Results 121 to 130 of about 185,541 (306)

Retinol binding protein 4 – a novel association with early-onset preeclampsia [PDF]

Journal of Perinatal Medicine, 2010
Dysregulation of maternal circulating adipokines has been implicated in several "great obstetrical syndromes" including preeclampsia (PE), small-for-gestational age (SGA) neonate and fetal death (FD). It has been suggested that adipokines provide a molecular link between metabolic derangements and inflammatory response in complicated pregnancies ...
Edi, Vaisbuch, Roberto, Romero, Shali, Mazaki-Tovi, Offer, Erez, Sun Kwon, Kim, Tinnakorn, Chaiworapongsa, Francesca, Gotsch, Nandor Gabor, Than, Zhong, Dong, Percy, Pacora, Ronald, Lamont, Lami, Yeo, Sonia S, Hassan, Juan Pedro, Kusanovic   +13 more
openaire   +2 more sources

Nutritional status of young children with inherited blood disorders in western Kenya. [PDF]

, 2014
To determine the association between a range of inherited blood disorders and indicators of poor nutrition, we analyzed data from a population-based, cross-sectional survey of 882 children 6–35 months of age in western Kenya.
Ruth, LJ, Suchdev, PS, Sullivan, KM, Tsang, BL, Williams, TN   +4 more
core   +1 more source

Discovery of Bispecific Antagonists of Retinol Binding Protein 4 That Stabilize Transthyretin Tetramers: Scaffolding Hopping, Optimization, and Preclinical Pharmacological Evaluation as a Potential Therapy for Two Common Age-Related Comorbidities.

Journal of Medicinal Chemistry, 2020
Accumulation of cytotoxic lipofuscin bisretinoids may contribute to atrophic age-related macular degeneration (AMD) pathogenesis. Retinal bisretinoid synthesis depends on influx of serum all-trans-retinol (1) delivered via a tertiary retinol-binding ...
C. Cioffi, Parthasarathy Muthuraman, A. Raja, A. Váradi, B. Rácz, K. Petrukhin   +5 more
semanticscholar   +1 more source

Transthyretin levels in the vitreous correlate with change in visual acuity after vitrectomy [PDF]

, 2009
Background/aim: Little is known about biochemical markers related to change in visual acuity after vitrectomy. The potential use of transthyretin (TTR), a carrier of the retinol/retinol-binding protein, as a biochemical marker protein, was investigated ...
De Letter, Els, Delanghe, Joris, Delanghe, S, Derycke, Lara, Geers, I, Van Aken, Elisabeth, van Enschot, T, Veckeneer, M   +7 more
core   +3 more sources

Data correlations between gender, cytomegalovirus infection and T cells, NK cells, and soluble immune mediators in elderly humans

Data in Brief, 2016
We describe a cohort of 50 elderly subjects, age at least 70 years. We present gender-specific findings in T lymphocyte markers and soluble immune mediators.
Ahmad Al-Attar, Steven R. Presnell, Charlotte A. Peterson, D. Travis Thomas, Charles T. Lutz   +4 more
doaj   +1 more source

A Functional Binding Domain in the Rbpr2 Receptor Is Required for Vitamin A Transport, Ocular Retinoid Homeostasis, and Photoreceptor Cell Survival in Zebrafish

Cells, 2020
Dietary vitamin A/all-trans retinol/ROL plays a critical role in human vision. ROL circulates bound to the plasma retinol-binding protein (RBP4) as RBP4-ROL. In the eye, the STRA6 membrane receptor binds to circulatory RBP4 and internalizes ROL. STRA6 is,
Ashish K. Solanki, Altaf A. Kondkar, Joseph Fogerty, Yanhui Su, Seok-Hyung Kim, Joshua H. Lipschutz, Deepak Nihalani, Brian D. Perkins, Glenn P. Lobo   +8 more
doaj   +1 more source

Association of Serum Retinol-Binding Protein 4 Levels and the Risk of Incident Type 2 Diabetes in Subjects With Prediabetes

Diabetes Care, 2019
OBJECTIVE To explore the association of serum retinol-binding protein 4 (RBP4) levels and risk for the development of type 2 diabetes in individuals with prediabetes.
Jiahua Fan, Songping Yin, Diaozhu Lin, Yangqing Liu, N. Chen, Xinxiu Bai, Q. Ke, Jia Shen, Lili You, Xiu-hong Lin, Feng Li, F. He, Li Yan, Chao-gang Chen, M. Xia   +14 more
semanticscholar   +1 more source

Circulating Retinol-Binding Protein 4 Is Inversely Associated With Pancreatic β-Cell Function Across the Spectrum of Glycemia

Diabetes Care, 2020
OBJECTIVE The aim of this study was to examine the association of circulating retinol-binding protein 4 (RBP4) levels with β-cell function across the spectrum of glucose tolerance from normal to overt type 2 diabetes.
Rong Huang, Songping Yin, Y. Ye, N. Chen, S. Luo, M. Xia, Lina Zhao   +6 more
semanticscholar   +1 more source

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, EarlyView.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source

Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function [PDF]

, 2018
Visual function in vertebrates critically depends on the continuous regeneration of visual pigments in rod and cone photoreceptors. RPE65 is a well-established retinoid isomerase in the pigment epithelium that regenerates rhodopsin during the rod visual ...
Angueyra, Juan M, Badiee, Mohsen, Kefalov, Vladimir J, Kinoshita, Junzo, Kiser, Philip D, Kolesnikov, Alexander V, Li, Wei, Palczewski, Krzysztof, Peachey, Neal S, Sharma, Aditya, Tochtrop, Gregory P, Zhang, Jianye   +11 more
core   +1 more source