Results 121 to 130 of about 6,765,357 (233)

Hydrogen/Deuterium Exchange Reveals Distinct Agonist/Partial Agonist Receptor Dynamics within Vitamin D Receptor/Retinoid X Receptor Heterodimer [PDF]

, 2010
SummaryRegulation of nuclear receptor (NR) activity is driven by alterations in the conformational dynamics of the receptor upon ligand binding. Previously, we demonstrated that hydrogen/deuterium exchange (HDX) can be applied to determine novel ...
Keith R. Stayrook, Dodge, Jeffery A., Griffin, Patrick R., Chalmers, Michael J., Garcia-Ordonez, Ruben D., Bruce D. Pascal, Michael J. Chalmers, Jeffery A. Dodge, Burris, Thomas P., Jun Zhang, Patrick R. Griffin, Lorri L. Burris, Stayrook, Keith R., Ruben D. Garcia-Ordonez, Thomas P. Burris, Pascal, Bruce D., Zhang, Jun, Burris, Lorri L.   +17 more
core   +1 more source

Bakuchiol: From structural mimicry to systems‐level skin biology

International Journal of Cosmetic Science, EarlyView.
Convergent outcomes, divergent mechanisms: bakuchiol vs. retinol. Bakuchiol exhibits functional convergence with retinol in improving extracellular matrix integrity, epidermal differentiation and barrier function, while operating through distinct mechanisms.
Ratan K. Chaudhuri
wiley   +1 more source

Vitamin A is linked to the expression of the AI-CIII-AIV gene cluster in familial combined hyperlipidemia

Journal of Lipid Research, 1999
There is growing evidence of the capacity of vitamin A to regulate the expression of the genetic region that encodes apolipoproteins (apo) A-I, C-III, and A-IV.
Josep Ribalta, Josefa Girona, Joan C. Vallvé, Agnes E. La Ville, Mercedes Heras, Lluís Masana   +5 more
doaj   +1 more source

Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans [PDF]

, 2001
Chicken xenobiotic receptor, pregnane X receptor, and constitutive androstane receptor are orphan nuclear receptors that have recently been discovered to regulate drug- and steroid-mediated induction of hepatic cytochromes P450 (CYP).
Stockli, J., Handschin, C., Meyer, U. A., Hoffmann, K., Podvinec, M.   +4 more
core  

Enhancing scar appearance: Results from a cosmetic clinical study on dexpanthenol‐containing silicone gel and massage ball in adults and children

International Journal of Cosmetic Science, EarlyView.
This cosmetic clinical study demonstrates improvements in scar appearance associated with the use of a dexpanthenol‐containing silicone gel with an integrated massage ball in adults and children. Abstract Objective To evaluate changes in scar appearance and tolerability associated with 8 weeks of use of a test product comprising a topical dexpanthenol ...
Erwan Peltier, Raffaella de Salvo, Natascha Hennighausen, Katrin Unbereit   +3 more
wiley   +1 more source

Effects of PPARγ Ligands on Leukemia

PPAR Research, 2012
Peroxisome proliferator-activated receptors (PPARs) and retinoic acid receptors (RARs), members of the nuclear receptor superfamily, are transcription factors that regulate a variety of important cellular functions.
Yoko Tabe, Marina Konopleva, Michael Andreeff, Akimichi Ohsaka   +3 more
doaj   +1 more source

Lignan‐rich Norway spruce (Picea abies) resin extract exhibits anti‐inflammatory, skin‐regenerative and anti‐acne effects: In vitro, in silico, biocompatibility and exploratory clinical findings

International Journal of Cosmetic Science, EarlyView.
GA text A 30% Picea abies resin extract cream combined antimicrobial, anti‐inflammatory and early pro‐repair activities relevant to acne‐prone skin. The formulation showed strong activity against Cutibacterium acnes, reduced inflammatory cytokines and demonstrated promising tolerability and efficacy in an exploratory in‐use study. Abstract Objective To
Simone Parrotta, Kamilla Yamileva, Laura Punakallio, Maryam Ghanbarirad, Evgen Multia   +4 more
wiley   +1 more source

An investigation of Cytochrome P450 function in human cell Lines for potential use in a bioartificial liver device [PDF]

, 2010
Bioartificial Liver Devices (BAL) could provide hepatic function in patients with liver failure awaiting transplantation or liver regeneration. Certain BALs use human hepatoblastoma-derived HepG2 cells that can perform many hepatocyte specific ...
Thomas, A.
core  

Contribution of targeted conditional somatic mutagenesis to deciphering retinoid X receptor functions and to generating mouse models of human diseases.

, 2007
The last decade has witnessed an enormous rise in the interest for retinoid signalling and its cognate receptors, because of their central role in the coordination of development and homeostasis, through their ability to orchestrate the expression of ...
Metzger, Daniel, Chambon, Pierre
core   +1 more source

Scalp Dysesthesia: Emerging Pathophysiologic Insights and Therapeutic Implications

International Journal of Dermatology, EarlyView.
Scalp dysesthesia is a chronic condition diagnosed through exclusion. This scoping review synthesized data from 59 patients to identify recurrent clinical features, comorbidities, and management strategies that may support earlier diagnosis. Emerging patterns suggest that neuronal sensitization may underlie common symptoms.
Aditya K. Gupta, Jaspreet Kaur, Amanda Liddy, Paradi Mirmirani, Vincent Piguet   +4 more
wiley   +1 more source