Results 21 to 30 of about 37,733 (224)
Hepatology, EarlyView., 2022 Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog +12 more
wiley +1 more source
ACS Chemical Biology, 2010 Transthyretin (TTR) is a plasma hormone carrier protein associated with hereditary and senile forms of systemic amyloid disease, wherein slow tetramer disassembly is thought to be an obligatory step. Plasma transport of retinol is carried out exclusively by the retinol-binding protein (RBP), through complexation with transthyretin.
Hyung, Suk-Joon +2 more
openaire +3 more sources
Interactions with Retinol and Retinoids of Bovine Cellular Retinol‐Binding Protein [PDF]
European Journal of Biochemistry, 1995 The interactions with retinol and retinol analogs of bovine cellular retinol‐binding protein (CRBP) have been investigated, by means of fluorescence titrations, to obtain more information on the structural features of retinoids that may be required for their interaction with the binding protein.
MALPELI G +4 more
openaire +3 more sources
Retinol‐induced secretion of human retinol‐binding protein in yeast [PDF]
FEBS Letters, 1998 Retinol‐binding protein (RBP) functions as a transporter for retinol (vitamin A) in plasma in higher eukaryotes. We have successfully expressed human RBP in Saccharomyces cerevisiae, and its secretion was found to be induced by retinol also in this lower eukaryote. Reduced induction of secretion by retinol in a temperature‐sensitive sec18‐1 mutant that
Sjur Reppe +3 more
openaire +3 more sources
Protein aggregation and neurodegenerative disease: Structural outlook for the novel therapeutics
Proteins: Structure, Function, and Bioinformatics, EarlyView., 2023 Abstract Before the controversial approval of humanized monoclonal antibody lecanemab, which binds to the soluble amyloid‐β protofibrils, all the treatments available earlier, for Alzheimer's disease (AD) were symptomatic. The researchers are still struggling to find a breakthrough in AD therapeutic medicine, which is partially attributable to lack in ...
Sharif Arar +2 more
wiley +1 more source
Journal of International Medical Research, 2018 Objectives To analyse intake of vitamin A (VA) and retinol concentrations in maternal blood, breast milk (BM), and the umbilical cord (UC) of newborns, and to determine the associations among these variables.
Thalia Manfrin Martins Deminice +5 more
doaj +1 more source
Controlled Release of Retinol in Cationic Co-Polymeric Nanoparticles for Topical Application
Cosmetics, 2020 Retinol is a compound used in many skin care formulations to act against skin conditions like acne, wrinkles, psoriasis, and ichthyosis. While retinol is used as an active ingredient, its efficacy is limited by an extreme sensitivity to light and ...
Fabien Goudon +2 more
doaj +1 more source
Iron deficiency and anemia are associated with low retinol levels in children aged 1 to 5 years
Jornal de Pediatria, 2014 Objective: To analyze the occurrence of anemia and iron deficiency in children aged 1 to 5 years and the association of these events and retinol deficiency.
Bárbara C.A. Saraiva +4 more
doaj +5 more sources
Validation of the Use of Dried Blood Spot (DBS) Method to Assess Vitamin A Status [PDF]
Health Promotion Perspectives, 2012 Background: Vitamin A deficiency is an important dietary deficiency in the world. Thus, the ne-cessity of screening for deficient populations is obvious.
Elham Fallah, Seyed Hadi Peighambardoust
doaj +1 more source
Retinol and Retinol‐Binding Protein: Gut Integrity and Circulating Immunoglobulins [PDF]
The Journal of Infectious Diseases, 2000 Vitamin A (retinol) is required to maintain immunity and epithelial turnover and is a key micronutrient needed for combating infection. Vitamin A actions on the immune system are diverse and cannot be accounted for by a single effect or mechanism.
Aldo A. M. Lima +9 more
openaire +3 more sources