Results 101 to 110 of about 6,765,357 (233)

Farnesoid X receptor prevents hyperuricemia via activating ATP‐binding cassette subfamily G member 2

Rheumatology &Autoimmunity, EarlyView.
Farnesoid X receptor (FXR) activation reduces serum uric acid levels by upregulating the intestinal urate transporter ATP‐binding cassette subfamily G member 2 (ABCG2). These findings uncover a novel metabolic pathway for urate excretion and suggest that FXR agonists (e.g., obeticholic acid), represent a promising therapeutic strategy for the treatment
Rui Li, Guo Tang, Ye Yu, Guang‐Liang Chen, Liangjing Lu, Juan Wang   +5 more
wiley   +1 more source

Alternative retinoid X receptor (RXR) ligands

Molecular and Cellular Endocrinology, 2019
Retinoid X receptors (RXRs) control a wide variety of functions by virtue of their dimerization with other nuclear hormone receptors (NRs), contributing thereby to activities of different signaling pathways. We review known RXR ligands as transcriptional modulators of specific RXR-dimers and the associated biological processes.
Krężel, Wojciech, Rühl, Ralph, de Lera, Angel R.   +2 more
openaire   +3 more sources

Novel Retinoid X Receptor Antagonists:  Specific Inhibition of Retinoid Synergism in RXR−RAR Heterodimer Actions

, 2016
Several 2-(arylamino)pyrimidine-5-carboxylic acids were designed as novel retinoid X receptor (RXR) antagonists. Compound 6a or 6b alone did not exhibit differentiation-inducing activity toward HL-60 cells and did not affect the activity of a retinoic ...
Hiroshi Fukasawa (459067), Bitoku Takahashi (2689486), Yuichi Hashimoto (1665289), Hiroyuki Kagechika (838715), Emiko Kawachi (2132773), Kiminori Ohta (2246503)   +5 more
core   +1 more source

IGF-I receptor phosphorylation is impaired in cathepsin X-deficient prostate cancer cells [PDF]

, 2012
The cysteine-type peptidase cathepsin X is highly upregulated in several cancers and presumably promotes tumor invasion through bypassing cellular senescence. Here, we present first evidence that the underlying mechanism may involve the regulation of the
Kraus, Steffen, Bunsen, Thea, Fruth, Maximilian, Nägler, Dorit K.   +3 more
core   +1 more source

Integrative Bioinformatics, Experimental Validation, and Interpretable Machine Learning Reveal Oxyresveratrol‐Mediated Protection Against Cadmium‐Induced Lung Adenocarcinoma‐Related Transcriptional Dysregulation

Environmental Toxicology, EarlyView.
ABSTRACT Cadmium (Cd) is a toxic heavy metal strongly implicated in lung adenocarcinoma (LUAD) through mechanisms involving oxidative stress, epigenetic dysregulation, and chronic inflammation. This study aimed to identify Cd‐responsive genes associated with LUAD and to evaluate the protective effects of oxyresveratrol (O‐RES) against Cd‐induced ...
Murat Isıyel, Hamid Ceylan, Yeliz Demir
wiley   +1 more source

Retinoid X receptor activation is essential for docosahexaenoic acid protection of retina photoreceptors

Journal of Lipid Research, 2013
We have established that docosahexaenoic acid (DHA), the major polyunsaturated fatty acid in the retina, promotes survival of rat retina photoreceptors during early development in vitro and upon oxidative stress by activating the ERK/MAPK signaling ...
Olga L. German, Sandra Monaco, Daniela L. Agnolazza, Nora P. Rotstein, Luis E. Politi   +4 more
doaj   +1 more source

Distinct functional modes of SUMOylation for retinoid X receptor alpha [PDF]

, 2015
The present study investigated human retinoid X receptor alpha (hRXRa) as a substrate for modification with small ubiquitin like modifier (SUMO) and how members of the protein inhibitor of activated STAT (PIAS) family may impact upon this process.
Thompson, Paul, Jena, Sarita, Lee, WP, Jurutka, Peter W., Jena, S, Rodriguez, EP, Jurutka, PW, Lee, Wai-Ping, Rodriguez, Patricia, Thompson, PD, O'Donovan, SP, Wagner, Carl, O'Donovan, Sinead P., Wagner, C   +13 more
core   +1 more source

Decreased Production of Tissue Plasminogen Activator in Endothelial Cells From Nasal Polyps

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Introduction Previous studies have demonstrated that chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by excessive fibrin deposition which is related to impaired production of tissue plasminogen activator(t‐PA) by epithelial cells.
Qian‐Qian Zhang, Chen Zhang, Jia‐Ni Chen, Fu‐Ying Cheng, Yi‐Zhang Wang, Shi‐Rui Xue, Huan Wang, De‐Hui Wang, Xi‐Cai Sun, Li Hu   +9 more
wiley   +1 more source

Efficacy, Safety, and Maintenance Use of Topical Bexarotene in Early‐Stage Mycosis Fungoides: A Single‐Center Retrospective Real‐World Study

The Journal of Dermatology, EarlyView.
ABSTRACT Topical bexarotene 1% gel is an approved skin‐directed treatment for refractory or persistent stage IA‐IB cutaneous T‐cell lymphoma, but real‐world evidence in mycosis fungoides (MF), particularly regarding maintenance use after complete response, remains limited.
Fatich Memet, Dilek Bayramgürler, Abdullah Demirbaş, Evren Odyakmaz Demirsoy, Aysun Şikar Aktürk, Nilgün Sayman, Rebiay Kıran   +6 more
wiley   +1 more source

Amphibian‐Derived Peptide OA‐AL14 Alleviates UVB‐Induced Skin Photoaging via Autophagy Activation Mediated by the AMPK/mTOR Pathway

Integrative Zoology, EarlyView.
The schematic diagram illustrates that the amphibian‐derived peptide OA‐AL14 protects against UVB‐induced skin photoaging through a dual mechanism: activating the Nrf2 pathway to counteract oxidative stress and modulating the AMPK/mTOR axis to induce protective autophagy. ABSTRACT Skin photoaging, primarily driven by ultraviolet B (UVB) radiation, is a
Ying Peng, Yutong Wu, Zhe Fu, Zijian Kang, Qiuye Jia, Wenbi Zhao, Ziyi Wang, Yuexi Liu, Ruijie Zhang, Yuansheng Li, Zeqiong Ru, Wenrou Su, Naixin Liu, Yilin Li, Saige Yin, Ying Wang, Xinwang Yang   +16 more
wiley   +1 more source