Results 81 to 90 of about 6,765,357 (233)

Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα

Nature Communications, 2017
The transcription factor retinoid X receptor-alpha (RXRα) can also form homotetramers. Here the authors show that the anti-cancer agent K-80003 selectively inhibits the nongenomic action of N-terminally-cleaved RXRα in tumour cells by stabilizing its ...
Liqun Chen, Alexander E. Aleshin, Gulimiran Alitongbieke, Yuqi Zhou, Xindao Zhang, Xiaohong Ye, Mengjie Hu, Gaoang Ren, Ziwen Chen, Yue Ma, Duo Zhang, Shuai Liu, Weiwei Gao, Lijun Cai, Lingjuan Wu, Zhiping Zeng, Fuquan Jiang, Jie Liu, Hu Zhou, Gregory Cadwell, Robert C. Liddington, Ying Su, Xiao-kun Zhang   +22 more
doaj   +1 more source

Retinoid X receptors: X-ploring their (patho)physiological functions [PDF]

Cell Death & Differentiation, 2004
Retinoid X receptor (RXR) belongs to a family of ligand-activated transcription factors that regulate many aspects of metazoan life. A class of nuclear receptors requires RXR as heterodimerization partner for their function. This places RXR in the crossroad of multiple distinct biological pathways.
A, Szanto, V, Narkar, Q, Shen, I P, Uray, P J A, Davies, L, Nagy   +5 more
openaire   +2 more sources

Retinoic acid modulates retinoid X receptor α and retinoic acid receptor α levels of cultured brown adipocytes [PDF]

, 1997
A novel potential regulatory pathway of brown adipose tissue (BAT) thermogenesis was recently recognized after identifying retinoic acid (RA) as a transcriptional activator of the uncoupling protein (UCP) gene.
Picó, Catalina, Vázquez, Francisca, Ribot, Joan, Bonet, M.Luisa, Serra, Francisca, Puigserver, Pere, Palou, Andreu   +6 more
core   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Roles of distinct nuclear receptors in diabetic cardiomyopathy

Frontiers in Pharmacology
Diabetes mellitus induces a pathophysiological disorder known as diabetic cardiomyopathy and may eventually cause heart failure. Diabetic cardiomyopathy is manifested with systolic and diastolic contractile dysfunction along with alterations in unique ...
Yangyang Zheng, Yongji Xu, Li Ji, Wenqing San, Danning Shen, Qianyou Zhou, Guoliang Meng, Jiahai Shi, Yun Chen   +8 more
doaj   +1 more source

Determinants of Retinoid X Receptor Transcriptional Antagonism

, 2016
The synthesis and bioactivity of the retinoid X receptor (RXR) antagonist 4-[(3‘-n-butyl-5‘,6‘,7‘,8‘-tetrahydro-5‘,5‘,8‘,8‘-tetramethyl-2‘-naphthalenyl)(cyclopropylidene)methyl]benzoic acid and several heteroatom-substituted analogues are described ...
Xiao-kun Zhang (325330), Claudio N. Cavasotto (187746), Robert C. Liddington (35197), Siva K. Kolluri (2709418), Valerie J. Peterson (2709424), Marcia I. Dawson (411957), Mark Leid (9124), Gang Liu (81776), Peter D. Hobbs (2417404), Sharon Y. James (2709421), Ananyo A. Bhattacharya (2709427), Ruben Abagyan (220938)   +11 more
core   +1 more source

Vitamin A and retinoid signaling: genomic and nongenomic effects

Journal of Lipid Research, 2013
Vitamin A or retinol is arguably the most multifunctional vitamin in the human body, as it is essential from embryogenesis to adulthood. The pleiotropic effects of vitamin A are exerted mainly by one active metabolite, all-trans retinoic acid (atRA ...
Ziad Al Tanoury, Aleksandr Piskunov, Cécile Rochette-Egly   +2 more
doaj   +1 more source

Loss of retinoid X receptor gamma subunit impairs group 1 mGluR mediated electrophysiological responses and group 1 mGluR dependent behaviors

Scientific Reports, 2021
Retinoid X receptors are members of the nuclear receptor family that regulate gene expression in response to retinoic acid and related ligands. Group 1 metabotropic glutamate receptors are G-protein coupled transmembrane receptors that activate ...
Chirag Upreti, Caitlin M. Woodruff, Xiao-Lei Zhang, Michael J. Yim, Zhen-yu Zhou, Andrew M. Pagano, Dina S. Rehanian, Deqi Yin, Eric R. Kandel, Patric K. Stanton, Russell E. Nicholls   +10 more
doaj   +1 more source

Retinoid X Receptor-Antagonistic Diazepinylbenzoic Acids.

Chemical and Pharmaceutical Bulletin, 1999
Several dibenzodiazepine derivatives were identified as novel retinoid X receptor (RXR) antagonists on the basis of inhibitory activity on retinoid-induced cell differentiation of human promyelocytic leukemia cells HL-60 and transactivation assay using retinoic acid receptors (RARs) and RXRs in COS-1 cells.
EBISAWA, Masayuki, UMEMIYA, Hiroki, OHTA, Kiminori, FUKASAWA, Hiroshi, KAWACHI, Emiko, CHRISTOFFEL, Ghislaine, GRONEMEYER, Hinrich, TSUJI, Motonori, HASHIMOTO, Yuichi, SHUDO, Koichi, KAGECHIKA, Hiroyuki   +10 more
openaire   +3 more sources

Separation of Retinoid X Receptor Homo- and Heterodimerization Functions [PDF]

Molecular and Cellular Biology, 2003
As a promiscuous dimerization partner the retinoid X receptor (RXR) can contribute to signaling by multiple nuclear receptors. However, the impact of RXR cosignaling and the possible existence of an RXR homodimer signaling pathway are largely unexplored.
Vivat-Hannah, Valerie, Bourguet, William, Gottardis, Marco, Gronemeyer, Hinrich   +3 more
openaire   +2 more sources