Results 131 to 140 of about 6,765,357 (233)
, 2018 Bexarotene Modulates Retinoid-X-Receptor Expression and Is Protective Against Neurotoxic Endoplasmic Reticulum Stress Response and Apoptotic Pathway ...
N Chitranshi (13363776) +8 more
core
Darier disease—A review highlighting new insights from the Darier Disease International Task Force
Journal of the European Academy of Dermatology and Venereology, EarlyView.This review provides a global, clinically focused overview of DD, detailing cutaneous and extracutaneous manifestations, disease classification and severity scoring. It emphasizes early recognition, multidisciplinary management and practical guidance for dermatologists to apply evidence‐based care in diverse skin phototypes. Abstract Darier disease (DD)
Sofia Labbouz +49 more
wiley +1 more source
Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis
Journal of Periodontal Research, EarlyView.A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger +5 more
wiley +1 more source
Role of peroxisome proliferator-activated receptor gamma and retinoid X receptor heterodimer in hepatogastroenterological diseases [PDF]
The peroxisome proliferator-activated receptor gamma (PPARgamma) and its partner the retinoid X receptor (RXR) are two nuclear receptors that are expressed mainly in adipose tissue and which have a role in lipid metabolism and insulin sensitisation.
Nutten, Sophie +5 more
core +1 more source
Obesity Reviews, EarlyView.ABSTRACT Despite all efforts, obesity remains a major health concern worldwide, with continuously increasing rates, affecting approx. 14% of the total world population, being as high as 43% in some countries. As obesity is related to numerous comorbidities, including type 2 diabetes, cardiovascular diseases, and some types of cancer, the consequences ...
Farhad Vahid +22 more
wiley +1 more source
Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation
, 2019 The fatty acid sensing nuclear receptor families retinoid X receptors (RXRs) and peroxisome proliferator-activated receptors (PPARs) hold therapeutic potential in neurodegeneration.
Julius Pollinger (6369068) +10 more
core +2 more sources
Translating gut microbiome research into therapies for type 1 diabetes
Experimental Physiology, EarlyView.Abstract Type 1 diabetes (T1D) is characterised by the loss of functional pancreatic β‐cells, for which lifelong insulin therapy remains the standard of care. Given that the gut microbiome can influence host health and that shifts in gut microbial profiles have been observed in T1D, growing interest has emerged in the role of the gut microbiome in T1D,
Shanti P. Kok +2 more
wiley +1 more source
Computational and Systems Oncology, Volume 6, Issue 1, December 2026.Sex‐stratified analyses of the TCGA and CGGA cohorts have identified promoter‐proximal TACSTD2 CpG sites where methylation shows opposite survival associations in males and females, is independent of copy number, and correlates with TACSTD2 expression.
Tahreem Fatima
wiley +1 more source
Retinoid receptor-selective gene regulation.
, 2013 (a) Retinoid receptor-selective induction of genes with specific roles in retinoid signaling or epidermal barrier homeostasis in skin of mice treated topically with selective agonists for RARα, RARγ or RXR for 14 days.
Janine Gericke (406379) +7 more
core +1 more source
Acta Physiologica, Volume 242, Issue 10, October 2026.ABSTRACT Background Chronic kidney disease (CKD) is characterized by progressive tubulointerstitial inflammation and fibrosis, particularly affecting the proximal tubule. Both proximal tubular epithelial cells and interstitial fibroblasts contribute to CKD progression through cell‐cycle arrest and phenotypic transitions.
Marie‐Christin Schulz +8 more
wiley +1 more source