Results 141 to 150 of about 37,733 (224)

MS275 Inhibits Neuroblastoma Cell Growth by Mediating H3K27ac/PROX1 Axis In Silico and In Vitro

The FASEB Journal, Volume 39, Issue 13, 15 July 2025.
Our study demonstrates that MS275, a selective HDAC inhibitor, suppresses HDAC1/3 protein expression, leading to hyperacetylation of histone H3 at lysine 27 (H3K27ac) within the PROX1 promoter region (−608 to −508). This epigenetic modification upregulates PROX1 transcription, which subsequently modulates key cellular processes, including cell cycle ...
Chao Yuan, Chaoqun Li, Junwei Lu, Shengjie Liao, Runkun Wu, Duanzhuo Li, Mi Huang, Dacong Gong, Weibin Wu, Xin Yu, Shinuan Fei, Wenxia Si   +11 more
wiley   +1 more source

Metabolic Profiling Reveals Diagnostic Biomarkers for Distinguishing Myocarditis From Acute Myocardial Infarction. [PDF]

Cardiovasc Ther
Chen Y, Liu X, Hong C, Xu S, He L, Liu Z, Chen H, Lin Y.   +7 more
europepmc   +1 more source

MTA‐TST Axis‐Mediated Apoptosis Activation: A Multi‐Omics Insight Into High‐Protein Diet's Anti‐Adiposity Effect

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
High protein diet reduced visceral adipose tissue through MTA‐TST‐Bak/Casp‐3 axis, suggesting that MTA has the potential to be developed as a functional substance for obesity prevention and control. ABSTRACT To explore the mechanism of a high‐protein diet (named high protein and rich fat diet, HPRFD) with weight loss effect regulating visceral fat ...
Xinli Yang, Yueyue Wang, Zhe Shi, Aiting Wang, Jianglan Long, Dan Yan   +5 more
wiley   +1 more source

Polyoxyethylene and polypropylene emulsification enhances retinol palmitate efficacy in corneal wound healing. [PDF]

Sci Rep
Horiuchi H, Watanabe K, Iijima H, Obayashi Y.   +3 more
europepmc   +1 more source

Causal Relationship Between Various Vitamins and Different Diabetic Complications: A Mendelian Randomization Study

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
The potential causal relationships between six diabetic complications and four circulating vitamins in diabetics were explored through two‐sample Mendelian randomization analyses. ABSTRACT Epidemiological evidence regarding the association between vitamins and diabetic complications remains inconsistent.
Sijia Cai, Weitao Man, Wenqing Liu, Bowu Li, Zhongchen He, Guman Duan   +5 more
wiley   +1 more source

The immunomodulatory p43 secreted protein of Trichuris whipworm parasites is a lipid carrier that binds signalling lipids and precursors. [PDF]

Sci Rep
Kennedy MW, Bancroft AJ, Grencis RK.
europepmc   +1 more source

Purification, Structural Characterization, Antioxidant Activity, and In Vitro Digestibility of Peach Gum Polysaccharide Extracted Using an Enzymatic Method

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
Xylanase was employed for the extraction of peach gum polysaccharide, resulting in the production of a low molecular weight polysaccharide with a molecular weight of 1.3 × 106 Da. Low molecular weight polysaccharides exhibit elevated antioxidant activity. EPGP demonstrates superior emulsification properties compared to AG and MG.
Xiaohua Cheng, Shubo Chen, Yang Liu, Feng Yang, Jie Chen   +4 more
wiley   +1 more source

Randomized Controlled Clinical Trial of Pediatric Pneumococcus and Hepatitis A Vaccinations With or Without a High-Dose Oral Vitamin A Supplement. [PDF]

Biomolecules
Patel N, Surman SL, Jones BG, Penkert RR, Ringwald-Smith K, DeLuca K, Richardson J, Zheng Y, Tang L, Hurwitz JL.   +9 more
europepmc   +1 more source

Umbilical Cord‐Mesenchymal Stromal Cell‐Derived Extracellular Vesicles Target the Liver to Improve Neurovascular Health in Type 2 Diabetes With Non‐Alcoholic Fatty Liver Disease

Journal of Extracellular Vesicles, Volume 14, Issue 7, July 2025.
Therapeutic extracellular vesicles (EVs) predominantly accumulate in the diabetic liver, delivering miR‐31‐5p to suppress macrophage platelet‐derived growth factor B (PDGFB), thereby impeding non‐alcoholic fatty liver disease (NAFLD) progression and enhancing neurovascular health by promoting pericyte recovery and transthyretin (TTR)‐mediated ...
Minghao Du, Hao Yang, Jinyun Niu, Jing Huang, Lihong Wang, Junxiu Xi, Panpan Meng, Zhiyong Liu, Guaiguai Ma, Jiani Li, Xiaoyan Liu, Liang Guo, Mingjun Hu, Zhufang Tian, Bin Liu, Weiping Liu, Ashok K. Shetty, Shengxi Wu, Andrius Baskys, Qianfa Long   +19 more
wiley   +1 more source

Vitamin A concentration in bovine liver and milk does not only depend on characteristics of the farming system. [PDF]

NPJ Sci Food
Schulz K, Bachmann M, Raila J, Schmitt R, Staufenbiel R, Scholz H, Wensch-Dorendorf M, Ptok S, Weissenborn A, Pieper R.   +9 more
europepmc   +1 more source