such as cell growth and development, and this regulation is frequently perturbed in various malignancies, including hepatocellular carcinoma (HCC). However, the molecule(s) that physically govern this deregulation are mostly unknown.
Jyoti, Srivastava, Chadia L, Robertson, Devaraja, Rajasekaran, Rachel, Gredler, Ayesha, Siddiq, Luni, Emdad, Nitai D, Mukhopadhyay, Shobha, Ghosh, Phillip B, Hylemon, Gregorio, Gil, Khalid, Shah, Deepak, Bhere, Mark A, Subler, Jolene J, Windle, Paul B, Fisher, Devanand, Sarkar   +15 more
openaire   +2 more sources

Identification of the First Retinoid X Receptor Homodimer Antagonist

, 2016
Identification of the First Retinoid X Receptor Homodimer ...
Steven K. White (182442), Stacie S. Canan Koch (3018885), Laura J. Dardashti (3018888), Jonathan J. Hebert (3018882), Alex M. Nadzan (2535841), Glenn E. Croston (3016215), Richard A. Heyman (3018876), Karen S. Flatten (3018879)   +7 more
core   +1 more source