Results 71 to 80 of about 6,765,357 (233)

Comprehensive study of nuclear receptor DNA binding provides a revised framework for understanding receptor specificity

Nature Communications, 2019
The type II nuclear receptors (NRs) and the retinoid X receptor (RXR) form heterodimeric transcription factors to regulate development, metabolism, and inflammation.
Ashley Penvose, Jessica L. Keenan, David Bray, Vijendra Ramlall, Trevor Siggers   +4 more
doaj   +1 more source

Short photoperiod-induced decrease of histamine H3 receptors facilitates activation of hypothalamic neurons in the Siberian Hamster [PDF]

, 2009
Nonhibernating seasonal mammals have adapted to temporal changes in food availability through behavioral and physiological mechanisms to store food and energy during times of predictable plenty and conserve energy during predicted shortage.
Bartness, Timothy J., Barrett, Perry, van den Top, Marco, Spanswick, David C., Wilson, D., Mercer, Julian G., Morgan, Peter J., Song, C. K.   +7 more
core   +1 more source

A retinoid X receptor partial agonist attenuates pulmonary emphysema and airway inflammation

Respiratory Research, 2019
Background Retinoid X receptors (RXRs) are members of the nuclear receptor (NR) superfamily that mediate signalling by 9-cis retinoic acid, a vitamin A derivative.
Daisuke Morichika, Nobuaki Miyahara, Utako Fujii, Akihiko Taniguchi, Naohiro Oda, Satoru Senoo, Mikio Kataoka, Mitsune Tanimoto, Hiroki Kakuta, Katsuyuki Kiura, Yoshinobu Maeda, Arihiko Kanehiro   +11 more
doaj   +1 more source

Quantitative Analysis of Immune-Reactive Cells among Leukocytes Is Useful for the Diagnosis of Drug Eruptions Caused by Bexarotene

Case Reports in Oncology, 2022
Bexarotene is a third-generation retinoid X receptor-selective retinoid that has been approved for use in the treatment of cutaneous T-cell lymphomas (CTCLs). Since the objective response rate of bexarotene is relatively high, with no racial differences,
Hiromu Chiba, Yumi Kambayashi, Kentaro Ohuchi, Ryo Amagai, Erika Tamabuchi, Akira Hashimoto, Taku Fujimura   +6 more
doaj   +1 more source

Chromosomal Localization of the Human Retinoid X Receptors

Genomics, 1994
The recently described retinoid X receptors (RXRs) respond to the novel retinoid 9-cis-retinoic acid and also serve as heterodimeric partners for the vitamin D, thyroid hormone, and retinoic acid receptors (VDR, TR, and RAR, respectively). In this work, we report high-resolution localization of the human RXR genes within cytogenetic bands and also ...
A, Almasan, D J, Mangelsdorf, E S, Ong, G M, Wahl, R M, Evans   +4 more
openaire   +2 more sources

Endogenous retinoid X receptor ligands in mouse hematopoietic cells

, 2017
The long-chain fatty acid C24:5 is likely an endogenous ligand of the retinoid X receptor α in mouse hematopoietic cells.
Gregory R. Bowman, Gayla Hadwiger, John S. Welch, Mercedes Ricote, Orsola di Martino, Thomas E. Frederick, María P. Menéndez-Gutiérrez, Haixia Niu, Hideji Fujiwara   +8 more
core   +1 more source

Retinoid X Receptor α Regulates DHA-Dependent Spinogenesis and Functional Synapse Formation In Vivo

Cell Reports, 2020
Summary: Coordinated intracellular and extracellular signaling is critical to synapse development and functional neural circuit wiring. Here, we report that unesterified docosahexaenoic acid (DHA) regulates functional synapse formation in vivo via ...
Huateng Cao, Min-Yin Li, Guangying Li, Shu-Jing Li, Bincheng Wen, Yuan Lu, Xiang Yu   +6 more
doaj   +1 more source

Adaptive evolution of the Retinoid X receptor in vertebrates

Genomics, 2012
Retinoid X receptors (RXR) are transcription factors with important roles in development, reproduction, homeostasis, and cell differentiation. Different types of vertebrate RXRs (α (RXRA), ß (RXRB) and γ (RXRG)) have arisen from multiple duplication events.
Philip, Siby, Castro, L. Filipe C., da Fonseca, Rute R., Reis-Henriques, Maria A., Vasconcelos, Vítor, Santos, Miguel M., Antunes, Agostinho   +6 more
openaire   +2 more sources

The Promiscuity of Allosteric Regulation of Nuclear Receptors by Retinoid X Receptor [PDF]

The Journal of Physical Chemistry B, 2016
The promiscuous protein retinoid X receptor (RXR) displays essential allosteric regulation of several members in the nuclear hormone receptor superfamily via heterodimerization and (anti)cooperative binding of cognate ligands. Here, the structural basis of the positive allostery of RXR and constitutive androstane receptor (CAR) is revealed. In contrast,
Alexander K, Clark, J Heath, Wilder, Aaron W, Grayson, Quentin R, Johnson, Richard J, Lindsay, Ricky B, Nellas, Elias J, Fernandez, Tongye, Shen   +7 more
openaire   +2 more sources

The Nuclear Receptor Testicular Receptor 4 Orchestrates Cytoskeletal Organization in a G Protein Subunit Alpha 12/Rho‐Associated Protein Kinase–Dependent Manner to Promote Myofibroblast Differentiation and Tissue Fibrosis in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Members of the superfamily of nuclear receptors have been implicated in inflammatory processes and pathologic tissue remodeling and have emerged as attractive targets for pharmaceutical intervention. However, the role of testicular receptor 4 (TR4; or Nr2c2) in fibroblast activation and rheumatologic diseases has not yet been investigated ...
Yun Zhang, Lichong Shen, Junhui Zheng, Gisela Baur, Dilidaer Yasen, Honglin Zhu, Yi‐Nan Li, Xianyi Meng, Thuong Trinh‐Minh, Tim Filla, Debomita Chakraborty, Andrea‐Hermina Györfi, Christina Bergmann, Adam Reich, Alexander Kreuter, Georg Schett, Jörg H. W. Distler   +16 more
wiley   +1 more source