Results 51 to 60 of about 57,833 (232)

Kidney regeneration: common themes from the embryo to the adult [PDF]

, 2013
The vertebrate kidney has an inherent ability to regenerate following acute damage. Successful regeneration of the injured kidney requires the rapid replacement of damaged tubular epithelial cells and reconstitution of normal tubular function ...
Cirio, Maria Cecilia, Davidson, Alan J., de Caestecker, Mark P., de Groh, Eric D., Hukriede, Neil A.   +4 more
core   +1 more source

Retinoid X receptors: X-ploring their (patho)physiological functions [PDF]

Cell Death & Differentiation, 2004
Retinoid X receptor (RXR) belongs to a family of ligand-activated transcription factors that regulate many aspects of metazoan life. A class of nuclear receptors requires RXR as heterodimerization partner for their function. This places RXR in the crossroad of multiple distinct biological pathways.
A, Szanto, V, Narkar, Q, Shen, I P, Uray, P J A, Davies, L, Nagy   +5 more
openaire   +2 more sources

Dual Functions of Dietary Rubber Seed Oil Supplementation: Enriching N‐3 Polyunsaturated Fatty Acids and Enhancing Antioxidant Capacity in Pekin Ducks

Animal Research and One Health, EarlyView.
Dietary RSO supplementation improved growth performance, simultaneously enriched n‐3 polyunsaturated fatty acids (n‐3 PUFA), and enhanced antioxidant capacity in Pekin ducks, which suggested that RSO has the potential to be a novel n‐3 PUFA source and an antioxidant for Pekin ducks to generate animal functional foods.
Lei Zhuang, Yongbao Wu, Zitao Zhao, Junting Cao, Yanhong Guo, Zhanyue Wu, Qimeng Wang, Peilong Yang, Sen Wu, Zhiguo Wen, Shuisheng Hou   +10 more
wiley   +1 more source

Vitamin D Receptor, Retinoid X Receptor, Ki-67, Survivin, and Ezrin Expression in Canine Osteosarcoma

Veterinary Medicine International, 2012
Canine osteosarcoma (OS) is an aggressive malignant bone tumor. Prognosis is primarily determined by clinical parameters. Vitamin D has been postulated as a novel therapeutic option for many malignancies.
John Davies, Heather Heeb, Rama Garimella, Kimberly Templeton, David Pinson, Ossama Tawfik   +5 more
doaj   +1 more source

In vitro anti-angiogenic properties of LGD1069, a selective retinoid X-receptor agonist through down-regulating Runx2 expression on Human endothelial cells

BMC Cancer, 2011
Background LGD1069 (Targretin®) is a selective retinoid X receptor (RXR) ligand, which is used in patients for cutaneous T-cell lymphoma. Our published study reported that LGD1069 inhibited tumor-induced angiogenesis in non-small cell lung cancer.
Lu Hong, Liu Yu-Hui, Wang Wei, Fu Jianjiang, Luo Yongming   +4 more
doaj   +1 more source

Evidence for gliadin antibodies as causative agents in schizophrenia. [PDF]

, 2010
Antibodies to gliadin, a component of gluten, have frequently been reported in schizophrenia. Highly immunogenic B cell epitopes along its length are homologous to numerous proteins relevant to schizophrenia, including members of the DISC1 interactome ...
Chris J. Carter
core   +2 more sources

Chromosomal Localization of the Human Retinoid X Receptors

Genomics, 1994
The recently described retinoid X receptors (RXRs) respond to the novel retinoid 9-cis-retinoic acid and also serve as heterodimeric partners for the vitamin D, thyroid hormone, and retinoic acid receptors (VDR, TR, and RAR, respectively). In this work, we report high-resolution localization of the human RXR genes within cytogenetic bands and also ...
A, Almasan, D J, Mangelsdorf, E S, Ong, G M, Wahl, R M, Evans   +4 more
openaire   +2 more sources

The Promiscuity of Allosteric Regulation of Nuclear Receptors by Retinoid X Receptor [PDF]

The Journal of Physical Chemistry B, 2016
The promiscuous protein retinoid X receptor (RXR) displays essential allosteric regulation of several members in the nuclear hormone receptor superfamily via heterodimerization and (anti)cooperative binding of cognate ligands. Here, the structural basis of the positive allostery of RXR and constitutive androstane receptor (CAR) is revealed. In contrast,
Alexander K, Clark, J Heath, Wilder, Aaron W, Grayson, Quentin R, Johnson, Richard J, Lindsay, Ricky B, Nellas, Elias J, Fernandez, Tongye, Shen   +7 more
openaire   +2 more sources

Vitamins as potent cancer treatments through regulating the activity and expression of MMP‐2 and MMP‐9

Bulletin of the Korean Chemical Society, EarlyView.
Vitamins could regulate both MMP‐2 and MMP‐9 expression and activity through transcriptional and MAPK signaling pathway modulation. This study highlights the potential of vitamins as low‐toxicity therapeutic or adjunct agents for targeting MMP‐mediated cancer progression. Abstract Matrix metalloproteinases (MMP‐2 and MMP‐9) are key regulators of cancer
Yen Thi Nguyen, Eungchan Kim, Ha Vy Thi Vo, Song Ja Kim, Namdoo Kim, Hyuck Jin Lee   +5 more
wiley   +1 more source

Genetic variants in the retinoid X receptor gene contribute to osteoarthritis susceptibility [PDF]

Archives of Biological Sciences
Osteoarthritis (OA) is a progressive disease of the joints that causes a gradual loss of function, resulting in limited mobility. Chronic inflammation is the main molecular process that triggers and propagates this disease. The retinoid X receptor (RXR),
Štefik Debora, Vranić Vladimir, Ivković Nemanja, Božić-Nedeljković Biljana, Šupić Gordana   +4 more
doaj   +1 more source