Interplay of retinol binding protein 4 with obesity and associated chronic alterations (Review). [PDF]
Mol Med Rep, 2022 Obesity is a multifactorial disease, defined as excessive fat deposition in adipose tissue. Adipose tissue is responsible for the production and secretion of numerous adipokines that induce metabolic disorders.
Flores-Cortez YA +5 more
europepmc +2 more sources
The relationship between NAFLD and retinol-binding protein 4 - an updated systematic review and meta-analysis. [PDF]
Lipids Health Dis, 2023 Purpose Retinol-binding protein 4 (RBP4) has been considered to be related to metabolic related diseases, such as hyperuricemia, obesity, and diabetes mellitus.
Hu R, Yang X, He X, Song G.
europepmc +2 more sources
Retinoid Homeostasis and Beyond: How Retinol Binding Protein 4 Contributes to Health and Disease. [PDF]
Nutrients, 2022 Retinol binding protein 4 (RBP4) is the specific transport protein of the lipophilic vitamin A, retinol, in blood. Circulating RBP4 originates from the liver.
Steinhoff JS, Lass A, Schupp M.
europepmc +2 more sources
Neutrophil Gelatinase-Associated Lipocalin and Retinol-Binding Protein-4 as Biomarkers for Diabetic Kidney Disease [PDF]
Kidney & Blood Pressure Research, 2020 Aims: This study was designed to evaluate the conflicting association between 2 tubular protein markers including neutrophil gelatinase-associated lipocalin (NGAL) and retinol-binding protein-4 (RBP-4) with albuminuria and glomerular filtration rate (GFR)
F. Abbasi +8 more
semanticscholar +2 more sources
World Journal of Diabetes, 2021 BACKGROUND Atherosclerosis is a major cause of mortality worldwide and is driven by multiple risk factors, including diabetes, which results in an increased atherosclerotic burden, but the precise mechanisms for the occurrence and development of diabetic
Wan Zhou, S. Ye, W. Wang
semanticscholar +2 more sources
Identification and Characterization of a Non-retinoid Ligand for Retinol-binding Protein 4 Which Lowers Serum Retinol-binding Protein 4 Levels in Vivo [PDF]
Journal of Biological Chemistry, 2009 Retinol-binding protein 4 (RBP4) transports retinol from the liver to extrahepatic tissues, and RBP4 lowering is reported to improve insulin sensitivity in mice. We have identified A1120, a high affinity (K(i) = 8.3 nm) non-retinoid ligand for RBP4, which disrupts the interaction between RBP4 and its binding partner transthyretin.
Alykhan Motani +16 more
openalex +4 more sources
Retinol binding protein 4 and type 2 diabetes: from insulin resistance to pancreatic β-cell function. [PDF]
EndocrineRetinol binding protein 4 (RBP4) is an adipokine that has been explored as a key biomarker of type 2 diabetes mellitus (T2DM) in recent years. Researchers have conducted a series of experiments to understand the interplay between RBP4 and T2DM, including
Fan J, Hu J.
europepmc +2 more sources
The correlation of retinol-binding protein-4 and lipoprotein combine index with the prevalence and diagnosis of acute coronary syndrome [PDF]
Heart and Vessels, 2020 Retinol-binding protein-4 (RBP-4) along with the lipid profile plays crucial roles in Acute coronary syndrome (ACS). The study aimed to investigate the correlation of RBP-4, lipoprotein combine index (LCI), and RBP-4 + LCI with ACS.
Y. Si +5 more
semanticscholar +2 more sources
Retinol-binding protein 4 in cardiovascular diseases: mechanisms and therapeutic perspectives [PDF]
Frontiers in Cardiovascular MedicineCardiovascular diseases (CVDs) continue to be the leading cause of mortality worldwide, highlighting the need for enhanced diagnostic tools to enable early intervention.
Jiefang Chen +4 more
doaj +2 more sources
Retinol, Retinoic Acid, and Retinol-Binding Protein 4 are Differentially Associated with Cardiovascular Disease, Type 2 Diabetes, and Obesity: An Overview of Human Studies. [PDF]
Advances in Nutrition, 2019 Vitamin A is a fat-soluble essential nutrient obtained from plant- and animal-based sources that has roles in growth, vision, and metabolism. Vitamin A circulates mainly as retinol bound to retinol-binding protein 4 (RBP4), and is delivered to tissues ...
T. Olsen, R. Blomhoff
semanticscholar +2 more sources