Results 141 to 150 of about 6,765,357 (233)

Retinoid x receptor modulation protects against ER stress response and rescues glaucoma phenotypes in adult mice

, 2019
Retinoid x receptor modulation protects against ER stress response and rescues glaucoma phenotypes in adult ...
N Chitranshi (13363776), Y Dheer (13424799), Y You (13285080), Veer Gupta (13072143), S Sharma (7065461), M Abbasi (9153683), M Mirzaei (9999812), V Gupta (7723049), K Pushpitha (13379085), SL Graham (14583932)   +9 more
core  

Expression of retinoid x receptor beta is induced in astrocytes during corpus callosum demyelination

, 2012
The experimental activation of retinoid receptors reduces pathological symptoms in animal models of multiple sclerosis. In order to assess the involvement of endogenous retinoid signaling during the process of demyelination we investigated retinoic acid ...
Clarner, Tim, Markus Kipp, Kipp, Markus, Stifried, Milena, Cordian Beyer, Mey, Jörg, Beyer, Cordian, René König, Milena Stillfried, Clarner, Tim Guido, König, René, Tim Clarner, Jörg Mey, Stillfried, Milena, Aperdannier, Philipp, Mey, Joerg, Koenig, Rene, Philipp Aperdannier   +17 more
core   +1 more source

Beyond Deterministic Fetal Programming: Intrauterine Exposures and the Multifactorial Origins of Adiposity

Obesity Reviews, Volume 27, Issue 10, October 2026.
ABSTRACT Excess adiposity is not a recently developed problem but has existed since at least the upper Paleolithic, allowing evolutionary selection pressures to adapt the physiology of the pregnant woman and the feto‐placental unit for maternal and fetal protection.
Gernot Desoye, Ursula Hiden, Evelyn Jantscher‐Krenn, Herbert Fluhr, Jonathan C. Wells, Sonja Entringer, Mireille N. M. van Poppel   +6 more
wiley   +1 more source

Solution Structures of PPARγ2/RXRα Complexes

PPAR Research, 2012
PPARγ is a key regulator of glucose homeostasis and insulin sensitization. PPARγ must heterodimerize with its dimeric partner, the retinoid X receptor (RXR), to bind DNA and associated coactivators such as p160 family members or PGC-1α to regulate gene ...
Judit Osz, Maxim V. Pethoukhov, Serena Sirigu, Dmitri I. Svergun, Dino Moras, Natacha Rochel   +5 more
doaj   +1 more source

SIRT1 in Neurodegenerative Diseases: Molecular Mechanisms, Disease Relevance, and Therapeutic Potential

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
SIRT1, an NAD+‐dependent deacetylase, supports cognitive resilience by coordinating neuroprotection, synaptic plasticity, autophagy–lysosomal proteostasis, and mitochondrial energy homeostasis. Reduced or dysregulated SIRT1 is associated with protein aggregation, neuroinflammation, mitochondrial dysfunction, synaptic loss, and cognitive decline in ...
Jiabin Duan, Jiaqi Liu, Qingsheng Meng, Jiahao Liu, Sitian Yang, Fang Zhou, Jing Cao   +6 more
wiley   +1 more source

A Novel SXXLF Motif in the FXR N‐Terminal Domain Mediates Coregulator and Interdomain Interactions

ChemBioChem, Volume 27, Issue 17, 14 September 2026.
Farnesoid X receptor (FXR)‐N‐terminal domain (NTD) regulates transcriptional activity through interdomain communication with the LBD and is also involved in co‐activator recruitment. The SENLF motif is the first defined functional element within the FXR‐NTD and mediates both NTD–LBD interaction and selective co‐activator engagements to drive NTD ...
Priscilla Villalona, Thilini Pulahinge, Tracy Yu, Jordan Wenning, Sabab Hasan Khan, Crawford Joseph Frisbie, Jill Magafas, Addison Barbe, C. Denise Okafor   +8 more
wiley   +1 more source

Retinoid X receptor alpha (RXRα) and peroxisome proliferator-activated receptor gamma (PPARγ) expression in breast cancer: an immunohistochemical study

, 2012
The role of retinoid X receptor alpha (RXRα) and peroxisome proliferator-activated receptor gamma (PPARγ) in breast cancer has been well studied in vitro. The aim of the study was to assess the presence of these molecules in human breast cancer specimens
Mayr, D, Gallwas, J., Vrekoussis, T, Lenhard, M, Rühl, I, Friese, K, Ditsch, N, Weissenbacher, T, Makrigiannakis, A, Jeschke, U   +9 more
core   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

Syntaxin‐3 Regulates Tight Junction Assembly in Human Retinal Pigment Epithelium

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT The retinal pigment epithelium (RPE) consists of polarized epithelial cells, serving as a support system for photoreceptor maintenance, where the polarity is contributed by the distribution of syntaxins (STX) within the cell. STX3, a known regulator of apical trafficking in epithelial cells, was previously understood to be absent in human RPE ...
Athira Ramesh, Suganya Sivagurunathan, Navya Valavath Baburajan, Subbulakshmi Chidambaram   +3 more
wiley   +1 more source

PRAME promotes invasion and metastasis of salivary adenoid cystic carcinoma by regulating RARα stability via the cullin2 ubiquitin‐proteasome system

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
PRAME promotes SACC invasion and metastasis by inducing EMT via Twist1 upregulation and by destabilizing RARα through Cullin2‑mediated ubiquitination, a mechanism that may limit ATRA efficacy. In vivo, PRAME enhances subcutaneous growth and lung metastasis, highlighting its oncogenic role in SACC.
Xudong Wang, Tingyao Ma, Yixin Jing, Tianyi Li, Xi Zhao, Guohan Zhao, Ran Gao, Lu Kong, Xiaohong Chen   +8 more
wiley   +1 more source